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Sertindole is an antipsychotic drug with affinity for dopamine D, serotonin 5-HT2A and 5-HT2C, and alpha(1)-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low cloparnine D-2 occupancy level. The active substance has a long half-life. Oral administration
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Popular Abstract in Swedish Sedan människan lyckades skapa eld har förbränning utgjort den viktigaste energikällan i mänsklighetens långa historia, viket den ser ut att fortsätta vara det inom en överskådlig framtid. I dagsläget kommer mer än 90% av vår energi från förbränningsprocesser. Dock uppstår en rad problem kring förbränning, såsom föroreningar och möjligheten till använda sig av förnyelseNowadays, more than 90% of our energy comes from combustion processes. Hence, it is very important to perform combustion research to reduce emissions, improve efficiency, find clean and renewable fuels, strengthen safety, etc. The complexity of combustion processes asks for advanced diagnostic tools, among which the laser spectroscopy has been proved to be a powerful one. This thesis is about the
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Popular Abstract in Swedish Tillväxtfaktorer påverkar signaler mellan celler i hjärnan Människors hjärnor innehåller flera miljarder hjärnceller, vilka är förutsättningen för vårt beteende, våra känslor och våra tankar. Hjärncellerna bildar kontakter, synapser, med varandra. Genom dessa överförs signaler från en cell till en annan. Varje cell kontaktar en mängd andra celler, både sådana med liknanThe neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. Such plasticity is believed to be a cellular correlate for important processes like learning, but also for diseases, for
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Popular Abstract in Swedish Syftet med föreliggande arbete har varit att undersöka statusen på nygjort glasmåleri från 1851-1955. Utgångspunkten har varit att detta glasmåleri oftast inte förekommer i konstens allmänna historia, trots att välkända konstnärer faktiskt gjort glasmåleri. Ett viktigt metodiskt grepp har varit att undersöka statusfrågan utifrån uppfattningar om glasmåleriets mediespeci
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Popular Abstract in Swedish Vi går mot ett mer och mer energikrävande samhälle. För att klara ett ökande behov av energi med de begränsande naturresurser som finns på jorden, har ett forskningsprojekt, som denna avhandling är en del av, som mål att utveckla artificiell fotosyntes. Den naturliga fotosyntesen använder sig av solljus för att omvandla koldioxid och vatten till energirika produkter såsThe work in thesis aims for artificial photosyntesis, which could and will mimic natural photosynthesis, the process that uses light to create energy rich compounds from H2O and CO2. Water is oxidized in Photosystem II (PSII) by the Water Oxidizing Complex (WOC), which is a catalytic site on the lumenal side of the thylakoid membrane. The chlorophyll complex P680 absorbs light and electrons are tr
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In the world of cryptography, stream ciphers are known as primitives used to ensure privacy over a communication channel. One common way to build a stream cipher is to use a keystream generator to produce a pseudo-random sequence of symbols. In such algorithms, the ciphertext is the sum of the keystream and the plaintext, resembling the one-time pad principal. Although the idea behind stream ciphe
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Modelling the distribution of migratory species has rarely been extended beyond breeding and wintering ranges despite many species showing much more complex movement patterns with multiple stopovers. We aimed to create a temporally explicit species distribution model describing the full annual distribution cycle, and use it to model the complex seasonal shifts in distribution of the common cuckoo
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Doctoral education in medicine, engineering, technology and science (METS) is in many ways different from doctoral education in the humanities or social sciences. In the METS disciplines, typically, students and supervisors work and publish together within the supervisors’ research projects. The projects are usually financed by the supervisors’ research grants and their success, in terms of high q
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The installation is based on two elements, a re-used tape recorder and a pair of aged wooden planks. The planks are mounted to form a table on which the tape recorder is placed. The sound from the tape recorder is based on field recordings from the area around the municipality Taivalkoski in Northeastern Finland. The tape recorder has formerly been used at The Department of Ethnology at Lund Univ
