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Protein Complexity via Non-Native States: Binding, Stability, and Structural Studies of Calbindin D9k and HAMLET (Human alpha-lactalbumin Made LEthal to Tumor cells).

Popular Abstract in Swedish Kalcium är inblandat i många viktiga processer i kroppen. Kalciumbindande proteiner är viktiga i detta sammanhang. Det finns ofta en vattenmolekyl med på bindningsstället i proteinet och vi har studerat hur den påverkar bindningsegenskaperna. Kalcium är inblandat i många viktiga processer i kroppen. Kalciumbindande proteiner är viktiga i detta sammanhang. Jag har studeUsing optical spectroscopy, nuclear magnetic resonance (NMR), and differential scanning Calorimetry (DSC), I have studied two different calcium binding proteins that can form kinetically trapped altered states. Calcium is very important in numerous biological processes such as blood coagulation, signal transduction, muscle contraction and bone formation. Calcium binding to proteins regulates these

Johannes Magnus and the Composition of Truth : Historia de omnibus Gothorum Sueonumque regibus

Johannes Magnus (1488–1544) was the last Catholic archbishop of Uppsala to hold residence in Sweden. He was also a historian and wrote a work in Latin about Swedish history that was to gain an unparalleled importance. The work is entitled Historia de omnibus Gothorum Sueonumque regibus, the ‘History of all the Kings of the Goths and the Swedes’. It is arranged as a series of biographies of over 20

On the importance of farmland as stopover habitat for migrating birds

Agricultural intensification has led to dramatic population declines among many farmland bird species. Negative effects of intensive farming in terms of decreased local habitat quality or structural simplification of farmland landscapes have reduced both reproductive outcome and winter survival of many species. Studies investigating agricultural effects on migrating birds using farmland as stopove

Stimulus-Section Coupling in Endocrine Cell Models

Detailed understanding of biological systems governing specific mechanisms and pathways is essential in the development of novel disease therapies. Stimulus-secretion coupling in hormone secreting cells is a complex system of pathways that link activation of cellular processes by i.e. nutrients to the release of hormone. Stimulus-secretion coupling in the insulin secreting beta-cell is intensely r

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Abstract in UndeterminedAbstractThe aim of this study is to investigate the structural licensing and the semantics of the dative-DP in ditransitive constructions in German from a cognitive and construction grammar perspective.While the indirect object in constructions with prototypical ditransitive verbs is said to be a lexically selected argument of the verb, the indirect object in beneficiary di

Direct Conversion of Human Fibroblasts to Induced Neurons

Popular Abstract in Swedish Celler som har förmågan att ge upphov till nästan alla typer av mogna celler i en organism kallas för pluripotenta stamceller. Förutom deras förmåga att bilda olika specialiserade celltyper har pluripotenta stamceller även den unika förmågan att genomgå ett obegränsat antal celldelningar. Under utvecklingen av en organism genomgår pluripotenta stamceller en process som

The role of gamma-tubulin in cell division and cancer

Although cancer is a heterogeneous disease, a common theme in tumor cells is the deregulation of cell division, which renders tumor progression independent of otherwise necessary internal or external growth cues. This may provide cancer cells with the ability to divide indefinitely, posing a threat to the rest of the organism. As the tumor grows, nearby healthy tissues are harmed, which eventually

Ecology and conservation of the moth Dysauxes ancilla

Popular Abstract in Swedish Ekologin hos lavdagsvärmaren (Dysauxes ancilla) studerades inom den enda svenska populationen vid Beijershamn på Öland. Populationen utgör en isolerad förekomst på nordgränsen av artens utbredningsområde, som huvudsakligen är mellan- och sydosteuropeiskt. Arten är rödlistad som akut hotad. Resultaten visar att lavdagsvärmaren för närvarande endast förekommer inom ett 4 The ecology of the moth Dysauxes ancilla was studied in the only Swedish breeding area at Beijershamn, situated on the Baltic island of Öland. The population is a northern outpost, separated from the species´ continous distribution area in middle- and southeast Europe. There is a general opinion that there has been a reduction of the species distribution during the last decades, but no studies hav

Kampen om högt och lågt. Studier i den sena nittonhundratalsromanens förhållande till masskulturen och moderniteten

Popular Abstract in Swedish Det är en utbredd uppfattning att gränserna mellan högkulturen och masskulturen blivit mindre skarpa i vår postmoderna kultur. Den höga litteraturen lånar friskt former, motiv och grepp från masskulturen – och viceversa. Hur skall man tolka den estetiska trafiken mellan kulturella sfärer – höga respektive låga – som länge ansetts oförenliga? Vad består trafiken av och The Struggle for High and Low Culture. Studies in the Late Twentieth Century Novel’s Relationship to Mass Culture and Modernity. It is a widespread opinion that the boundaries between high culture and mass culture have become less defined in our postmodern culture. How is the aesthetic exchange to be interpreted between cultural spheres – high and low respectively – long considered incompatible?

