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he case that constitutes the subject for this paper is a voluntourism project organized in the Faroe Islands that has gained worldwide attention. Unskilled volunteers were called to perform maintenance works while popular hiking trails remained closed for regular tourists. The idea turned into a successful marketing campaign for the Faroe Islands. Our study is anchored in theories on tourism desti

Objectives Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in the IMI-APPROACH cohort at baseline and analysed using a machine learning approach in order to study OA-dominant phenotypes driven by the endotype-related clusters and discover the driving fea

We present a study of the evolution of cosmic filaments across redshift with an emphasis on some important properties: filament lengths, growth rates, and radial profiles of galaxy densities. Following an observation-driven approach, we built cosmic filament catalogues at z = 0, 1, 2, 3, and 4 from the galaxy distributions of the large hydro-dynamical run of the MilleniumTNG project. We employed t

Popular Abstract in Swedish I den här doktorsavhandlingen presenteras ett datorprogram som utvecklats för att simulera och utvärdera biotekniska processer, där flera processteg kan vara integrerade. Speciellt har en process för framställning av mjölksyra från vetemjöl studerats. Mjölksyra har traditionellt använts i kemi-, läkemedels- och livsmedelsindustrin som t.ex. råvara, surgörare eller konseBiotechnical processes are often integrated to increase productivity and yield. It is difficult to predict the effects of process integration and to find optimum conditions for the process. A valuable tool for the evaluation of a complete process is mathematical modelling. In this thesis, a computer program developed for simulation and optimisation of integrated biotechnical processes is presented

Platform development provides software organisations with means to quickly respond to changing consumer needs. Product reuse and improved development efficiency can be achieved if platform development is introduced. A major challenge when using software platforms to produce a variety of products is to keep a high quality of the platform throughout the development of the products. It is therefore

Identifying the genes that underlie phenotypic variation in natural populations, and assessing the consequences of polymorphisms at these loci for individual fitness are major objectives in evolutionary biology. Yet, with the exception of a few success stories, little progress has been made, and our understanding of the link between genotype and phenotype is still in its infancy. For example, alth

The X chromosome (chrX) represents one potential source for the "missing heritability" for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the benefits of including chrX in GWAS by assessing the contribution of 404,862 chrX SNPs to levels of twelve commonly studied cardiometabolic and anthropometric traits in 19,697 Finni

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combin

Local environmental and ecological conditions are commonly expected to result in local adaptation, although there are few examples of variation in phenotypic selection across continent-wide spatial scales. We collected standardized data on selection with respect to the highly variable plumage coloration of pied flycatcher (Ficedula hypoleucaPall.) males from 17 populations across the species' bree

Mega-projects are a growing phenomenon worldwide. More and more projects are started and they grow ever bigger in size. At the same time, there is overwhelming evidence that mega-projects tend to run late, overrun in terms of costs and fail to deliver the expected benefits. Paradoxically, more and more money is invested in projects that fail to deliver on their promises.This dissertation analyses

BACKGROUND: Healthcare environment can affect health. Adverse events (AEs) are common because rapid changes in the patients' status can suddenly arise, and have serious consequences, especially in intensive care. The relationship between the design of intensive care units (ICUs) and AEs has not been fully explored. Hence, an intensive care room was refurbished with cyclic lightning, sound absorben

Internal positivity offers a computationally cheap certificate for external (inputoutput) positivity of a linear time-invariant system. However, the drawback with this certificate lies in its realization dependency. First, computing such a realization requires finding a polyhedral cone with a potentially high number of extremal generators that lifts the dimension of the state-space representation,

Gambella is one of the regional states in Ethiopia where huge tracts of land have been leased out to domestic and international investors since the global food, fuel and financial crisis of 2007/2008. The Gambella region is also one of the most marginalized regions in Ethiopia. It has been alienated from the central politics and socio-economic activities of the state. In the past, the Gambella reg

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis. Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria cove

The carbon cycle of the terrestrial biosphere plays a vital role in controlling the global carbon balance and, consequently, climate change. Reliably modeled CO2 fluxes between the terrestrial biosphere and the atmosphere are necessary in projections of policy strategies aiming at constraining carbon emissions and of future climate change. In this study, SMOS (Soil Moisture and Ocean Salinity) L3

Despite numerous studies of selection on position and number of spectral vision bands, explanations to the function of narrow spectral bands are lacking. We investigate dragonflies (Odonata), which have the narrowest spectral bands reported, in order to investigate what features these narrow spectral bands may be used to perceive. We address whether it is likely that narrow red bands can be used t

Purpose: The purpose of this study is to explore warehouse configuration in omni-channel retailing. Design/methodology/approach: A multiple case study is conducted with six large omni-channel retailers from three different sectors. Findings: The study shows an increase in the number, variation and frequency of flows passing through omni-channel warehouses. Along with an increased variety of stock

Background: PET/CT may be more helpful than CT alone for radiation therapy planning, but the added risk due to higher doses of ionizing radiation is unknown. Objective: To estimate the risk of cancer induction and mortality attributable to the [F-18]2-fluoro-2-deoxyglucose (FDG) PET and CT scans used for radiation therapy planning in children with cancer, and compare to the risks attributable to t

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals

Immersing a user in life-like extended reality (XR) scenery using a head-mounted display (HMD) with a constrained form factor and hardware complexity requires remote rendering on a nearby edge server or computer. Millimeter-wave (mmWave) communication technology can provide sufficient data rate for wireless XR content transmission. However, mmWave channels exhibit severe sparsity in the angular do