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Reading a glycocode - mechanism and function of galectin-glycan interactions

Popular Abstract in Swedish Våra celler är täckta av kolhydrater (socker) som är kopplade till proteiner och lipider på cellens yta. Olika celler presenterar olika socker, och en och samma cell kan dessutom ändra sitt sockeruttryck beroende på hur den mår och vad den vill utföra, till exempel dela sig eller dö, en effekt man ofta ser i cancer. På så sätt fungerar sockerstrukturerna som en kod som There is an intensive interest in characterising the structure and function of galectins, which is not surprising given their many important cellular functions and strong implications in human disease. Understanding the mechanisms involved in galectin functions will help to find selective and novel strategies for disease treatment and diagnosis. A key to this lies in their carbohydrate binding spe

Local steroid injection for moderately severe idiopathic carpal tunnel syndrome: Protocol of a randomized double-blind placebo-controlled trial (NCT 00806871)

Background: Patients with idiopathic carpal tunnel syndrome (CTS) are commonly treated with steroid injection into or proximal to the carpal tunnel. However, evidence for its efficacy beyond one month has not been established in randomized placebo-controlled trials. The primary aim of this randomized trial is to assess the efficacy of steroid injection into the carpal tunnel in relieving symptoms

Inter-System Handovers in Heterogeneous Wireless Systems

To better utilize existing wireless systems, they can be combined together to interact and thereby provide better balanced capacity. They can further profit from this by getting their ongoing connection moved from the current system to another. The main issues are to make this move without losing the ongoing connection and to make it seamless, i.e., without the user noticing it. This action of mov

Tubular regeneration: when can the kidney regenerate from injury and what turns failure into success?

Background: The most common intrarenal cause for acute kidney injury/renal failure is tubular damage. The kidney tubules are arranged as compartments of cellular mosaics to perform their functions, and at rest almost a fifth of the human ATP consumption is allotted to the reabsorption of substances from the filtrate, rendering especially the proximal tubules highly sensitive to oxygen and/or nutri

Haemophilus influenzae adhesins and the innate immune response

Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause diseases such as meningitis and epiglottitis. Non-encapsulated H. influenzae referred to as nontypeabl

Axl RTK and microRNAs in urogenital cancers

This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs in a publically available cohort of ccRCC, which were measured in a cohort of 198 RCC tumors. Impo

Molecular Mechanisms in Hematopoietic Stem Cell Aging

Popular Abstract in Swedish Blodet är sammansatt av många olika typer av mogna celler som är ansvariga för specialiserade roller inom blodsystemet. Röda blodceller transporterar syre till kroppens celler, vita blodceller förser oss med försvar mot mikroorganismer och blodplättar ser till att stoppa blödningar. Nybildning av blodceller behövs kontinuerligt eftersom vissa celler lever bara i några dThe blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge

"Adoption - om rätten till sitt ursprung"

Sammanfattning Uppsatsen behandlar det adopterade barnets rätt till kännedom om sitt ursprung. Frågan har diskuterats vid flertalet tillfällen och är nu aktuell på nytt, då den uppmärksammas i utredningen SOU 2009:61 – Modernare adoptionsregler. I utredningen föreslås en lagstadgad informationsskyldighet för adoptivföräldrar att informera barnet om dess ursprung. Denna bestämmelse skall sakna sankSummary This Graduate Thesis examines the adopted child´s right to knowledge of his or her origin. The biological parentage has been a subject of discussion throughout the history of adoption. In accordance with SOU 2009:61, the Committee has proposed a provision to be introduced requiring a person who has an adopted child, to inform the child of his or her biological origin. The provision is not

Kan religiösa manifestationer påverka vår könsjämlikhet?

Religionsfrihet är en grundläggande mänsklig rättighet. Artikel 9 i Europakonventionen reglerar religionsfriheten och dess begränsningar. Konventionen är inkorporerad i svensk lagstiftning och ska således tillämpas i Sverige. Med anledning av det så kallade handskakningsmålet ställs religionsfriheten i förhållande till arbetet mot ett könsjämlikt arbetsliv. Frågan väcks och diskuteras huruvida relFreedom of religion is a fundamental human right. Article 9 of the European Convention regulates religious freedom and its limits. The Convention is incorporated in Swedish law and has to be applied in Sweden. On account of the so-called handshake-case, the freedom of religion is put in relation to work towards a gender-balanced working life. The question is raised and discussed whether freedom of

Organisationsstrukturens roll vid proaktiv krishantering

Problem: Today's changing environment gives rise to rapid sequence of events and rapid information dissemination. More attention is given to crisis and how organizations should manage them. Today there is much literature and many approaches to illustrate how an organization can optimize their crisis management, but yet crisis continues to generate problems for organizations. We believe that on

ReDesign of RollNap - a technical and aesthetical development of a napkin dispenser

This report is part of a Master Thesis in Mechanical Engineering with Industrial Design at the Faculty of Engineering, Lund University. The Master Thesis was performed at SCA, a global paper company that operates within the segments personal care, tissue, packaging, publication papers and solid-wood products. SCA sells products in more than 100 countries. Tork is the global brand name for SCA prod

3D-glass keypad for future mobile phones of Sony Ericsson Mobile Communications AB

Abstract The competition regarding market shares in the mobile handset industry is tough. Today the mobile phone is more and more becoming a personal accessory and trends in shape, color and material are changing rapidly. The keypad is one of a phone’s many components which the end user gets in touch with first. It is used to activate the phone, and it is what the user feels and looks at initially

Analys av vävmaskin

Texo AB is a private company which is specialized on development of looms for production of paper machine clothing. The company is located to Älmhult in southern Sweden and today employs about 90 persons. The calculation job treats 4 independent tasks, of which 3 is dealing with the same type of machine which is almost at the prototype state at the moment. The new machine TC 74 is a cam controlled

Small and Distributed Wind Energy in Argentina: Barriers and Development Strategies

This study aims to identify barriers to small wind energy in Argentina, and provide recommendations for Argentine stakeholders and policymakers for promoting the development of small wind. Argentina faces a serious energy challenge with its high dependence on fossil fuels (especially natural gas) in the face of rising global prices and decreasing reserves, challenges in domestic production and exp

Carrots, Sticks, Tigers and Wheels: A Case Study of Municipal Governance for Energy Efficiency in New Buildings in the Öresund Region

The Öresund Region, comprising areas of Sweden and Denmark, is involved in a process of sustainable urban transformation. The region has high ambitions in terms of carbon emissions reduction and has set itself steep targets to meet over the next 15-20 years. The energy consumption of buildings accounts for a significant proportion of carbon emissions. With the urban areas of the Öresund Region exp