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Background and objective: General anaesthesia impairs respiratory function. The present studies were performed to compare arterial concentration of sevoflurane, oxygen and carbon dioxide in normal and overweight patients ventilated with increased tidal volume (VT), or normal tidal volume with and without PEEP. Methods: Prospective, randomised, clinical studies. ASA І and II abdominal surgery patie
FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. FLT3 mutations cause constitutive activation of intrinsic tyrosin
Human endogenous retroviruses (HERVs) are remains of ancient retroviral infections of the germ line and constitute as much as 3 % of the human genome. HERVs are genetic elements that potentially may provide important biological functions by several different mechanisms. The ability to transpose long after the initial insertion into the germ line may provide a potent source of insertional mutagenes
A shipyards' right of retention is somewhat of a phenomenon, enabling the shipyard to retain property and secure credit accordingly. The right of retention has a character that is similar to a so-called legal lien. The current regulation in the MC governing retention has its roots in the 1967 Convention on Maritime Liens and Mortgages. There are several kinds of retention rights. The one prima
1997 beslutade Sveriges riksdag att lägga den så kallade ”Nollvisionen” till grund för trafiksäkerhetsarbetet i landet. Nollvisionen innebär att det skall bli säkrare för alla inblandade att vistas ute i trafiken. Man har satt upp ett mål att antalet trafikolyckor som resulterar i dödsfall och skador för livet skall minimeras. Denna målsättning vill man uppnå genom att bland annat: förbättra vägar
Religionsfrihet är en grundläggande mänsklig rättighet. Artikel 9 i Europakonventionen reglerar religionsfriheten och dess begränsningar. Konventionen är inkorporerad i svensk lagstiftning och ska således tillämpas i Sverige. Med anledning av det så kallade handskakningsmålet ställs religionsfriheten i förhållande till arbetet mot ett könsjämlikt arbetsliv. Frågan väcks och diskuteras huruvida rel
Organiserad brottslighet är ett väldigt aktuellt ämne som diskuteras såväl i Sverige som internationellt. Diskussionerna rör bl.a. den organiserade brottslighetens struktur, hur utbredd den är, dess medlemmar, dess kriminalitet och det hot den innebär mot samhället. Många har starka åsikter gällande organiserad brottslighet och det talas om att krafttag mot den behöver tas och olika åtgärdsprogram
The purpose of this study was to examine how care managers handle the expectations and damands of their profession. More specifically its aim was to find out how they handle the demands from the elder and his och hers relatives. The aim was also to study how the care managers related to laws and municipal guidelines and how the organizational factors affected their work. I chose to do six semi con
National parks have been a common way of protecting biodiversity, and the model has been spreading around the world since the first national park of the world, Yellowstone, was established in the U.S. more than 130 years ago. However, the concept of national parks has also been criticized, for example as representing a North-perception of the environment that is imposed on the South. The purpose o
During the last decades considerably more of medical students’ clinical training has shifted into general practice. The aim of this thesis was to study medical students’ learning experiences in general practice, work-based assessment, and the perspectives of GP supervisors and patients. Results Senior students’ learning in a portfolio pilot was mainly on patient-centred communication, clinical re
Popular Abstract in English The main aim of this thesis was to contribute to the knowledge about mechanisms involved in the development of type 1 diabetes (T1D) and other autoimmune diseases in children. Immune markers in relation to genetic propensity in children with autoimmune disease, mainly T1D and a small group of juvenile idiopathic arthritis (JIA) and thyroiditis (THYR), as well as healthyThe main aim of this thesis was to contribute to the knowledge about mechanisms involved in the development of type 1 diabetes (T1D) and other autoimmune diseases in children. Immune markers in relation to genetic propensity in children with autoimmune disease, mainly T1D and a small group of juvenile idiopathic arthritis (JIA) and thyroiditis (THYR), as well as healthy controls have been studied.
