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While prostate cancer (PrCa) is highly heritable, the genes associated with PrCa survival after diagnosis remain poorly understood. We aimed to identify genes associated with PrCa-specific survival through transcriptome-wide association studies (TWAS) using genetic predictors of gene expression in the prostate. We used the Transcriptome-Integrated Genetic Association Resource (TIGAR) to train expr

Recent discussions of method in historical Jesus research have called into question the use of criteria for evaluating the authenticity of Gospel material. The present article lays out the reasons why a number of scholars call for an abandonment of the so-called criteria approach and then criticizes the allegation that this approach is genetically and logically dependent on form criticism. By anal

Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. Mutations in si

This topic of this thesis is how the presence of biomembrane molecules affect the behavior of a protein related to Parkinson’s disease in a simplified (compared to in the cell) model system.Lipids are fat molecules that make up the biological barriers in our body that control transport of essential molecules in and out of the cell and create an environment where membrane proteins can perform their

Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. The most effective treatment for PD is the DA precursor, L-DOPA. Unfortunately, within a few years, L-DO

Objectives: Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD) have been published. In EMERGE, but not in ENGAGE, high-dose aducanumab demonstrated significant treatment effects across primary and secondary endpoints. Low-dose aducanumab results were consistent across studies with non-significant differ

This article addresses the ethical and epistemological challenges of interdisciplinary efforts through the interactional lens of proximity. How can we ensure interdisciplinarity in unequal institutional, disciplinary, and geopolitical environments? What does it mean to do research when epistemological frameworks clash between fields and sectors? Which echo chambers are perpetuated when we limit in

There is a need to develop and use research observations in the clinical field, primarily to gain insight into and assess evidence of what comprises caring in a real-life situation and confirm what is actually taking place. In addition, assessments lead to a new and different understanding of what caring constitutes, thereby enabling the identification of what kind of care is being provided and is

Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-ana

The Earth System Science Partnership, which unites all major global change research programmes, declared in 2001 an urgent need to develop "strategies for Earth System management". Yet what such strategies might be, how they could be developed, and how effective, efficient and equitable such strategies would be, remains unspecified. It is apparent that the institutions, organizations and mechanism