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Centrum för handelsforskning vid Lunds universitet VERKSAMHETSBERÄTTELSE | 2024 2 VERKSAMHETSBERÄTTELSE CENTRUM FÖR HANDELSFORSKNING 2024 3 VERKSAMHETSBERÄTTELSE CENTRUM FÖR HANDELSFORSKNING 2024 Introduktion Centrum för handelsforskning - 2024 det sista kapitlet Detta är den 11:e årsrapporten från Centrum för handels- forskning vid Lunds universitet. Det är också den sista års- rapporten vi skriv
PURPOSE: The first interim analysis of the phase III, randomized, placebo-controlled TITAN study showed that apalutamide significantly improved overall survival (OS) and radiographic progression-free survival in patients with metastatic castration-sensitive prostate cancer (mCSPC) receiving ongoing androgen deprivation therapy (ADT). Herein, we report final efficacy and safety results after unblin
OBJECTIVE: In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 patients with DLB (age 45-93 years, 31% women). Positivity on β-amyloid (A+)
Background and aim: Vitamin K has been proposed to have a preventive effect against arterial calcification through activation of the vitamin K dependent proteins and potentially protect against progression of atherosclerosis. Our aim was to assess the association between vitamin K status and vascular health in a general elderly population. Methods and results: In a cross-sectional study, the vitam
Fluid biomarkers are revolutionizing the diagnosis and management of neurodegenerative diseases by enabling earlier diagnosis and disease monitoring. In particular, blood-based biomarkers have emerged as a minimally invasive and scalable alternative to cerebrospinal fluid analysis. Recent advances in blood-based tau biomarkers have shown high diagnostic accuracy for Alzheimer’s disease (AD). Other
One of the key ecological processes affected by climate change is plant carbon uptake. However, there is substantial uncertainty about how plant carbon uptake will respond to warming in mountain ecosystems, which are known for sharp temperature gradients and abrupt shifts in vegetation structure. Specifically, we lack an understanding of whether these response trajectories over time will be linear
Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat
Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loc
Accurate diagnosis of rare inherited anaemias is challenging, requiring a series of complex and expensive laboratory tests. Targeted next-generation-sequencing (NGS) has been used to investigate these disorders, but the selection of genes on individual panels has been narrow and the validation strategies used have fallen short of the standards required for clinical use. Clinical-grade validation o
The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelat
Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i
The Sardinian dhole (Cynotherium sardous) was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene. Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African hunting doThe Sardinian dhole (Cynotherium sardous)1 was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene.2-5 Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African huntin
The SCHOLAR-2 retrospective study highlighted poor overall survival (OS) with standard of care (SOC) regimens among patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) who failed a covalent Bruton tyrosine kinase inhibitor (BTKi). In the ZUMA-2 single-arm trial, brexucabtagene autoleucel (brexu-cel; autologous anti-CD19 CAR T-cell therapy) demonstrated high rates of durable response
INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB p
The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n
Projektkoordinator Kontaktinformation E-post: stefan [dot] olin [at] mgeo [dot] lu [dot] se Telefon: +46 46 222 38 30Organisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsStefan Olins profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Profilområdesmedlem LU pr
https://www.nateko.lu.se/sv/stefan-olin - 2026-10-14
Projektkoordinator Kontaktinformation E-post: stefan [dot] olin [at] mgeo [dot] lu [dot] se Telefon: +46 46 222 38 30Organisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsStefan Olins profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Profilområdesmedlem LU pr
https://www.mgeo.lu.se/stefan-olin - 2026-10-14
REPORT ON PROGRESS 2015 copenhagen business school pr in ci pl es fo r re sp on si bl e m an ag em en t e du ca ti on 2 This is the Copenhagen Business School’s (CBS) third Sharing Information on Pro- gress (SIP) report on the United Nations (UN) Principles for Responsible Manage- ment Education (PRME). It summarises CBS’ achievements and our ambition to become a leading business school in respons
https://www.ses.lu.se/sites/ses.lu.se/files/cbssustainability_report2015.pdf - 2026-10-15
VETENSKAP OCH BEPRÖVAD ERFARENHET TANDVÅRD VETENSKAP OCH BEPRÖVAD ERFARENHET VID SBU | 1 2 | STEN ANTTILA & SUSANNA AXELSSON VETENSKAP OCH BEPRÖVAD ERFARENHET TANDVÅRD ISBN 978-91-983575-8-5 © VBE-programmet och författarna Grafisk form Johan Laserna Tryckt av Media-Tryck, Lunds universitet, Lund 2019 Förord 9 NILS-ERIC SAHLIN Vad är vetenskap och vad är beprövad erfarenhet? Och vad betyder eviden
https://www.vbe.lu.se/sites/vbe.lu.se/files/vbe_tandvard_webb.pdf - 2026-10-15
