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The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of the lectin pathway of complement in humans, but its role in systemic autoimmune disease has not been conclusively determined. Here, we combined biochemical and genetic approaches to assess the contribution o
Introduction Mild traumatic brain injury is common in children and it can be challenging to accurately identify those in need of urgent medical intervention. The Scandinavian guidelines for management of minor and moderate head trauma in children, the Scandinavian Neurotrauma Committee guideline 2016 (SNC16), were developed to aid in risk stratification and decision-making in Scandinavian emergenc
BACKGROUND: In the European Union alone, more than 100 million people present to the emergency department (ED) each year, and this has increased steadily year-on-year by 2-3%. Better patient management decisions have the potential to reduce ED crowding, the number of diagnostic tests, the use of inpatient beds, and healthcare costs.METHODS: We have established the Skåne Emergency Medicine (SEM) co
INTRODUCTION: There are currently no colorectal cancer (CRC) screening recommendations specifically outlined for people with HIV (PWH). Screening measures used for people without HIV (PWoH) have been previously discussed as sufficient for use among PWH, despite observations of higher CRC prevalence and CRC reportedly appearing at earlier ages among PWH in comparison to PWoH. Machine learning (ML)
PURPOSE: The primary aim of this study is to analyse the patient-reported outcomes after ACLR complicated by septic arthritis. The secondary aim is to examine the 5-year risk of revision surgery after primary ACLR complicated by septic arthritis. The hypothesis was that patients with septic arthritis after ACLR are more likely to have lower PROMs scores and an increased risk of revision, compared
Today, "the digital library" is the common way of describing a managed collection of information, with associated services, stored in digital formats and accessible over a network. Digital libraries have mainly been developed at research libraries, but during the last few years public libraries have started to offer similar services. The aim of this Master's thesis is to study how t
The myth of the user - a study of the user discourse and its visionaries This study is a discourse analysis of the visions that implicitly are expressed in different texts about user-centered library theory. Several other studies have analyzed the discourse and conceptualization of how the user is expressed in the library debate. Therefore we have chosen to analyze the visions that are expressed
This thesis has two aims: The main purpose is to describe and illustrate how a large Ltd. company can use voluntary redundancy as a tool for restructuring. The additional purpose is to challenge the concept of voluntary redundancy trough outlining alternative ways of reaching the intended achievements of the voluntary redundancy programme. The theoretical framework that has been used primarily con
The Community law has supremacy to national law. Therefore, the fundamental rights conferred by the EC Treaty usually take precedence over the national legislation of Member States. That is to say, if they cannot be justified on some of the justification grounds established by the settled case-law of the ECJ. In spite of the supremacy of the EC law, Member States have maintained their authority in
Brottsutvecklingen i Sverige har under de senaste åren föranlett utökade befogenheter i den brottsbekämpande verksamheten. Diskussionerna kring utökningar av tillämpningsområdet för preventiva tvångsmedel har varit synnerligen aktuella, och det har skett många lagändringar i vår närtid. En av de senaste lagändringarna är införandet av hemlig rumsavlyssning som ett preventivt tvångsmedel. Hemlig ru
