71 consecutive posterolateral lumbar fusions without decompression or internal fixation were evaluated with a mean follow-up time of 3.5 (2-7) years. The diagnoses were spondylolysis-olisthesis in 43 cases, degenerative disc disease and/or facet joint arthrosis in 16 cases and pain post laminectomy/ decompression in 12 cases. 54/70 patients had a solid fusion. In the group with spondylolysis-olist

The goal of the study was to get a better understanding of factors controlling the growth, differen-tia-tion, integration, organization and survival of retinal transplants, with the long-term view of eventually developing retinal transplantation into a clinically useful procedure for treating degenerative retinal disorders such as retinitis pigmentosa. Embryonic day 15 rabbit retinas were transpl

Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. PMN are highly mobile cells that possess regulated mechanisms for controlling the expression and activation of adhe

This thesis explores links between psyche and soma in diabetes and in chronic benign pain (CBP). Interventions with Affect School and Script Analysis (ASSA) compared to Basic Body Awareness Therapy (BBAT) are tried. In a feasibility and treatment efficacy study we offered ASSA to 59 patients with CBP, and 54 (92%) completed. Alexithymia prevalence went from 33% to 11% (p = 0.013), depression from

Det huvudsakliga syftet med uppsatsen är att undersöka vilket skydd svensk lagstiftning stadgar mot barn- och tvångsäktenskap samt bakgrunden till detta skydd och hur skyddet förhåller sig till mänskliga rättigheter samt kulturella och religiösa normer kring äktenskap. Synen på äktenskapets syfte och ingående varierar stort mellan olika normsystem och är till stor del beroende av vilket samhälle

Uppsatsens primära syfte är att undersöka förekomsten och regleringen av rörliga ersättningar till ledande befattningshavare i svenska börsbolag. Ett första steg i besvarandet av frågeställningen är att utreda vad begreppet bolagsstyrning är. Termen är en översättning från engelskans corporate governance och definieras bland annat som ”ett system genom vilket företag styrs och kontrolleras”. En go

Den svenska produktionen av Science fiction-film är för många okänd. Uppsatsen undersöker vilka svenska filmer som kan klassas som science fiction och hur den svenska konstfilmsinstitutionen inverkat på produktionen. Med utgångspunkt i svenska science fiction-entusiasters sammanställningar, analyseras innehållet kvantitaivt i de långfilmer som gjorts och graderas i en tregradig skala efter hur sta

Med verkan från den 12 februari 2009 har Sverige regler som begränsar lånemöjligheterna från utländska företag. Lagstiftningen trädde formellt i kraft den förste januari 2010 och har införts till följd av att Skatteverket uppmärksammat en ökad aktivitet av skatteplanering innefattande utländska holdingbolag. Ägarledda svenska företag överlät sin verksamhet till ett egenkontrollerat utländskt holdi

Asthma and allergies are common diseases in adolescents and have increased during the last few decades. All elite level sports activities result in increased risk of asthma and rhinitis regardless of sport practised. Physical activity is at the same time regarded as a health-promoting factor and is recommended both for the prevention and treatment of diseases. The aim of this study was to explore

This thesis considers numerical simulations of high energy particle collisions, and improvements in the description of multiple collimated jets of hadrons in collision events in particular. In the event simulation software called event generators, the structure of multi-jet events is determined through an interplay of the input calculation, parton showers and phenomenological hadronisation models.

The control of cultivation conditions and its influence on growth and production have been investigated. The use of fed-batch processes have been demonstrated for several cultivation systems and so has the use of different control signals in these systems. Fed-batch cultivation of Pseudomonas cepacia with on-line measurement and control of the growth rate limiting (toxic) substrate, sodium-salicy

In vertebrates, studies of the aryl hydrocarbon receptor (AhR) have been of particular interest due to its direct involvement in the toxic effects exerted by several environmental pollutants, such as PCB and dioxin. After binding to the toxic molecule, this receptor initiates transcription of several genes that are part of the biotransformation battery but most notably the cytochrome P450 (CYP) ge

During total parenteral nutrition (TPN) adequate nutrition is provided intravenously and the enteral route is bypassed. The integrity of the gastrointestinal (GI) tract, however, is dependent on the passage of food through it. This thesis deals with the effects of TPN on the pancreas and the parotid glands. TPN induced hypotrophy of the exocrine pancreas and the parotid glands. The amylase concent

The terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. The tumour suppressor protein p53 is a transcription factor, and can induce cell cycle arrest and apoptosis of maligna

The aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. Paper I a