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Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important etiopathogenic event in SLE, which could contribute to the increased load of poten

National goals regarding sustainable development from the Swedish government were decisive in the planning process when the newly built city district Western Harbour was established in the city of Malmo, Sweden. A systems analysis was used as a tool for evaluating different collection and treatment systems. This type of analysis does not include more subjective factors such as acceptance of organi

The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti

Following the East Asian success story Indonesia also subscribed to a model with increased productivity, income and equity through modernisation of agriculture. When it was hit by a severe crisis in 1997, Indonesia was regarded as one of the up and coming tigers of Southeast Asia. The crisis indicated that something was seriously wrong in the structure of the economy necessitating a re-examination

Background: Auditory event-related potentials (AERPs) can be used as indices of neural information processing. Altered AERPs have been reported in children and young adults with frontal lobe infarction. Aim: To test the hypothesis that perinatal brain injury affects cortical auditory processing. Methods: We assessed AERPs at term. 6 and 12 months of age in preterm infants [n = 9. median gestationa

Popular Abstract in Swedish Hur kommer det sig att liknande reformprogram återfinns i olika länder? Varför väljs vissa idéer framför andra? Avhandlingen syftar till att öka förståelsen av så kallad policydiffusion, spridning av olika typer av policy, och den dynamik som omgärdar spridningen. Detta görs genom att undersöka hur externa, eller utländska, idéer integreras och översätts i en ny omgivniSimilar policies may be found in different countries. This, in turn, is an indication that policies travel. But why are certain policies imitated while others are not? The author seeks to further our understanding of policy diffusion and its dynamics by investigating how foreign ideas are integrated and translated into new contexts, and how these imported ideas influence national policymaking and

Multi-target aptamer selection, known as multiplex systematic evolution of ligands by exponential enrichment (SELEX), is rapidly drawing interest because of its potential to enable high-speed, high-throughput aptamer selection. The parallelization of chemical processes by integrating microfluidic unit operations is a key strategy for developing a multiplex SELEX process. One of the potential probl

Concerns have been raised about the marketization of science through the prevailing funding regime. However, the present article will discuss how it comes that the potentially marketable stem cell science is not more commercialized than what is currently the case. We approach this question by analysing discursive pluralism in defining the value of stem cells within a grant allocation process. More

The question asked in this thesis is: what is the impact on the democratic legitimacy of the legal orders of the member states of the EU, where the meaning of EU fundamental rights is determined by the Court of Justice of the EU. It begins by developing a theoretical framework which reconstructs the deep structure of the law of the member states, in order to understand the ground of legitimacy for

This research paper investigates the suitability of ceramic multi-component materials, which are found on the Martian and Lunar surfaces, for 3D printing (aka Additive Manufacturing) of solid structures. 3D printing is a promising solution as part of the cutting edge field of future in situ space manufacturing applications. 3D printing of physical assets from simulated Martian and Lunar regolith w

Popular Abstract in Danish Omkring halvdelen af den globale kulstof mængde som findes i jorden, er lagret i de arktiske jorde. Arktiske jorde har været anset for at være vigtige kulstof reservoirs de sidste 10.000 år, hvor der bliver optaget mere kulstof end der frigives. Dette skyldes blandt andet den langsomme omsætning af organiske materiale på grund af de kolde forhold, men også de store mængdArctic ecosystems hold massive amounts of the global carbon in their soils and are of great importance for the global terrestrial exchange of greenhouse gases to the atmosphere. The arctic region has in general been acting as a C sink for the past 10000 years, however with climate change the C balance in some areas is shifting towards becoming a C source. Herbivory are an important part of many ec

Popular Abstract in SwedishUnder slutet av 1950-talet, ungefär samtidigt med tv:s etablering, innehade Sverige Europarekordet vad gäller antalet biografer. Folk gick på bio som aldrig förr. Biograferna att spela en mycket stor roll för film- och biografkulturens tillgänglighet och spridning. Den här boken handlar om att gå på bio. Genom att gå på bio lärde sig människor att se och uppleva film ochGoing to the Pictures The Cinema as a Meeting Place in the 1940s and 1950s Summary At the end of the 1950s, at roughly the same time as television became established, Sweden had the largest number of cinemas of any country in Europe. People went to the cinema in unprecedented numbers. In 1956 ticket sales in Swedish cinemas reached 80 million. There were palatial cinemas which offered people a f

Psykiskt störda lagöverträdare har sedan länge särbehandlats inom straffrätten. I Sverige aktualiseras numera särbehandlingen vid påföljdsvalet. För att påföljdsvalet överhuvudtaget ska komma på fråga krävs att gärningspersonen kan tillskrivas skuld; antingen genom uppsåt eller, vid vissa särreglerade brott, oaktsamhet. Eftersom uppsåt inte är objektivt iakttagbart är uppsåtsbedömningen vanligen eMentally disordered offenders have been specially treated in criminal law for a long time. In Sweden, the special treatment occurs when the choice of sanction is decided. The choice of sanction only becomes relevant when the perpetrator is attributed debt; either through criminal intent or, in certain regulations, negligence. Since criminal intent is not objectively observable, the intent assessme

Den additiva tillverkningsprocessen och kvalificeringen av komponenter i metall är komplex och tillverkningsmetoden är inte ännu fullständigt förstådd. Syftet med detta examensarbete är därför att förvärva kunskap om kvalificeringsprocesser kopplade till additiv tillverkning i metall och att utveckla en hållbar kvalificering för additivt tillverkade komponenter hos Alfa Laval. KvalificeringsprocedThe process of additive manufacturing and qualification of components in metal is complex, and the manufacturing method is still not fully understood. Therefore, the purpose of this thesis is to gather knowledge of the qualification procedures connected to additive manufacturing in metal and to develop sustainable qualification for additively manufactured parts at Alfa Laval. The qualification pro

Integration of immigrants has become a crucial policy-question in Sweden and Western Europe due to the large numbers of immigrants having settled during the last three decades. Previous research has focused on integration policy outcome by studying the design of different policies and programs. This study addresses the question of how the Somali refugees, which are being better integrated in other

Abstract The focus of this thesis is to study and model the capacity of the bank to trade on the bonds market under normal and stressed conditions. This capacity is related to the liquidity of bonds market (ie, the ability to trade) and bank’s trading desks capacity to trade. All banks have different models but all are subject to the validation of the bank in a first place and the EU Central Bank