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Background: More women in reproductive ages are entering occupations where exposure to whole body vibrations (WBV) is common (e.g. in transportation and construction). Previous studies based on self-assessed exposure suggest increased risks of adverse birth outcomes, but it is unclear at what exposure levels and if the current exposure guidelines are appropriate during pregnancy. Objectives: To in
Soil contamination is a widespread problem and actions need to be taken in order toprevent damage to the groundwater and the life around the contaminated sites. InSweden more than 80.000 sites are potentially contaminated, therefore there is ademand for accurate and efficient methods for site characterization and soilremediation. In the past, the preferred methodology for soil remediation involved
Dataharmonisering är en förutsättning för smarta städer, för ett mer effektivt informationsflöde i samhällsbyggnadsprocessen och för många andra tillämpningar i en stadsmiljö. Vid ett bästa tänkbart scenario kommer dataharmonisering att resultera i ett digitalt informationsflöde som inkluderar information från ett objekts hela livscykel, till exempel för byggnader, vägar och tunnlar. Alla aktörer Data harmonisation is a prerequisite for smart cities, for a more efficient information flow in the planning and building process and for many applications in the urban environment. Ideally, data harmonisation will result in a digital information flow that include information from the whole lifecycle of a feature, for example for buildings, roads and tunnels. All actors and applications involved i
Little is known about the long-term consequences of anorexia nervosa (AN) in terms of possible brain neuronal injury. We aimed at investigating whether women with adolescent-onset AN exhibit increased serum levels of neurofilament light chain protein (NfL), a biomarker for neuronal injury, compared with matched controls at 30-year follow-up. Blood samples were collected from 34 women with adolesce
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of the disease. Methods and Results We measured 112 baseline fasting metabolites of 3770 participants in the Malmö Diet and Cancer Study; these participants were fre
Aim: To investigate the antidiabetic efficacy of enzymatically stable Peptide YY (PYY) peptides from phylogenetically ancient fish. Materials and methods: N-terminally stabilized, PYY (1–36) sequences from Amia calva (bowfin), Oncorhynchus mykiss (trout), Petromyzon marinus (sea lamprey) and Scaphirhynchus albus (sturgeon), were synthesized, and both biological actions and antidiabetic therapeutic
Accelerated telomere shortening has been associated with several age-related diseases and/or decreased lifespan in humans. The Mediterranean diet (MedDiet) is considered to be 1 of the most recognized diets for disease prevention and healthy aging, partially due to its demonstrated anti-inflammatory and antioxidative properties which may impact on telomere length (TL). The aim of this meta-analysi
Objectives: To investigate the interaction effect of sex and apolipoprotein E (APOE) genotype on long-term cognitive and functional outcomes and survival in Alzheimer’s disease (AD). Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study in clinical practice involving 999 participants diagnosed with mild-to-moderate AD at the start of cholinesteras
INTRODUCTION: Exercise interventions have a strong evidence base for falls prevention. However, exercise can be challenging to implement and often has limited reach and poor adherence. Digital technology provides opportunities for both increased access to the intervention and support over time. Further knowledge needs to be gained regarding the effectiveness of completely self-managed digital exer
Background: Nine mRNA transcripts associated with acute cellular rejection (ACR) in previous microarray studies were ported to the clinically amenable NanoString nCounter platform. Here we report the diagnostic performance of the resulting blood test to exclude ACR in heart allograft recipients: HEARTBiT. Methods: Blood samples for transcriptomic profiling were collected during routine post-transp
In old mnemonic systems, like the Memory Palaces (Ricci) and the Memory Circles (Llull), the general purpose is to organize and preserve the images of memory over time. However, in contemporary discussions of memory taking place within the field of trauma studies (Leys, Laub, Feldman, Caruth, van der Kolk), the focus is on the forgotten, and on understanding why we do not remember traumatic events
Objective: The insulin responsive adiponutrin (PNPLA3 or ADPN) gene shows association with obesity and in vitro adipocyte lipolysis. This study aimed to replicate the association between PNPLA3 variants and obesity, and to investigate their effect on insulin resistance and beta-cell function. Methods: rs738409 (Met148Ile) and rs2072907 (C to G) were genotyped using TaqMan allelic discrimination as
The risk among asphalt workers of developing adverse health effects may increase due to their occupational exposure. One area of special concern arises when rubber granules are mixed into bitumen to enhance asphalt properties. This research characterizes and compares bitumen and rubber bitumen regarding the emissions of and workers' exposure to particulates, polycyclic aromatic hydrocarbons (PAHs)
Historical wage studies have never been able to truly or accurately address the changes in the working year. Real wages have almost always been based on the wages of unskilled and casual laborers, typically paid by the day. Their annual incomes are not clear or obvious – the income is directly dependent on how many days they work. Implicitly the literature has assumed that the number of days work
Background: C3 is highly expressed in human and rodent pancreatic islets, which secrete insulin to regulate blood glucose homeostasis. We have previously shown that cytosolic C3 protects pancreatic beta-cells from stress, by allowing cytoprotective autophagy, and that the same intracellular pool of C3 also protects beta-cells from cytokine-induced apoptosis. Methods: We now generated a beta-cell s
Background: Postoperative lymph node irradiation can affect shoulder morbidity in breast cancer patients, yet widely accepted dose-volume constraints for the shoulder joint are lacking. The SENOMAC trial randomized patients with breast cancer and 1–2 sentinel lymph node (SLN) macrometastases to axillary lymph node dissection (ALND) or SLN biopsy only. We aimed to analyze the association between th
The evacuation of hospitals in the event of fires and similar emergencies can be a difficult endeavor. Patients usually require assistance, with a considerable number of them being unable to evacuate by themselves due to medical conditions or due to the treatment they are receiving. Assistance is to be provided by the healthcare staff in the affected ward, which means that their level of preparedn
The purpose of this master´s thesis was to investigate the role and function of the annual reports of public libraries: for what purpose are they put together and how are they evaluated and utilised. The study presents different views on the structure and content of library annual reports. Focusing on a specific public library and its municipal administration, the authors identify and describe pro
Title Incentives in a Common Agency: An Experiment Author Roy Forsberg Seminar date 2007-01-31 Tutors Dr. Fredrik Andersson and PhD Tommy Andersson Course Master Thesis in Economics – 10 Swedish credits (15 ECTS) Purpose Analyze the make-or-buy decision from a microeconomic perspective by combining modern common agency theory with the theory of incentives and game theory. From this I hope to conve
Background: Acute thromboembolic occlusion of the superior mesenteric artery (SMA) is associated with high mortality. Recent advances in diagnostics and surgical techniques may affect outcome. Methods: Through the Swedish Vascular Registry (Swedvasc), 121 open and 42 endovascular revascularizations of the SMA at 28 hospitals during 1999 to 2006 were identified. Patient medical records were retriev