Iconoclasm. The destruction and loss of heritage reconsidered.

In 2001, when the Taliban decided to destroy numerous cultural artefacts, including two colossal Buddha statues, that they considered incompatible with their faith, a large outcry was heard across the Western world. From the UNESCO to the British Museum, and from the Dalai Lama to countless head of governments, all were united in condemning this act of ’cultural terrorism’ that was said to prove n

Evolutionary dynamics of migration and breeding in wild birds: genetic architecture, sexual conflicts and evolutionary constraints

Popular Abstract in Swedish När vi ser oss omkring i naturen är det lätt att överväldigas av den otroliga variationen i olika former, färger och mönster som förekommer. Var kommer all denna variation ifrån? Samma fråga ställde sig Charles Darwin för mer än 150 år sedan – svaret publicerade han 1859 i sin bok ”Om arternas uppkomst”. Evolution är den process som genom selektion gynnar vissa egenskap

Ecology of red admiral migration

The red admiral (Vanessa atalanta) is a migratory butterfly that can be found in North America, North Africa, Europe and some parts of Asia. In Europe the main part of the population spend winter in the Mediterranean region and the following spring leave this area to breed further to the north. At least one new generation is then produced in the summer region before they return to the south again

Epidemiology and population structure of Campylobacter jejuni and related organisms in wild birds

Campylobacter jejuni is one of the most common causes to bacterial gastroenteritis in the industrialised world. Also other species of the Campylobacter genus give rise to human infections. C. jejuni occurs in many different animal hosts and can be isolated from water sources. This thesis deals with the occurrence and population structure of this bacterium and related organisms in wild birds. Using

Male and female selective mechanisms, reproductive success and gene flow

In this thesis, I have studied male and female selective mechanisms that can affect plant reproductive success and gene flow. I have focussed on sexually selected traits, mainly pollen competition and maternal sorting mechanisms, for example through non-random ovule abortion. The main question was; what kind of traits can influence the most successful pollen donor or maternal sorting process? I fo

Costs in the ecology and evolution of the vertebrate immune system

Popular Abstract in Swedish Trots att vi har ett mycket sofistikerat immunförsvar är infektionssjukdomar ett stort problem för alla flercelliga organismer. Varför har vi inte under evolutionens gång lyckats finna ett sätt att överlista virus, bakterier och andra parasiter? En förklaring är att immunförsvaret är kostsamt, dvs att ett kraftfullt immunförsvar inte bara ger fördelar i form av ökat sky

Food Quality for Zooplankton in Humic Lakes

Food quality affects growth, reproduction and community structure of zooplankton, and has implications for nutrient cycling and the transfer of energy and matter in aquatic food chains. While the issue of food quality in clear water lakes has received great recent attention, studies on food quality for zooplankton in humic lakes are scarce. Humic lakes are largely influenced by carbon of terrestri

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This thesis deals with the information-structural problems native speakers of Swedish have when producing texts in German as their second or foreign language (L2). The study is based on written production data from Swedish learners of German at the initial state (14-year-olds), at intermediate level (16-year-olds) and at advanced level (20-25-year-olds). These data are compared with Swedish and Ge

Hälsovägledning i barnhälsovården : syntetisering av två uppdrag

Popular Abstract in Swedish Denna studie fokuserar på distriktssköterskors hälsovägledning i barnhälsovården. Syftet med studien är att öka förståelsen för hur hälsovägledning utformas och genomförs, samt att generera teori, användbar för praktisk barnhälso-vårdsverksamhet. Data samlades in genom videoobservationer med efterföljande intervjuer, fältanteckningar, anteckningar från gruppdiskussionerChild Health Services (CHS) form a strategic arena for Swedish health promotion, from a societal as well as individual perspective. The present study focuses on district nurses´ health counselling in CHS. The aim is to improve understanding of what is important in shaping and accomplishing health promotion, and to generate theory useful in a CHS context. Data were collected at CHS in primary healt