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DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TLK1/TLK2) to chromatin assembly and maintenance of replication fork integrity. We show that TLK activ
This work presents the architecture of a prototype software system for image preprocessing and analysis designed to support the guidance of an auxiliary UAV camera. The study begins with an overview of typical UAV onboard elec-tronics, highlighting the electro-optical equipment, which includes a navigation camera and an auxiliary camera with a narrower field of view. Automatic image analysis from
Much scholarship has critiqued the fact that non-governmental organisations (NGOs), as a result of global neoliberalism and consequential state retreat, have become private service providers of children’s protection rights. But how can we explain the situation when neoliberal states also undergo autocratisation and take back service provision from NGOs, while at the same time preserving the privat
Background: Age-related immunosenescence, also known as ‘inflammageing’, may impact the elderly’s ability to mount immune responses against cancers and compromise the effectiveness of immune checkpoint inhibition (ICI). In this context, data on tonsillar cancer (TC), a subset of head and neck squamous cell cancer (HNSCC), are lacking. Aims/objectives: To compare the presence/distribution and featu
The total potential energy surfaces of several thallium, gold, iridium and rhenium odd-mass isotones are calculated microscopically as functions of the quadrupole deformation epsilon 2, when the odd protons occupy definite orbitals. The nuclear shapes and the static equilibrium deformations of these nuclei are deduced from the results of these calculations for the proton orbitals nearest to the Fe
Creating thermally stable collagen mimetic peptides (CMPs) is a persistent challenge. Nature leverages covalent crosslinkings to stabilize collagen's signature triple helical tertiary structure and higher-order assemblies. Herein, crosslinkings between levodopa (Dopa) and lysine can covalently stabilize the triple helix in CMPs is demonstrated. Since alkaline conditions catalyze the oxidation of t
Computational analysis of large-scale metagenomics sequencing datasets provides valuable isolate-level taxonomic and functional insights from complex microbial communities. However, the ever-expanding ecosystem of metagenomics-specific methods and file formats makes designing scalable workflows and seamlessly exploring output data increasingly challenging. Although one-click bioinformatics pipelin
This article presents a Luhmann-inspired theory of conflictualization, that is, how objects, relations, and societies come to be defined by the logic of conflict. This article presents a Galtung- and Luhmann-inspired theory of conflictualization, that is, how objects, relations, and societies come to be defined by the logic of conflict. The article conceptualizes conflictualization as a threefold
Sensor degradation poses a significant challenge in autonomous driving. During heavy rainfall, interference from raindrops can adversely affect the quality of LiDAR point clouds, resulting in, for instance, inaccurate point measurements. This, in turn, can potentially lead to safety concerns if autonomous driving systems are not weather-aware, i.e., if they are unable to discern such changes. In t
Regenerated silk fibroin (RSF), obtained from the silk fibers of the species Bombyx mori, is a promising biomaterial due to its excellent mechanical and biological properties, as well as presenting versatility for applications in tissue engineering. This is particularly evident through the development of scaffolds via the 3D printing process. The viscosity of RSF solutions can be controlled by add
Shared housing is a rather unusual phenomenon in Sweden. However, due to the decreasing availability of affordable housing and a large share of single-person households in urban areas, sharing is on the rise and new forms of shared housing have entered the market. By analysing how shared housing overlaps with existing patterns of socioeconomic segregation and by interviewing developers of diverse
Background: Despite the rapid pace of assistive robotics development, adoption of these has been limited. This raises questions such as: What contributes to this low uptake? What strategies could be employed to increase uptake? What guidance can be found in the literature to inform alternative approaches or directions for development?Objective: This critical narrative review sheds light on the dev
Advancing the use of air-sensitive polar organometallic Grignard and organolithium reagents under more environmentally benign conditions, here we report the addition of these reagents to a-b unsaturated ketones and aldehydes using the deep eutetic solvent (DES) choline chloride (ChCl): glycerol (Gly) (1:2), under air. Reactions occur at room temperature within seconds with excellent regioselective
Aim: To describe what is known about hip problems in individuals with developmental central hypotonia. Method: Searches were conducted in five databases to October 2023. Down syndrome was excluded from this analysis of less well-known genetic diagnoses. At least two reviewers independently screened titles, abstracts, read full-text articles, and extracted data. Results: Of 89 full-text articles, 7
In September 2024, I started creating a performance entitled Encruzilhada, based on my understanding of carrego colonial (colonial burden), a concept elaborated on by Brazilian pedagogue Luiz Rufino in his work Pedagogia das Encruzilhadas (Pedagogy of the Crossroads). Encruzilhada concentrates on the production of an ebó (offer, sacrifice) to Exu. The ebó, in this case, are bean seeds that are pla
The user services assistant (USA) is a novel reactive QoS agent that provides facilities for managing user to user QoS in Internet environments. By being reactive, it overcomes the problems associated with QoS management schemes that have been proposed to date, such as the mapping of the QoS parameters to end system parameters, and pre-determining the optimum way of degrading/upgrading the QoS. Ho
Popular Abstract in Swedish Framgångsrik strålbehandling av cancerpatienter kräver att man kan bestämma den absorberade dosen i patienten med stor noggrannhet. Bara några enstaka procents avvikelse i absorberad dos kan ha betydelse för det kliniska resultatet avseende både tumörutläkning och normalvävnadsreaktioner. För att beräkna den absorberade dosen i patienten används sofistikerade datorprogThe accuracy of dose calculations for various aspects of a treatment planning system (TPS) using an energy fluence beam modelling has been evaluated. The investigated TPS uses a beam model, which separates the energy fluence into a number of sources in the treatment head. The energy fluence components are transported towards the patient and, together with the scatter generated in the patient, yiel
BMP receptors determine the intensity of BMP signals via Smad1 C-terminal phosphorylations. Here we show that a finely controlled cell biological pathway terminates this activity. The duration of the activated pSmad1Cter signal was regulated by sequential Smad1 linker region phosphorylations at conserved MAPK and GSK3 sites required for its polyubiquitinylation and transport to the centrosome. Pro
