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To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MMP-generated aggrecan G1 fragments terminating in VDIPEN341 were compared with the distribution of aggrecanase-generated G1 fragments terminating in NI
Objective To evaluate a calibration method for disk diffusion antibiotic susceptibility tests, using zone diameter values generated in the individual laboratory as the internal calibrator for combinations of antibiotic and bacterial species. Methods The high-zone side of zone histogram distributions was first analyzed by moving averages to determine the peak position of the susceptible population
Due to electrification, new demands are imposed on gears regarding e.g., quality, noise, lubrication, and gear ratio.Therefore, a better understanding of gearset meshing and operation is needed. Experiments are valuable tools, butalso tend to be cumbersome and time consuming. Moreover, contact pressure cannot be measured satisfactorily.Thus, a simulation tool is needed. In this thesis, an LTCA sim
INTRODUCTION: Parents can act as important agents of change and support for healthy childhood growth and development. Studies have found that parents may not be able to accurately perceive their child's weight status. The purpose of this study was to measure parental perceptions of their child's weight status and to identify predictors of potential parental misperceptions.METHODS: We used data fro
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING (Popularized summary in Swedish) Monoaminer Monoaminer såsom serotonin, dopamin, noradrenalin, adrenalin och histamin är alla signalsubstanser syntetiserade från enkla aminosyror. Nervceller som innehåller monoaminer är anatomiskt lokaliserade till hjärnstammen och förlängda märgen. Härifrån försörjer de resten av storhjärnan samt ryIn the present study, the mRNA encoding the serotonin transporter (5-HTT) and two isoforms of the vesicular monoamine transporters (VMAT1 and VMAT2) have been mapped in the rat throughout gestation and early postnatal development using in situ hybridization, RT PCR and immunohistochemistry. 5-HTT mRNA was found in serotonergic neurons and VMAT2 mRNA in all monoaminergic neurons from early gestatio
Every car has its own cornering dynamics, some are oversteered, meaning that they respond more to a steering input, and some are understeered, responding less to a steering input. These dynamics depend on a wide range of parameters, the size and weight of a car and the distribution of the weight to name a few. The main part of this thesis is aimed at controlling the cornering dynamics. More specif
The propagation of premixed reacting waves can be characterized by a displacement speed Sd at which the local surface of the reaction progress scalar moves respective to flow. Often, Sd is considered through decomposition into three parts of contribution due to the tangential diffusion of curvature, normal diffusion, and reaction. A set of recently derived transport equations for Sd and three of i
Introduction: Recovery following distal radius fracture (DRF) is generally achieved within six months. However, a minority of patients experience functional impairments over a longer period. Traditional outcome measures are grip strength and range of movement. However, this may not reflect all parameters that are important. This study focuses on grip function as well as occupational performance in
PURPOSE: To report the change over time in intraocular pressure in patients treated with topical timolol or placebo.METHODS: Ninety patients with untreated ocular hypertension, defined as elevated intraocular pressure and normal visual fields, were randomly assigned to treatment and prospectively observed at 3-month intervals for up to 10 years in a double-masked fashion. The study end point was o
Whether chromosome abnormalities observed in tumor cells may in some cases reflect low-grade somatic mosaicism for anomalies present already at zygote formation, rather than acquired somatic mutations, has for long remained a speculation. We here report a patient with Wilms tumor, where constitutional somatic mosaicism of trisomy 8 was detected in a previously healthy 2 ½-year-old boy. Single Nucl
The attachment of primary rat hepatocytes and fibroblasts to collagen type I is mediated by non-RGD-dependent beta 1 integrin matrix receptors. In this report we describe a novel 96-well microtiter plate assay for the quantification of fibroblast-mediated contraction of floating collagen type I gels. Fetal calf serum and platelet-derived growth factor (PDGF), but not transforming growth factor-bet
Purpose To evaluate the image quality of clinical radiographs with two different methods, and to find correlations between the two methods. Methods Based on fifteen lumbar spine radiographs, two new sets of images were created. A hybrid image set was created by adding two distributions of artificial lesions to each original image. The image quality parameters spatial resolution and noise were mani
Pseudoachondroplasia (PSACH) is one of the more common skeletal dysplasias and results from mutations in cartilage oligomeric matrix protein (COMP). Most COMP mutations identified to date cluster in the TSP3 repeat region of COMP and the mutant protein is retained in the rough endoplasmic reticulum (rER) of chondrocytes and may result in increased cell death. In contrast, the pathomolecular mechan
When radio-iodine was first used in the treatment of metastasized thyroid carcinoma in 1943, its success in terms of tumour response, quality of life improvement and survival was considered a 'miracle', as in those days metastatic cancer was generally fatal. Inspired by this, many efforts have been made to apply radioisotope therapy to other tumours. Radionuclide therapy uses radioactive isotopes
This paper presents a structured methodology for the constrained multi-objective optimization (MO) of a continuous cross-flow atomic layer deposition (ALD) reactor model with temporal precursor pulsing. The process model has been elaborated and experimentally validated in the first two papers of this series (33 and 34). A general constrained MO problem (MOP) was formulated to simultaneously optimi
One of the biggest question in physics is to investigate the early universe or big bang. 10 µs after big bang, there existed a phase of transition called QGP (Quark Gluon Plasma). In this phase of transition quarks and gluon were free from each other. In normal life neutron and proton consist of three quarks with exchanging gluons. To simulate QGP scientists has built the large accelerator at CERN
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
Allt sedan Öresundsbron öppnades år 2000 har både pendlingen över landsgränserna och integrationen i Öresundsregionen gått stadigt framåt. Det pendlas dagligen fram och tillbaka från bostaden i det ena landet till arbetet i det andra, framför allt är pendling över landsgränsen från bostaden i Sverige till arbetet i Danmark omfattande. Det finns alltid en risk för att en inkomsttagare blir dubbelThe commuting and the integration in the Öresund region have progressed ever since the bridge between Denmark and Sweden opened up for traffic in the year of 2000. Every day commuting across the border from the residence in one country to the place of work in the other country is taking place. The commuting between the residence in Sweden to the place of work in Denmark is the far most frequent.
