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Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation
Positive and negative aspects of colostomy irrigation : a patient and WOC nurse perspective
PURPOSE: Colostomy irrigation (CI) is an effective method to achieve fecal continence in selected persons with a colostomy. The primary aims of the study were to find out to what extent the WOC nurses used CI in their practice and what kind of information the WOC nurses gave patients if they provided explanations and potential solutions when irrigation was not successful in preserving continence.
Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases
Distrust in the end-of-life care provided to a parent and long-term negative outcomes among bereaved adolescents : A population-based survey study
Purpose Previous research shows that the death of a parent places children at risk for a number of negative outcomes. The role of trust in health care at the end of life has been acknowledged as crucial for patients and adult family members. However, the consequences of children’s distrust in the care provided to their parents remain unknown. Therefore, we investigated the negative long-term outco
Do Swedish Multinationals Pay Less in Taxes than Domestic Firms?
In recent years, there has been growing concern that multinational enterprises (MNEs) engage in strategic tax planning in order to shift profits to low-tax jurisdictions. This common perception is generally confirmed by empirical evidence, which is foremost provided for countries with high corporate taxes and relatively complex tax systems. We investigate whether multinational firms in a country w
Proteomic analysis of phytophthora infestans reveals the importance of cell wall proteins in pathogenicity
The oomycete Phytophthora infestans is the most harmful pathogen of potato. It causes the disease late blight, which generates increased yearly costs of up to one billion euro in the EU alone and is difficult to control. We have performed a large-scale quantitative proteomics study of six P. infestans life stages with the aim to identify proteins that change in abundance during development, with a
The mitochondrial outer membrane AAA ATPase AtOM66 affects cell death and pathogen resistance in Arabidopsis thaliana
One of the most stress-responsive genes encoding a mitochondrial protein in Arabidopsis (At3g50930) has been annotated as AtBCS1 (cytochrome bc1 synthase 1), but was previously functionally uncharacterised. Here, we show that the protein encoded by At3g50930 is present as a homo-multimeric protein complex on the outer mitochondrial membrane and lacks the BCS1 domain present in yeast and mammalian
Fate of riverine iron over estuarine salinity gradients
Floder och åar är viktiga källor för järn och andra näringsämnen till Östersjön. De senaste decennierna har järnkoncentrationen i svenska och finska åar ökat kraftigt, vilket skulle kunna leda till en ökad transport av järn till Östersjön. Vilken effekt detta kan ha för Östersjön beror på vad som händer med järnet när det möter det salta vattnet i Östersjön. Järn transporteras huvudsakligen i form
Innovative assistive technologies in dementia care between hopes and disillusion. A critical reflection based on the Tech@home experience in Sweden
Global dementia rates will more than triple by 2050, thus challengingsociety. Due to ageing in place policies, informal caregiving is increasing asmore people with dementia continue living at home despite significant careneeds. While most caregivers are willing to act as such, they are notalways adequately supported, thus reporting a high burden, worse mentaland physical health. Innovative Assisti
Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail
Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid bilayers. Peripheral neuropathies, such as Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas syndrome (DSS), are incurable demyelinating conditions that result in pain, decrea
Fetal hyperglycemia changes human preadipocyte function in adult life
Is a hollow centralizer necessary when using a polished, tapered, cemented femoral stem? : A randomized, controlled RSA study of 60 hips with 10 years of follow-up
Background and purpose — A tapered, polished and collarless stem is normally equipped with a hollow centralizer to prevent the stem from becoming end-bearing in the cement as the stem subsides. In a randomized clinical trial, we evaluated such a stem (MS-30), which was initially introduced with a solid centralizer but was later recommended to be fitted with a hollow centralizer. We hypothesized th
Multiple paper monies in Sweden, 1789-1903: Substitution or complementarity?
In relation to other European economies, Sweden experienced both an early anda widespread circulation of officially sanctioned paper monies of various origins. In 1661, the short-lived Stockholm Banco started to issue copper notes which came to circulate above par value. A few years later, the Parliament opened its own bank, Rikets Ständers Bank, literally meaning the Parliament’s Bank, now known
Spatiotemporal pattern of Wnt-canonical pathway in dorsal telencephalic organoids.
In the last decade, organoid technology has filled the gap generated by the poor accessibility and unique features of the human brain. Organoids present several advantages in comparison with two-dimensional culturing, since they recapitulate cytoarchitecture in space and functionality of the tissue. Therefore, they mimic the unique features of human brain better than animal models. Although signif
A Joint Desalination and Power Plants for Water and Development: A Case study of the Sinai-Gaza
Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza (enclosed area) is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasi
IgG Fc sialylation is regulated during the germinal center reaction upon immunization with different adjuvants
Towards a Gender-Aware understanding of innovation : A three-dimensional route
Identification of polymorphisms in Apolipoprotein M gene and their relationship with risk of recurrent venous thromboembolism
Antibodies against Phosphorylcholine among New Guineans Compared to Swedes : An Aspect of the Hygiene/Missing Old Friends Hypothesis
Background: We here study antibodies against phosphorylcholine (anti-PC) which we reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and autoimmune conditions. In previous studies, we determined that this inverse association is more pronounced at low levels with high risk and at high levels, with decreased risk. We compare individuals from Kitava, New Guinea (w
