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Background/Objectives A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage.We elucidate how the gene/protein dynamics for a core transcriptional module governs this important process by computational means. Methods We

Recovering nutrients from urine as solid minerals such as struvite can eliminate many hurdles related to the use of liquid urine as fertilizer in the current urine separation systems. The focus of this study has been to increase nitrogen and phosphorus removal efficiencies by developing a struvite formation and recycling process. Struvite crystallization was carried out in urine samples by additio

This master thesis investigates material characterization by reflection and transmission of electromagnetic waves in the 40-60 GHz band (millimeter-wave spectrum) for different materials. The free-space measurement method is a fast, efficient and non-destructive way of examining a material and is being researched by both academics and industries. The theory of how electromagnetic waves interact w

New products on the market are likely to be simulated in a computer sometime during the development process. The environment for which the physical model of the product is developed may not always be the optimal for control simulations of the model. To be able to export models from one environment to another a common model definition must be defined. The Functional Mock-up Interface, FMI, provides

Detta examensarbete är ett samarbete mellan Institutionen för Industriell Produktion på Lunds Tekniska Högskola och Trelleborg AB. Målet med arbetet är att analysera polymerhanteringen i Trelleborgs mixing-avdelning utifrån ett lean perspektiv, samt att komma fram till ett nytt förbättrat produktionsflöde. Det nya flödet ska vara effektivare när det kommer till kapacitet, operatörstid, trucktranspThis thesis is a collaborative project between the division of Production and Materials Engineering and Trelleborg AB. The aim of the thesis is to analyse the current pre-batch polymer handling process, assess the current process from a Lean perspective, and provide a new handling process which is more effective in terms of capacity, operator time, forklift transportation and traceability. The cur

The purpose of this thesis is to explore the factors, circumstances and insights influencing Swedish organizations in their own transitioning process towards AI. The work conducted within this thesis results in a qualitative report where a number of focus areas are reviewed in an attempt to first provide a holistic picture surrounding the definitions, contexts, activities and mindsets involved in

From 2002 to 2015, the Iranian nuclear program was a central issue of U.S. foreign policy. This issue was addressed by the administrations of Presidents George W. Bush and Barack Obama who had significantly different approaches to said issue. Consequently, the discourse used to address the issue was also different. This study argues that in addressing the issue of the Iranian nuclear program, ther

I takt med den globala urbaniseringen växer städerna. I storstäderna finns en stor brist på obebyggd mark vilket leder till att städerna förtätas, något som medför nya risker när en större mängd människor befinner sig på en mindre yta. Att inkludera riskhantering i stadsbyggnadsprocessen är därför en av flera viktiga delar i utvecklingen av städerna. Processen för stadsbyggnad kan ses som en proce

The study has shown that BIM is used extensively throughout the entire construction process, with clear benefits and optimizations. The broad usage of BIM shows that all areas have streamlined and become less costly. BIM is well established in the construction process with an exception for the facility management phase. The benefits in the facility management area are well studied but not introduc

Växtprotein - lösningen för bekämpning av typ 2 diabetes? Mer än 400 miljoner människor i världen lider av diabetes typ 2 vilket gör det till en avde vanligaste folkhälsosjukdommarna enligt World Health Organisation (WHO). Thiazolidinediones (TZDs) används vid behandling av typ 2 diabetes då det höjer känsligheten för insulin. Kunskap om mekanismen kring TZD har tidigare varit begränsad vilket reMore than 400 million people in the world have type 2 diabetes, making it one of the most common diseases internationally according to the World Health Organization. Thiazolidinediones (TZDs) is used to treat type 2 diabetes since it increases the sensitivity of insulin in peripheral tissues. The knowledge about the mechanism how TZD works is limited which has resulted in patients getting serious

