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Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic cell proliferation and chronic inflammation in an HCD-consuming human-relevant pig model. We observed elevated colonic mucosal interleukin-6 (IL-6) ex

Background: Chronic non-healing wounds present a substantial economic burden to healthcare system; significant reductions in quality of life for those affected, and precede often serious events such as limp amputations or even premature deaths. This burden is also likely to increase with a larger proportion of elderly and increasing prevalence of life-style diseases such as obesity and diabetes. R

U–Pb baddeleyite ages demonstrate the presence of three dyke generations within the NW-trending Pará de Minas swarm (São Francisco craton, South America), dated at ca. 1795 Ma (1798 ± 4, 1791 ± 7 and 1793 ± 18 Ma), ca. 1710 Ma (1702 ± 13 and 1717 ± 11 Ma) and 766 ± 36 Ma. These ages have implications for the São Francisco-Congo (SF-Congo) craton within the Rodinia and Columbia supercontinent confi

Objective. To study the clinical and laboratory characteristics of patients with biopsy-proven giant cell arteritis (GCA) with visual complications, and to evaluate the incidence rate of visual complications in GCA compared to the background population. Methods. Data from 840 patients with GCA in the county of Skane, Sweden, diagnosed between 1997 and 2010, were used for this analysis. Cases with

In aqueous systems with immobilized macromolecules, including biological tissue, the longitudinal spin relaxation of water protons is primarily induced by exchange-mediated orientational randomization (EMOR) of intra- and intermolecular magnetic dipole-dipole couplings. Starting from the stochastic Liouville equation, we have developed a non-perturbative theory that can describe relaxation by the

BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a dia

Popular Abstract in Swedish Giftiga alger - kan man äta sånt?! En sammanfattning på svenska Varje sommar varna's vi för giftiga algblomningar i media. Rapporterna brukar ofta handla om havet men många insjöar, speciellt i Skåne, drabba's också av massförekomst av alger. Det är framför allt cyanobakterier, eller blå-gröna alger som de kallade's innan, som blir så många att de helt dominerar algsaMass development of cyanobacteria (blue-green algae) is common in many lakes and coastal waters worldwide as a result of an increased nutrient loading. These blooms of cyanobacteria are undesirable for several reasons; thick mats of algae and unpleasant odour reduces the recreational values, bad taste reduces the quality of drinking water and the potent toxins produced by some species of cyanobact

Popular Abstract in Swedish Arbetet med denna avhandling har handlat om hormon-känsligt lipas (HKL) och dess roll i β-cellerna, som producerar insulin och finns i bukspottskörteln. För att senare kunna beskriva vad vi har kommit fram till och vad det kan innebära, kommer jag först att kort beskriva HKL och sjukdomen diabetes. Hormon-känsligt lipas Hormon-känsligt lipas (HKL) är ett enzym, som fiHormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization. It is acutely regulated by extracellular signals via reversible phosphorylation. In the recent past, the focus of type 2 diabetes research has moved towards the lipid component. Lipids interfere with glucose homeostasis in a multitude of ways; they can decrease insulin sensitivity of tissues and cause β-cell dysfunction. Co