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The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined. We performed an investigation of the expression of MYC protein in a cohort of 251 MCL patients complemented by analyses of structural aberrations and mRNA, in a sub-cohort of patients. Fourteen percent
The COVID-19 crisis intensified decade-long debates on the interaction between intellectual property rights (IPRs), competition law and access to affordable life-saving treatments and vaccines. Compulsory licensing of patented medicines is a tried-and-tested method to expand access, particularly in a situation of “national emergency or other circumstances of extreme urgency” within the meaning of
Biofuel production in the world has grown exponentially, stimulated by public policies, in countries of the North as well as of the South, and has been seen as one of the main drivers behind the recent food price hike. Thus conflicts over land need to be factored in when biofuels are assessed. Nowhere in the world is biofuel production seen to be more successful – economically, ecologically – than
This paper evaluates the history and cycling accessibility of Nova, a shopping centre established in Lund, Sweden, in 2002. The current situation was also analysed through observation and a literature review. Moreover, the study conducted a closer analysis of the history and role of the municipality based on further literature study and interviews with officials. The conclusion of the analysis indThis paper evaluates the history and cycling accessibility of Nova, a shopping centre established in Lund, Sweden, in 2002. The current situation was also analysed through observation and a literature review. Moreover, the study conducted a closer analysis of the history and role of the municipality based on further literature study and interviews with officials. The conclusion of the analysis ind
The purpose of this study was to develop a method to simulate breathing motion induced interplay effects for volumetric modulated arc therapy (VMAT), to verify the proposed method with measurements, and to use the method to investigate how interplay effects vary with different patient- and machine specific parameters. VMAT treatment plans were created on a virtual phantom in a treatment planning s
Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. Th
Medical doctors and nutritional specialists recommend to eat healthy foods including fruits and vegetables. Cosmetic experts also recommend to use cosmetic products obtained from natural products. The reason behind this is that natural products from plants contain chemical compounds which can promote health and protect our bodies from several diseases. These chemical compounds are called bioactiveBioactive compounds found in plants have been of interest to man since ancient times. These compounds have the ability to modulate the metabolic processes in our bodies, which suggests that they may promote better health. Bioactive compounds vary in their chemical structure, polarity, stability and biological activity. This diversity makes the study of bioactive compounds challenging from the pers
Background: After neoadjuvant chemotherapy (NAC), about 20% of pts with muscle-invasive UC are found to have advanced pT-stage or lymph node involvement and 5-year overall survival (OS) of them is < 30%. Tumor samples from these pts may provide information about chemotherapy resistance, and may predict for the activity of new drugs given postoperatively. Alterations of FGFR3 gene represent a thera
This thesis is based on work done by the author on the development of plasma-based electron accelerators driven by ultra-intense laser pulses and dense electron bunches. Plasma based accelerators have several benefits, such as accelerating fields around 1000 times stronger than in “conventional” radio-frequency accelerators, which can allow for shrinking the overall footprint of the accelerator. T
In this thesis, I critically explore the ways in which people consume extraordinary experiences and what this can tell us about contemporary society. My findings question the idea that extraordinary experiences are an escape from the demands of everyday life. I show instead that social (especially neoliberal) discourses discipline endurance runners and shape the ways in which they understand and a
Socio-economic shocks, technogenic catastrophes, and armed conflicts often have drastic impacts on local and regional food security through disruption of agricultural production and food trade, reduced investments, and deterioration of land and infrastructure. Recently, more research has focused on the effects of armed conflict on land systems, but still little is known about the processes and outSocio-economic shocks, technogenic catastrophes, and armed conflicts often have drastic impacts on local and regional food security through disruption of agricultural production and food trade, reduced investments, and deterioration of land and infrastructure. Recently, more research has focused on the effects of armed conflict on land systems, but still little is known about the processes and out
This study investigates acoustic and articulatory correlates of South Swedish word accents (Accent 1 vs. 2) – a tonal distinction traditionally associated with F0 timing. The study is motivated by previous findings on (i) the acoustic complexity of tonal prosody and (ii) tonal-articulatory interplay in other languages. Acoustic and articulatory (EMA) data from two controlled experiments are reportThis study investigates acoustic and articulatory correlates of South Swedish word accents (Accent 1 vs. 2) — a tonal distinction traditionally associated with F0 timing. The study is motivated by previous findings on (i) the acoustic complexity of tonal prosody and (ii) tonal-articulatory interplay in other languages.Acoustic and articulatory (EMA) data from two controlled experiments are reporte
Background: Sex workers have high incidences of HIV and other sexually transmitted diseases. Although, interventions targeting sex workers have shown to be effective, evidence on which strategies are most cost-effective is limited. This study aims to systematically review evidence on the cost-effectiveness of sexual health interventions for sex workers on a global level. It also evaluates the qual
Background. Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.Methods. SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, sa
This chapter situates John Rawls’ just savings principle in a discussion about how much a nation-state should save. The main question addressed is whether this principle is a viable alternative to the dominant utilitarian theory of optimal growth. Rawls certainly gives savings a different aim (i.e., to create and maintain just institutions) and introduces additional permissibility conditions on rThis chapter situates John Rawls’ just savings principle in a discussion about how much a nation-state should save. The main question addressed is whether this principle is a viable alternative to the dominant utilitarian theory of optimal growth. Rawls certainly gives savings a different aim (i.e., to create and maintain just institutions) and introduces additional permissibility conditions on re
Third-party generative AI services are increasingly embedded in organisational work, yet their emissions-related information is difficult for user organisations to access, interpret and govern. Scope 3-related reporting therefore raises an emerging information systems problem: how organisations can make supplier-dependent, uncertain and technically opaque emissions information traceable and usable
Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease Perspective https://doi.org/10.1038/s41591-019-0507-2 1John van Geest Centre for Brain Repair, Department of Clinical Neurosciences and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. 2John van Geest Centre for Brain Repair, Cambridge University, Cambridge, UK. 3A full list of members a
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/designing_stem-cell-based.pdf - 2026-07-19
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain Wen Lia, Elisabet Englundb, Håkan Widnerc, Bengt Mattssond, Danielle van Westene, Jimmy Lätte, Stig Rehncronaf, Patrik Brunding, Ander
https://www.wnc.lu.se/sites/wnc.lu.se/files/6544.full_.pdf - 2026-07-19
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain Wen Lia, Elisabet Englundb, Håkan Widnerc, Bengt Mattssond, Danielle van Westene, Jimmy Lätte, Stig Rehncronaf, Patrik Brunding, Ander
https://www.wnc.lu.se/sites/wnc.lu.se/files/pnas-2016-li-1605245113.pdf - 2026-07-19
Lund Psychological Reports Editor: Magnus Lindgren ISSN 1404-8035 Lund Psychological Reports Volume 19, No. 1, 2019 The SOL project: Attrition report Evaluating respondent attrition in a 10-year follow up of the SOL project “Deliberate self-harm, emotion regulation and interpersonal relations in youth.” SOL-research group: Daiva Daukantaitė Lars-Gunnar Lundh Margit Wångby-Lundh Benjamin Claréus Jo
https://www.psy.lu.se/sites/psy.lu.se/files/lpr_1901.pdf - 2026-07-19
