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Background and Methods: Signal-averaging ECG (SAECG), a bioelectrical processing method, is a further development of the conventional ECG. SAECG can detect voltage potentials in the microvolt range and provide a noise-reduced determination of QRS duration. Extended frequency spectra can be analysed. In adult patients after myocardial infarction it is used to predict the risk for arrhythmias and su
Principles for sensorimotor transformation and plasticity in the spinal cord and functional repair in the root-avulsed spinal cord were studied. A comparative study confirmed that the nociceptive withdrawal reflex (NWR) system is composed of reflex modules, with each performing a finely tuned transformation of skin sensory input to activity in one muscle. This suggests that modularity of the NWR s
Abstract One important task for the mental health services is to prevent suicidal behaviour, especially among persons at high risk, e.g. those who have attempted suicide. In two follow-up samples, one and three months after a suicide attempts, both n=97, we found that 32% and 38% of the patients respectively had no treatment and 30% in each sample had suicidal thoughts. In a randomised controlled
T lymohocytes (T cells) and B lymphocytes (B cells) are important effector cells of the adaptive immune system. In response to infections, B cells are activated and produce antibodies against specific antigens. There are two types of T cells, cytotoxic T cells that kill cells infected with bacteria or viruses, and helper T (Th) cells that help B cells produce antibodies by secreting cytokines as w
This thesis aims at characterizing the endothelin (ET) receptors in different vascular beds of man and rat. The ET-A receptor was shown to be the only contractile ET receptor present in all vascular regions, with the exception of the rat mesenteric vein where a weak ET-B receptor-mediated contraction was seen. Treatment with antisense oligodeoxynucleotides to the ET-A receptor mRNA during organ cu
The adult organization and postnatal development of the nociceptive withdrawal reflexes (NWR) of single hindlimb muscles were examined in decerebrate spinal rats using electromyography. In adult rats, NWR were found to perform highly organized sensorimotor transformations, with single muscles receiving excitatory cutaneous input from specific receptive fields (RF) whose distribution of sensitivity
The study of the protein complement of a genome is called proteomics. Proteomics can be defined as identification, quantification and characterization of a total set of proteins expressed at different time-points or under different cellular states to provide global information about biological processes. The study of membrane proteins is a challenging area in the development of proteomic research.
This thesis presents the results from a study of the first four years of diabetes in 879 patients aged 15-34 years at diagnosis. The aims of this study were to compare clinical classification with the presence of autoantibodies, to study the natural course of beta cell function during the first years of disease and to define predictive factors for the remaining beta cell function after diagnosis.
Orthostatic hypotension (OH) is believed to be an important cause of cerebral hypoperfusion, leading to chronic fatigue, blurred vision, unsteadiness, dizziness and sometimes syncope. It may also result in episodes of confusion, falls and fractures. The coupling between OH and organic dementia is not clear. Our findings in a large group of patients with Alzheimer's disease, vascular- and frontotem
The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. Cells used were human leukemic cell lines an
The vascular endothelium is an important regulatory organ in circulatory physiology and plays a central role in the response to acute inflammation and ischemia/reperfusion. Activation and dysfunction of the pulmonary vascular endothelium are closely related to clinical findings of pulmonary dysfunction. The endothelial-derived relaxing factor, nitric oxide (NO), is a gas, which can be administered
Hemicellulose is the second most abundant group of renewable polysaccharides. Mannans can be found as the major hemicellulose in softwood and as storage polysaccharides in a range of plants. In this work, structural and functional characterisations of family 5 and 26 endo-1,4-b-mannanases (b-mannanases) have been performed. These families belong to the large and diverse glycoside hydrolase clan A,
HERA-B is a high-energy physics experiment at HERA. It is a fixed-target experiment with a forward spectrometer to benefit from the strong boost of beauty hadrons. The main goal of HERA-B is to detect and measure the degree of CP violation in exclusive B-decays, with emphasis on the {em golden} decay, $golden$. A computer simulated study on this decay is presented and the accuracy of the measureme
It has been suggested that the cerebellar mossy fibre afferents transmit the conditioned stimulus (CS) information to the cerebellum. Several studies are consistent with this suggestion but alternative explanations have not been excluded. In conditioned ferrets, the forelimb CS was replaced by a direct stimulation of the cerebellar mossy fibre afferents. It was found that true conditioned response
I förarbeten till den svenska sexualbrottslagstiftningen anges att lagstiftningens huvudsakliga skyddsintresse är rätten till sexuellt självbestämmande och sexuell integritet. Den sexuella självbestämmanderätten betraktas ofta som antingen synonym med sexuell autonomi, eller som beroende av sexuell autonomi. Rätten till sexuellt självbestämmande skyddas genom att gränsen mellan straffbara och icke
