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Background Advances in medical and surgical care have improved survival in patients with transposition of the great arteries (TGA), shifting focus toward quality of life (QoL). In this study we evaluate QoL in adults with TGA, including congenitally corrected TGA (ccTGA) and patients with dextro-TGA (d-TGA), by comparing patients with a systemic right ventricle (sRV) and systemic left ventricle (s
High-altitude lakes and headwater streams of the Andes provide essential benefits to society, yet they remain among the least studied and most vulnerable freshwater ecosystems. These systems supply drinking water, support agriculture and grazing, regulate floods, store carbon, and hold deep cultural and spiritual value for local communities. However, climate change, land use change, water extracti
Critical events frequently occur in hospital settings. Cinematic portrayals of medicine and medical environments can illuminate historical developments and perspectives on healthcare, medical professions, and specialisations. This article aimed to explore the interplay between structural framework, professional, and relational factors when facing critical events and their management in a hospital
The transition toward a circular economy is driving rapid growth in the recycling sector, yet occupational exposure remains poorly characterized, including exposure to phthalates and bisphenols. We conducted a human biomonitoring study among recycling workers handling e-waste, metal waste, and mixed waste in Sweden. The study included 114 exposed workers, 23 low-exposed workers, and 18 controls. P
This study aimed to determine the effects of advanced glycation end products (AGEs) on endothelial cytoskeleton morphology and permeability, and to detect the underlying signaling mechanisms involved in these responses. Cultured endothelial cells (ECs) were exposed to AGE-modified human serum albumin (AGE-HSA), and EC cytoskeletal changes were evaluated by observing fluorescence of F-actin followi
Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of
This paper presents a methodological approach for the study of volatile organic compounds (VOCs) in air, emitted during storage of municipal solid waste in bales. Determination of VOCs was based on sampling with adsorbent tubes followed by automated analysis using on-line work-up with a thermal desorption unit directly connected to a gas chromatograph-mass spectrometer. Using calculation algorithm
Context: Previous randomized trials have suggested an association between radioiodine treatment for Graves' hyperthyroidism and thyroid-associated ophthalmopathy (TAO). Objectives: The aim of the study was to compare the occurrence of worsening or development of TAO in patients who were treated with radioiodine or antithyroid drugs. Design: We conducted a randomized trial (TT 96) with a follow-up
Popular Abstract in Swedish Denna avhandling behandlar frågor om normbildning och argument för gemenskap i den svenska statsmaktens officiella retorik från 1660-1919. Varje nytt år skulle befolkningen i Sverige lyssna till de böndagsplakat som lästes upp i rikets kyrkor. Där informerades om riksdagar och gavs förklaringar till krig och kriser. Där beskrevs även grunden för rikets gemenskap och SveThis study deals with questions about norm building and arguments for community in official royal rhetoric in the Swedish realm from 1660 to 1919. Every year, an intercession day proclamation issued by the King in Council (Kungl. Maj:ts böndagsplakat) was read out from pulpits across Sweden. Like many communiqués, they belonged to the proclamation system, which included the spreading of informatio
The objective of this study was to isolate fibrotic cells from human lung biopsies taken from different central pulmonary locations. A comparison was made of cell morphology, proteoglycan- and protein-expression in mesenchymal cell cultures obtained from human bronchial biopsies from patients with asthmatic-like disorders. We isolated viable cells from 10 out of the 12 biopsies. The fibroblast-lik
Background: A major part of medical pathology in internal medicine is associated with chronic alcoholism. The aim of the current study was to investigate whether screening for Alcohol Use Disorders (AUD) can be improved through determination of direct ethanol metabolites compared to traditional biological state markers, the Alcohol Use Disorders Identification Test (AUDIT) and additional self-repo
The peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear hormone receptor superfamily, is essential for adipocyte differentiation and glucose homeostasis. PPARgamma has been found recently to regulate macrophage activation in response to mitogens and inflammation. Our study shows PPARgamma to be preferentially expressed in the nuclei of resting T cells and to incre
A survey was made of the current status of treatment of haemophilic boys at 20 centres in 16 European countries and includes approximately 1500 of the estimated 6500 haemophiliacs in the participating countries. Many mild haemophiliacs are not seen, or seen infrequently, at haemophilia centres and this requires study. Nine of 18 centres provide continuous prophylaxis to 80-100% of their patients,
Problem discussion: Syncron experience a challenge in realizing the full market potential of its newly developed IT-based price management system, Global Price Management (GPM). The system has already been implemented and is currently running with success within the IT-structures of the first customer. The fact that the development of the system has been initiated by a customer, and thereby has le
Background and aims: Gambling disorder (GD) is a behavioral addiction often co-occurring with various mental health concerns, such as problematic pornography use (PPU). The specific impact of the co-occurrence of GD and PPU on treatment outcome remains underexplored. This study aimed to compare the treatment outcomes of individuals actively receiving treatment for GD (n = 172; 3.49% females), dist
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Atherosclerosis, a chronic pathology directly related to the circulatory system, develops due to an interplay between several molecular events. Atherosclerotic plaque build-up can lead to a reduction in arterial blood flow and finally, myocardial infarction (MI). To prevent or slow down of the CVD progression, it is impo
Purpose: Predictive biomarkers are needed to aid the individualization of radiotherapy (RT) in breast cancer. Cancer-associated fibroblasts have been implicated in tumor radioresistance and can be identified by platelet-derived growth factor receptor-beta (PDGFRb). This study aims to analyze how PDGFRb expression affects RT benefit in a large randomized RT trial. Methods: PDGFRb was assessed by im
Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a genome-wide association study totalling 5,320 cases and 422,289 controls from four Nordic populations, and find a novel MM risk variant at SOHLH2 at 13q13.3 (risk allele frequenc
Purpose – The aim of this paper is to contribute with increased knowledge of the complex role of internal communication during a crisis like the COVID-19 pandemic. More specifically, the authors want to address the following research questions. How can the overall approach to internal crisis communication during the pandemic be interpreted, and what view of internal crisis communication does this
Background: Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but based on previous randomized controlled trials and observational studies, there are still uncertainties about the safety in giving low-grade RBC transfusions to patients with sep
