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Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. As an example, in post-mortem brai
Objective: To overview and summarise the Swedish National Guidelines on Urothelial Carcinoma 2024. Methods: A narrative review of the updated guidelines was performed, highlighting new treatment recommendations for advanced and metastasized disease. Results: Compared to the previous guideline version, the current update includes recommendations for standardised radiological reporting when urotheli
Pathogenic bacterial infections lead to bacterial resistance and biofilm formation, causing significant suffering and presenting an urgent issue to be addressed. Polymer materials have garnered considerable attention in the antibacterial field due to their functional moldability and molecular structure designability. These materials can achieve various antibacterial functions by regulating their m
In 2011 Eli Pariser coined the term ‘filter bubble’ and warned that online algorithm driven filters based on users’ click behaviour, would risk to reduce the diversity of public discourses and thereby deliberative democracy. Through the multidisciplinary and iterative Realist Synthesis method, the aim of the study has been to synthesise empirically based understanding of how online algorithm drive
This thesis applies a Foucauldian genealogy to examine the power relations in global univer-sity rankings, by analysing three strategic reports from Lund University. The strategic reports are from 1995-2000, 2012-2016, and 2017-2026. The theory applied is Foucault’s pow-er/knowledge theory. The research question that guides this thesis is What signs of adaptation to rankings can be identified in t
Människorna i dagens samhälle vill kunna ta del av så mycket information som möjligt. Positiva förändringar i ett samhälle sker endast om information kring negativa förhållanden avslöjas. I arbetslivet är det arbetstagare som har närmast till information om missförhållanden. Vilket gör att visselblåsare har en viktig kontrollfunktion på svenska arbetsplatser. Aktuella händelser, internationella rePeople in today's society always want as much information as possible. Positive changes in a society can only happen if information about misconduct is revealed. The employees are the ones closest to information about misconduct in the workplace. Therefore whistleblowers are important sources of information that eventually will lead to improvements and better control of Swedish workplaces. Cur
Den 1 januari 2009 trädde de svenska ränteavdragbegränsningsreglerna i 24 kapitlet inkomstskattelagen (1999:1229) i kraft. Syftet med reglerna var att hindra s.k. räntesnurror där bolag utfärdar koncerninterna lån för att flytta vinster till lågbeskattade länder genom ränteavdrag huvudsakligen för att er- hålla en väsentlig skatteförmån. Ränteavdragbegränsningsreglerna har därefter ändrats vid tvåOn January 1, 2009, the Swedish interest deduction restriction rules in Chapter 24 of the Income Tax Act (1999: 1229) entered into force. The purpose of the rules was to prevent transfer mispricing “räntesnurra” where companies issue intra-group loans to transfer profits to low-taxed countries through interest deductions mainly to obtain a significant tax benefit. The interest de- duction restrict
Digitaliseringen har revolutionerat våra samhällen. Hur vi kommunicerar och interagerar med varandra och hur vi handlar produkter och tjänster har över de senaste åren varit föremål för drastiska förändringar. Bakom dessa förändringar står ett fåtal digitala jättar. Trots att förändringarna har ökat konsumentvälfärden och i regel varit positiva, har farhågor lyfts. Detta har inte minst uppmärksamm
The High Luminosity Large Hadron Collider (HL-LHC) at CERN, an improvement to the LHC, scheduled to be operating in 2027, will further the potential for scientific breakthroughs in High Energy Physics. The project’s demand in computational resources, however, is predicted to exceed what will be available then. Thus, efficiency optimization of Monte Carlo simulations of the collisions that occur in
Traditional security studies focuses primarily on physical threats to the state. By contrast, the ontological security framework argues that individuals feel secure when they are able to maintain a communal narrative. Such a framework lends itself to an analysis of the impact of identity continuity on security. This thesis uses the ontological framework to understand the security issues that arise
Bostadsmarknaden har under en längre tid kantats av ett antal problem både på ägande- och hyresmarknaden. Majoriteten av landets kommuner rapporterar en rådande bostadsbrist och effektivitetsförlusten till följd av efterfrågeöverskottet beräknas till 10 miljarder kronor per år. Identifierade problem på bostadsmarknaden är avsaknaden av fungerande flyttkedjor, långa bostadsköer, höga bostadspriser The Swedish housing market has been pressured for a long time with a majority of Swedish municipalities reporting housing shortages. The efficiency loss due to unmet demand is estimated at 10 billion SEK annually. Identified obstacles on the housing market are lack of functioning vacancy chains, long housing queues, high prices and constraining legislation. In 2009, new legislation was introduced
The right to deduct input value added tax (“VAT”) depends on a direct and immediate link to a taxable persons taxable activities. The disposal of shares is either out of scope of VAT, since it is not considered an economic activity, or exempt from VAT. Consequently there is, in general, no right to deduct input VAT for costs relating to such a disposal. However, the Court of Justice of the Europea
In July 2013 Croatia has become the latest member state to join the European Union. Access to this single European area, in particular, to economically well-developed countries with a more robust labor market and a higher standard of living than Croatia resulted in intensification of emigration from Croatia. This has particularly affected young, well-educated Croats; ambitious, unsatisfied with th
Background: Ehlers-Danlos Syndrome (EDS) is a hereditary disease that affects the connective tissue of the body. Common symptoms include stretchy and frail skin, hypermobility, joint pain and chronic fatigue, although the disease is associated with many more symptoms. Because of this, the disease often remains un- or misdiagnosed. The interactions between patients with EDS and healthcare professio
