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Rap1 is the main protein that binds double-stranded telomeric DNA in Saccharomyces cerevisiae. Examination of the telomere functions of Rap1 is complicated by the fact that it also acts as a transcriptional regulator of hundreds of genes and is encoded by an essential gene. In this study, we disrupt Rap1 telomere association by expressing a mutant telomerase RNA subunit (tlc1-tm) that introduces m

BACKGROUND AND PURPOSE: In total knee arthroplasty (TKA), metal-backed (MBT) and all-polyethylene (APT) designs have shown comparable implant migration up to 2 years postoperatively using radiostereometric analysis (RSA). However, studies comparing mid-term migration of both designs are lacking. Furthermore, continuously migrating TKAs up to 2 years may continue to migrate or stabilize thereafter.

Universities are a relevant and little-explored context to the study of strategic action, considering their need to adapt to environmental dynamics and establish a closer relationship with society. This study contributes to shedding light on how the changing process from a traditional university model to a more entrepreneurial model takes place. Thus, this study aims to analyze the role played by

Objectives To describe the first-in-man experience with the ClearLumen Thrombectomy System (Walk Vascular, Irvine, CA) and report on its safety, feasibility and efficacy when used as an adjunctive therapy during primary PCI. Background Thrombus aspiration (TA) aims to improve microvascular perfusion but currently available devices are not optimal. Methods Prospective, single-centre, non-randomized

The development of electrical resistivity imaging techniques has been rapid in the last decade. This applies to data acquisition as well as inverse modelling techniques, and has lead to a greatly expanded practical applicability of the method. A trend today is to move from traditionally used electrode array types towards non-conventional arrays that are more efficient for multi-electrode equipment

A voltage reference has been implemented in a standard 0.35 μm CMOS process. A temperature coefficient of 12 ppm/°C is achieved in virtue of a complete suppression of the temperature dependence of the carrier mobility. The line sensitivity is 0.46 %/V and the maximum supply current, measured at 80°C, is 130 nA. The PSSR at 100 Hz and 10 MHz is -59 dB and -52 dB, respectively.

The formation of platoons, where groups of vehicles follow each other at close distances, has the potential to increase road capacity. In this paper, a decentralized control approach is presented that extends the well-known constant headway vehicle following approach to the two-dimensional case, i.e., lateral control is included in addition to the longitudinal control. The presented control scheme

SPECT projections are contaminated by scatter, resulting in reduced image contrast and quantitative errors. When tissue is present behind the source, some of the detected photons backscatter via this tissue. Particularly in dual-isotope SPECT and in combined emission-transmission SPECT, backscatter constitutes a major part of the down-scatter contamination in lower-energy windows. In this paper, t

The paper presents a fed-batch fermentation technique for bioreactors operating close to their maximum oxygen transfer capacity. The method combines the advantages of the probing feeding strategy and the temperature limited fed-batch technique. When the maximum oxygen transfer capacity of the reactor is reached, the temperature is decreased to lower the oxygen demand. To achieve a good control of