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Black-box policy optimization is a class of reinforcement learning algorithms that explores and updates the policies at the parameter level. This class of algorithms is widely applied in robotics with movement primitives or non-differentiable policies. Furthermore, these approaches are particularly relevant where exploration at the action level could cause actuator damage or other safety issues. H
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TLK1/TLK2) to chromatin assembly and maintenance of replication fork integrity. We show that TLK activ
This work presents the architecture of a prototype software system for image preprocessing and analysis designed to support the guidance of an auxiliary UAV camera. The study begins with an overview of typical UAV onboard elec-tronics, highlighting the electro-optical equipment, which includes a navigation camera and an auxiliary camera with a narrower field of view. Automatic image analysis from
Much scholarship has critiqued the fact that non-governmental organisations (NGOs), as a result of global neoliberalism and consequential state retreat, have become private service providers of children’s protection rights. But how can we explain the situation when neoliberal states also undergo autocratisation and take back service provision from NGOs, while at the same time preserving the privat
Background: Age-related immunosenescence, also known as ‘inflammageing’, may impact the elderly’s ability to mount immune responses against cancers and compromise the effectiveness of immune checkpoint inhibition (ICI). In this context, data on tonsillar cancer (TC), a subset of head and neck squamous cell cancer (HNSCC), are lacking. Aims/objectives: To compare the presence/distribution and featu
Creating thermally stable collagen mimetic peptides (CMPs) is a persistent challenge. Nature leverages covalent crosslinkings to stabilize collagen's signature triple helical tertiary structure and higher-order assemblies. Herein, crosslinkings between levodopa (Dopa) and lysine can covalently stabilize the triple helix in CMPs is demonstrated. Since alkaline conditions catalyze the oxidation of t
Computational analysis of large-scale metagenomics sequencing datasets provides valuable isolate-level taxonomic and functional insights from complex microbial communities. However, the ever-expanding ecosystem of metagenomics-specific methods and file formats makes designing scalable workflows and seamlessly exploring output data increasingly challenging. Although one-click bioinformatics pipelin
This article presents a Luhmann-inspired theory of conflictualization, that is, how objects, relations, and societies come to be defined by the logic of conflict. This article presents a Galtung- and Luhmann-inspired theory of conflictualization, that is, how objects, relations, and societies come to be defined by the logic of conflict. The article conceptualizes conflictualization as a threefold
Sensor degradation poses a significant challenge in autonomous driving. During heavy rainfall, interference from raindrops can adversely affect the quality of LiDAR point clouds, resulting in, for instance, inaccurate point measurements. This, in turn, can potentially lead to safety concerns if autonomous driving systems are not weather-aware, i.e., if they are unable to discern such changes. In t
Shared housing is a rather unusual phenomenon in Sweden. However, due to the decreasing availability of affordable housing and a large share of single-person households in urban areas, sharing is on the rise and new forms of shared housing have entered the market. By analysing how shared housing overlaps with existing patterns of socioeconomic segregation and by interviewing developers of diverse
Background: Despite the rapid pace of assistive robotics development, adoption of these has been limited. This raises questions such as: What contributes to this low uptake? What strategies could be employed to increase uptake? What guidance can be found in the literature to inform alternative approaches or directions for development?Objective: This critical narrative review sheds light on the dev
Advancing the use of air-sensitive polar organometallic Grignard and organolithium reagents under more environmentally benign conditions, here we report the addition of these reagents to a-b unsaturated ketones and aldehydes using the deep eutetic solvent (DES) choline chloride (ChCl): glycerol (Gly) (1:2), under air. Reactions occur at room temperature within seconds with excellent regioselective
Aim: To describe what is known about hip problems in individuals with developmental central hypotonia. Method: Searches were conducted in five databases to October 2023. Down syndrome was excluded from this analysis of less well-known genetic diagnoses. At least two reviewers independently screened titles, abstracts, read full-text articles, and extracted data. Results: Of 89 full-text articles, 7
In September 2024, I started creating a performance entitled Encruzilhada, based on my understanding of carrego colonial (colonial burden), a concept elaborated on by Brazilian pedagogue Luiz Rufino in his work Pedagogia das Encruzilhadas (Pedagogy of the Crossroads). Encruzilhada concentrates on the production of an ebó (offer, sacrifice) to Exu. The ebó, in this case, are bean seeds that are pla
In order to treat highly localized excitations in a solid a simple spherical model has been developed. The Coulomb potential from the nucleus at the site of the excitation is treated exactly, while the potentials from the surrounding sites are turned into pseudoion pontentials. Only the spherical average of these potentials is retained and separate self-consistent calculations for the ground state
Background and purpose: Pyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X-linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1-related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii) delineate the associated phenotype. Methods: In a natio
Allergic contact dermatitis is reported among individuals using continuous glucose monitoring systems and insulin pumps. The aim of this study was to describe contact allergy patterns for allergens in the Swedish baseline series and medical device-related allergens among users. Contact allergy to baseline series allergens and isobornyl acrylate was compared between diabetes patients and dermatitis
