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The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined. We performed an investigation of the expression of MYC protein in a cohort of 251 MCL patients complemented by analyses of structural aberrations and mRNA, in a sub-cohort of patients. Fourteen percent
The COVID-19 crisis intensified decade-long debates on the interaction between intellectual property rights (IPRs), competition law and access to affordable life-saving treatments and vaccines. Compulsory licensing of patented medicines is a tried-and-tested method to expand access, particularly in a situation of “national emergency or other circumstances of extreme urgency” within the meaning of
Biofuel production in the world has grown exponentially, stimulated by public policies, in countries of the North as well as of the South, and has been seen as one of the main drivers behind the recent food price hike. Thus conflicts over land need to be factored in when biofuels are assessed. Nowhere in the world is biofuel production seen to be more successful – economically, ecologically – than
This paper evaluates the history and cycling accessibility of Nova, a shopping centre established in Lund, Sweden, in 2002. The current situation was also analysed through observation and a literature review. Moreover, the study conducted a closer analysis of the history and role of the municipality based on further literature study and interviews with officials. The conclusion of the analysis indThis paper evaluates the history and cycling accessibility of Nova, a shopping centre established in Lund, Sweden, in 2002. The current situation was also analysed through observation and a literature review. Moreover, the study conducted a closer analysis of the history and role of the municipality based on further literature study and interviews with officials. The conclusion of the analysis ind
The utilisation of biomass instead of fossil resources is an important alternative for the transition into a sustainable society. Biomass, owing to its primary constituents—cellulose, hemicelluloses and lignin—has the potential to replace many products that are produced from fossil resources today, including plastics, textile fibres and fuels. To fully exploit this potential, all of the componentsThe utilisation of biomass instead of fossil resources is an important alternative for the transition into a sustainable society. Biomass, owing to its primary constituents—cellulose, hemicelluloses and lignin—has the potential to replace many products that are produced from fossil resources today, including plastics, textile fibres and fuels. To fully exploit this potential, all of the components
The purpose of this study was to develop a method to simulate breathing motion induced interplay effects for volumetric modulated arc therapy (VMAT), to verify the proposed method with measurements, and to use the method to investigate how interplay effects vary with different patient- and machine specific parameters. VMAT treatment plans were created on a virtual phantom in a treatment planning s
Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. Th
Background: After neoadjuvant chemotherapy (NAC), about 20% of pts with muscle-invasive UC are found to have advanced pT-stage or lymph node involvement and 5-year overall survival (OS) of them is < 30%. Tumor samples from these pts may provide information about chemotherapy resistance, and may predict for the activity of new drugs given postoperatively. Alterations of FGFR3 gene represent a thera
This thesis is based on work done by the author on the development of plasma-based electron accelerators driven by ultra-intense laser pulses and dense electron bunches. Plasma based accelerators have several benefits, such as accelerating fields around 1000 times stronger than in “conventional” radio-frequency accelerators, which can allow for shrinking the overall footprint of the accelerator. T
In this thesis, I critically explore the ways in which people consume extraordinary experiences and what this can tell us about contemporary society. My findings question the idea that extraordinary experiences are an escape from the demands of everyday life. I show instead that social (especially neoliberal) discourses discipline endurance runners and shape the ways in which they understand and a
Socio-economic shocks, technogenic catastrophes, and armed conflicts often have drastic impacts on local and regional food security through disruption of agricultural production and food trade, reduced investments, and deterioration of land and infrastructure. Recently, more research has focused on the effects of armed conflict on land systems, but still little is known about the processes and outSocio-economic shocks, technogenic catastrophes, and armed conflicts often have drastic impacts on local and regional food security through disruption of agricultural production and food trade, reduced investments, and deterioration of land and infrastructure. Recently, more research has focused on the effects of armed conflict on land systems, but still little is known about the processes and out
This study investigates acoustic and articulatory correlates of South Swedish word accents (Accent 1 vs. 2) – a tonal distinction traditionally associated with F0 timing. The study is motivated by previous findings on (i) the acoustic complexity of tonal prosody and (ii) tonal-articulatory interplay in other languages. Acoustic and articulatory (EMA) data from two controlled experiments are reportThis study investigates acoustic and articulatory correlates of South Swedish word accents (Accent 1 vs. 2) — a tonal distinction traditionally associated with F0 timing. The study is motivated by previous findings on (i) the acoustic complexity of tonal prosody and (ii) tonal-articulatory interplay in other languages.Acoustic and articulatory (EMA) data from two controlled experiments are reporte
BACKGROUND: Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis.METHODS: Forty-two consecutive pSS patients and 35 age-matched aAltered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren’s syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis.
Background: Sex workers have high incidences of HIV and other sexually transmitted diseases. Although, interventions targeting sex workers have shown to be effective, evidence on which strategies are most cost-effective is limited. This study aims to systematically review evidence on the cost-effectiveness of sexual health interventions for sex workers on a global level. It also evaluates the qual
Background. Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.Methods. SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, sa
This chapter situates John Rawls’ just savings principle in a discussion about how much a nation-state should save. The main question addressed is whether this principle is a viable alternative to the dominant utilitarian theory of optimal growth. Rawls certainly gives savings a different aim (i.e., to create and maintain just institutions) and introduces additional permissibility conditions on rThis chapter situates John Rawls’ just savings principle in a discussion about how much a nation-state should save. The main question addressed is whether this principle is a viable alternative to the dominant utilitarian theory of optimal growth. Rawls certainly gives savings a different aim (i.e., to create and maintain just institutions) and introduces additional permissibility conditions on re
Third-party generative AI services are increasingly embedded in organisational work, yet their emissions-related information is difficult for user organisations to access, interpret and govern. Scope 3-related reporting therefore raises an emerging information systems problem: how organisations can make supplier-dependent, uncertain and technically opaque emissions information traceable and usable
Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ Reconstruction of Regional and National Population Using Intermittent Census-Type Data: The Case of Portugal 1527-1864 NUNO PALMA, JAIME REIS, MENGTIAN ZHANG LUND PAPERS IN ECONOMIC DEMOGRAPHY 2019:7 Copyright is held by t
https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2019_7.pdf - 2026-07-19
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update PATHOGENESIS OF TYPE 1 DIABETES (A PUGLIESE AND SJ RICHARDSON, SECTION EDITORS) The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update Marian Rewers1 & Heikki Hyöty2,3 & Åke Lernmark4 & William Hagopian5 & Jin-Xiong She6 & Desmond Schatz7 & Anette-G Ziegler8 & Jorma Toppari9 & Beena Akolk
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/97%2001252019_679_097_REVIEW_Rewers_CurrDiabRpts_2018.pdf - 2026-07-19
1 REPORT FROM THE ROUND TABLE ON SOCIAL INCLUSION WITHIN A HUMAN RIGHTS FRAMEWORK IN THE NORDIC AND BALTIC STATES The programme is supported by a grant from the Foundation Open Society Institute in cooperation with OSIFE of the Open Society Foundations. 2 Background As is evident from any recent news report, Europe is being seriously challenged by the number of refugees currently seeking asylum wi
https://rwi.lu.se/app/uploads/2016/04/Report-Round-Table-on-Social-Inclusion-final-2.pdf - 2026-07-19
