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Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines ar
The FUS gene at 16p11 fuses with DDIT3 and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the result of a t(16;21)(p11;q22) in acute myeloid leukemia. We here show that a t(7;16)(q33;p11) in two cases of low grade fibromyxoid sarcoma fuses the FUS gene to BBF2H7, a previously uncharacterized
The uptake and killing of bacteria by human neutrophils are dependent on the fusion of secretory granules with forming phagosomes. The earliest component of exocytosis was found to precede phagosome closure, so that granular membrane constituents were detectable on the plasmalemma. We show that during phagocytosis of IgG-opsonized particles, this early secretory response is highly polarized in the
Protein affinity reagents (PARs), most commonly antibodies, are essential reagents for protein characterization in basic research, biotechnology, and diagnostics as well as the fastest growing class of therapeutics. Large numbers of PARs are available commercially; however, their quality is often uncertain. In addition, currently available PARs cover only a fraction of the human proteome, and thei
The pre-Talpha (pTalpha[?]) gene encodes a protein that forms the pre-TCR together with the newly expressed TCR beta chain during a defined stage of early T cell development. The restricted expression of this gene has been suggested to depend on a promoter and an enhancer element containing E boxes, which are potential binding sites for basic helix-loop-helix (bHLH) proteins. We here report that i
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflam
The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote CD8 T cell-dependent anti-tumor immunity in pre-clinical cancer models. We found that T regulatory (Treg) cells infiltrating human or murine tumors expressed high amounts of 4-1BB.
In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in inf
Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and in
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci
Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ "writer" PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (I
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application an
Gene panel sequencing has become a common diagnostic tool for detecting somatically acquired mutations in myeloid neoplasms. However, many panels have restricted content, provide insufficient sensitivity levels, or lack clinically validated workflows. We here describe the development and validation of the Genomic Medicine Sweden myeloid gene panel (GMS-MGP), a capture-based 191 gene panel includin
fncel-14-00146.pdf REVIEW published: 29 May 2020 doi: 10.3389/fncel.2020.00146 Edited by: Sofia Grade, Institute of Molecular Biotechnology (OeAW), Austria Reviewed by: Daniel Tornero, University of Barcelona, Spain Afsaneh Gaillard, University of Poitiers, France *Correspondence: Anders Björklund anders.bjorklund@med.lu.se Specialty section: This article was submitted to Cellular Neuropathology,
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_frontiers.pdf - 2026-07-26
Habermas on the barricades Democratizing the Public Sphere Through Direct Action: a Case Study of Environmental Protest in Susa Valley, Italy BY FABRIZIO TROCCHIA fabrizio.trocchia@studio.unibo.it A thesis submitted in partial fulfillment of the requirements for Lund University International Master's Programme in Environmental Studies and Sustainability Science, LUMES, 2009 Supervised by: Turaj S.
https://www.lumes.lu.se/sites/lumes.lu.se/files/trocchia_fabrizio_thesis_2009.pdf - 2026-07-26
3D biomaterial models of human brain disease Neurochemistry International 147 (2021) 105043 Available online 20 April 2021 0197-0186/© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 3D biomaterial models of human brain disease Janko Kajtez a,*, Fredrik Nilsson a, Alessandro Fiorenzano a, Malin Par
Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ The Great Convergence? Gender and Unpaid Work in Europe and the United States ARIANE PAILHÉ, ANNE SOLAZ, MARIA STANFORS LUND PAPERS IN ECONOMIC DEMOGRAPHY 2020:1 Copyright is held by the author(s). Lund Papers in Economic
https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2020_1.pdf - 2026-07-26
Microsoft Word - ANTAGNINGSORDNING beslut US 2024-06-18 test Sida 1 av 28 Universitetsstyrelsen BESLUT Diarienummer I G 9 6251/2004 LS 2012/719) STYR 2017/409 STYR 2024/288 Datum 2024-06-18 Innehåll Antagningsordning för utbildning på forskarnivå vid Lunds universitet 1. Inledning .................................................................................. 3 2. Information om ledig utbildnin
Literature COSM35_2021 Autumn Literature for COSM35 Digital Asia Master Program in Asian Studies, Lund University Digital Asia is one of the elective courses in the third semester of the master's program (but it can also be stand as a single course). The course integrates general studies on Internet/social media with Asian studies. Literature has been chosen that reflects this and addresses critic
https://www.ht.lu.se/media/utbildning/dokument/kurser/COSM35/20212/COSM35_literature_2021.docx - 2026-06-29
