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Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with in

Ever since the term ‘gentrification’ was coined by Ruth Glass in 1964 this specific form of socio-economic change has attracted much attention within the social sciences, not least from geographers and sociologists. This has generated a rich discussion on the mechanisms behind the process and, to a lesser extent, a debate on positive and negative outcomes of gentrification. Critical voices have de

There is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. The indefinite expansion capacity of PSCs, combined with the possibility of creating these cells from patient-specific

Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to

This dissertation comprises a corpus-based study of the form and function of sentential object complements in Modern Standard Arabic (MSA). The study is motivated by the scarcity of investigations into MSA syntax as opposed to the syntax of Classical Arabic. Complements to three classes of complement-taking predicates (CTPs) ­ manipulation, cognition and utterance ­ are considered. The major part

The aim of this thesis was to study the morbidity and mortality of cardiovascular disease (CVD) in obese individuals, as measured by different obesity measurements, and to explore how the CVD risk related to obesity was modified by other biologic and socio-demographic circumstances. Data from two population-based cohort studies was used. The Malmö Preventive Project included 22 444 middle-aged me

This paper argues that there is reason to be skeptical about the idea that the transition to a service economy will bring about dematerialization of production and consequent environmental improvement. This is because the shift to a service economy is an illusion in terms of real production, but is instead generated by the fall in the price of manufacturing goods relative to services, which is in

The aim of this research was to clinically and experimentally evaluate the use of vacuum-assisted closure in poststernotomy mediastinitis after cardiac surgery. Vacuum-assisted closure (VAC) is a new wound-healing therapy based on the application of a local negative pressure to the wound. New techniques for treating poststernotomy mediastinitis are needed since conventional techniques have an unsa