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Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of h
Hormone refractory prostate cancer occurs when androgen-deprivation therapy (ADT) fails to stop the growth of prostate cancer for any longer. Recent studies point towards a role for neuroendocrine (NE) differentiation in the development of hormone refractory disease. It has been hypothesized that NE-differentiated malignant tumor cells survive during ADT and promote development of androgen-indepen
Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. Pharmacological agents to glutamate receptors at this synapse, (of which some are already clinically tested), could preve
This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. These cells have tremendous therapeutic potential to treat a variety of hematopoietic disor
All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. However, an alternative model has already been
Diabetes is a disease characterized by insufficient capacity to regulate the blood glucose level. In insulin-dependent diabetes, multiple daily injections of insulin have to be administered. In-between scheduled visits to the care provider, the patient has to manage the glucose control independently. Insulin dosing is a non-trivial task and many patients find it difficult. This is reflected in the
Popular Abstract in English The dissertation is divided into two parts. The first part deals with the development of a questionnaire diagnostic instrument for atopic dermatitis (AD). The second part concerns following a cohort and assessing the natural history of AD, in which the effect of specified risk factors is analysed. In Värmland, Sweden, a questionnaire that diagnoses AD in infants and preAbstract In childhood atopic dermatitis (AD) is the most frequent inflammatory condition. Validated eczema questionnaires have been available for schoolchildren only, but the incidence of atopic dermatitis is highest during infancy. Evidence is needed on the further development of asthma, and rhinitis in these infants with AD and on remission of AD in children. We aimed to validate a parental ques
Gestational diabetes mellitus (GDM) is associated with a risk of adverse pregnancy outcome and is a predictor of subsequent diabetes. The aims of this work were to describe a reliable routine to diagnose abnormal glucose tolerance during pregnancy, to investigate women’s opinions of the specialist care provided, to determine the prevalence of diabetes one year after giving birth, and to elucidate
Productivity of labour is particularly important especially in developing countries where most of the building work is still carried out on manual basis. Previous research has pointed out that productivity in the building industry is low and in some cases declining. Poor productivity of craftsmen is one of the causes of cost and time overruns on building projects. The objective of this research wa
Myocardial infarction (MI) following an acute coronary occlusion is a leading cause of morbidity and mortality. During revascularization, microemboli may complicate treatment and affect cardiac function. The long-term effects of microembolization are not fully elucidated. Following an MI it is important to accurately determine the size of the infarction, as it can be used for guidance in terms of
Seawater desalination constitutes an important water supply to the population bordering the Arabian Gulf, the Mediterranean Sea and the Red Sea. The three regions represent about 11.8% of the world land area and the countrieshosted approximately 9% of the world population in 1950 and 2008 and are also projected to do so in 2050. The results obtained for desalination capacity in the study area were
Post stroke shoulder pain, PSSP, is a common type of pain after stroke, but still further knowledge of this condition is needed. An increased knowledge of prevalence, contributing factors and impact on the individual’s life could enhance the possibility to find more effective treatments and therefore more studies are needed. The overall aim of this thesis was to evaluate PSSP with a special focus
In the developing process of medical devices three perspectives have to be considered; the users, the producers and the regulatory, still the user perspective is of special importance for the success of a product. At the same time possibilities are gradually reduced for medical technology companies to obtain new external ideas, mainly caused by the increased technical content of today’s medical de
Meniscus tears are common after knee injuries. The current treatment in patients under the age of 40 is typically arthroscopic partial meniscectomy (APM) or arthroscopic meniscus repair. Meniscus tears and surgeries are associated with an accelerated progression to knee osteoarthritis (OA) and disability. PAPER I is an observational cohort study, utilising the Skåne Healthcare Register (SHR) to id
An outpouring of scholarly editions: Media history perspectives on the editing of historical sources in Sweden, 1834–1847This article examines the scholarly editing of historical sources for publication in nineteenth-century Sweden. The analysis focuses on the approximately 500 letters exchanged between Hans Järta, the Director General of the National Archives of Sweden, and Bror Emil Hildebrand,
Abstract Fat bloom on chocolate is a major problem for the confectionery industry since the unappetising appearance and negative sensory effects lead to rejection by customers. The presence of fat bloom on chocolate confectionery systems is usually connected to migration of liquid fat due to the difference in composition between filling triacylglycerols (TAGs) and cocoa butter TAGs. The filling T
An important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly
