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BackgroundWomen are at a greater risk of a major adverse cardiovascular event (MACE) after percutaneous coronary intervention than men. A history of preterm delivery is a female-specific risk factor for coronary artery disease, but its relevance in the treatment of coronary artery disease is unknown.ObjectivesThe purpose of this study was to analyze the association between a history of preterm del
Alternative Economic Models (AEMs) are theoretical frameworks that, if implemented, could fundamentally transform economic systems by aligning financial objectives with sustainability goals. Conducting rigorous research on future-oriented AEMs and other complex sustainability systems presents challenges, particularly due to the exploration of largely unverifiable future possibilities. Qualitative
Over the past few decades, digital methods of documentation and exhibition have been becoming ever more popular in museums. As technologies advance, so too do the implications for museum digitization. This thesis provides a glimpse into the current atmosphere of museum digitization, proposes new applications for digital documentation and propagates these themes through the development of a case st
Large-scale science research facilities, such as those for investigation into the smallest components of physical matter, often consist of buildings with quite extraordinary features as regards shape and scale. These architectures are semiotically interesting in several ways: they have extraordinary outer forms that reflect the their inner activities; they require forms of mediation and planning t
Kandidatuppsatsen undersöker effekterna av buzzwords inom informatikforskning; den granskar hur dessa termer formar forskningsagendor, metoder och gemenskapsidentiteter genom Social Identity Theory. Studien använder en kvalitativ forskningsansats där data samlades in genom intervjuer från medvetet utvalda akademiker inom informatikområdet och analyserades tematiskt, vilket ledde till slutsatsen om
Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, suc
PURPOSE: Accumulation of oxidized LDL in the arterial wall is believed to play a key role in the development of atherosclerosis. Experimental studies have identified the presence of immune responses against epitopes in oxidized LDL that protects against atherosclerosis. We have produced human recombinant IgG against one of these epitopes (aldehyde-modified apoB-100 amino acids 661-680) and demonst
In recent years, the discourse of ‘relevance’ has risen to prominence in the university-based business school. At the heart of this discourse is the suggestion that management researchers should align their research practices more closely with the needs of practitioners in external organizations. One important but under-researched strand of this debate focuses on the way in which ‘relevance’ is pu
MAX-lab is a Swedish national synchrotron radiation facility, first established as a small-scale university project in the late 1970s and then gradually developed into a national and international user facility. This article presents a historical study of MAX- lab that illustrates the decentralized character of the Swedish science policy system and especially its lack of aggregation mechanisms for
Introduction. The aetiology and pathogenesis of ulcerative colitis (UC) are essentially unknown. Galectins are carbohydrate-binding lectins involved in a large number of physiological and pathophysiological processes. Little is known about the role of galectins in human UC. In this immunohistochemical exploratory study, both epithelial and inflammatory cell galectin expression were studied in pati
OBJECTIVES: To examine whether the decrease in IMT progression rate in the carotid bulb induced by metoprolol CR/XL treatment (25mg once daily) observed in the β-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS) was accompanied by an effect on carotid plaque echogenicity. METHODS: Gray scale median (GSM) in carotid plaques, used as a score of echogenicity, was measured at baseline and
Objective. To construct a database for clinical epidemiological prostate cancer research based on linkages between the National Prostate Cancer Register (NPCR) of Sweden, a population-based, nationwide quality database, and other nationwide registries. Material and methods. By use of the individually unique Swedish Personal Identity Number, the NPCR was linked to the Swedish Cancer Registry, the C
The ability to capture alterations in the genome or transcriptome by next-generation sequencing has provided critical insight into molecular changes and programs underlying cancer biology. With the rapid technological development in single-cell sequencing, it has become possible to study individual cells at the transcriptional, genetic, epigenetic, and protein level. Using single-cell analysis, an
Twenty years have passed since the Brundtland report launched the goal of “sustainable development” (SD). During these decades SD has become widely accepted and it is today established as a fundamental goal in most policy contexts at the international level as well in many countries, regions and cities. A growing research community focussing on various aspects of sustainable development has develo
Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challeng