Den riskfördelning som AB 04 föreskriver anses utmärka sig i förhållande till andra standardavtal som tillämpas utanför byggbranschen. Entreprenören anses ha ett osedvanligt strängt ansvar som dessutom sträcker sig över en lång tid, samtidigt som reklamationstiden är relativt kort. Något som också särpräglar AB 04 är att det där finns en avtalad plikt för entreprenören att hålla entreprenaden försIt is a common opinion that the risk management that comes with AB 04 differs from the risk management in other standard contracts that is used in other fields than construction. The contractor is thought to have a uncommonly heavy burden in carrying the risk for the construction and the time, during which the contractor is carrying the risk, is stretching over a long time. Another thing that is d

In order to study and evaluate the care provided at the Intensive Care Unit (ICU), an accurate model to assess severity of illness and predict patient mortality based on admission data is required. Since 1983, the Simplified Acute Physiology Score (SAPS) based on logistic regression (LR) has become one of the international standards for this purpose and is used in Sweden for adults. While being a

Att en gärningsperson företagit en kontrollerad handling som lett till en okontrollerad följd är ett av kraven i den svenska straffrätten för att uppfylla rekvisiten för straffansvar i den modell för ansvar för en brottsbeskrivningsenlig gärning, beskriven av straffrättsprofessor Nils Jareborg och som tillämpas i svenska domstolar. Vid en analys av NJA 2012 s. 45 föreföll definitionen av vad somA necessity in the Swedish system for criminal liability is first that the person charged has committed a criminal act and that the criminal act is a result of a “controlled action” that leads to an uncontrolled consecution. This model is described by the professor of criminal law Nils Jareborg and is applied in Swedish courts. When I read the case NJA 2012 s. 45, from the supreme court of Sweden,

The interactions between airway epithelial cells (AECs) and dendritic cells (DCs) play an important role in the sensitization towards airborne allergens. Not much is known about the underlying mechanisms and novel in vitro approaches are needed, which include the different involved cell types in order to investigate what happens at the molecular level during sensitization. In this project, one aim

Syftet med detta examensarbete är att undersöka attityder hos 4 instrumentallärare kring att ge beröm till sina elever. Lärarna har intervjuats om vad de har för tankar kring att ge beröm. Som utgångspunkt för varje intervju ligger dokumentation och observation av ett lektionstillfälle med fokus på beröm. Resultatet visar att instrumentallärarna tycker det är viktigt att berömma sina elever. De ärThe aim of this paper is to investigate the attitudes of 4 instrumental teachers towards giving praise and speaking highly of their pupils. In order to account for the attitudes towards giving praise, four instrumental teachers have been interviewed. The interviews are based on one classroom observation of each teacher, focusing on giving praise. According to the results, the teachers find it cruc

The purpose of this work is to investigate if Miljöbyggnad certification works well for a building company in different regions of Sweden, or if a new or revised working method needs to be developed. To achieve the purpose, the author bases the study from a couple of interviews. The conclusion of the study showed that the Miljöbyggnad certification is rarely required at the Swedish building comp

Uppsatsen syftar till att diskutera om miljöbalkens målsättning är miljömässigt godtagbar. Frågeställningen är om innebörden av en hållbar utveckling utifrån den utveckling av begreppet som sker i relation till forskningen om planetära gränsvärden kan sägas vara inom ramen för målsättningen om hållbar utveckling i miljöbalkens portalparagraf. Först presenteras rättsvetarna Kim och Bosselmanns syThe purpose of this essay is to discuss if the objective of the Swedish Environmental Code (EC) is environmentally acceptable. The question asked is if the meaning of a sustainable development according to the development of the concept that is occurring in relation to research about planetary boundaries is within the scope of the objective of sustainable development in the preamble of the EC. At

All government controlled business is controlled by the law of public procurement and its five fundamental principles. If these are not fulfilled the procurement is at risk of being subject to a review procedure, which requires both time and money. Therefore it is important to ensure the quality of these processes for contracting authorities such as Region Skåne, especially in conjunction with the

Through recent years, RNA has rapidly gone from mainly being known as a passive information-carrying molecule within the central dogma of molecular biology to becoming the active ingredient in multiple therapeutics, such as in vaccines and potential drugs against cancer. However, one of the main challenges with RNA as a therapeutic is efficient delivery to cells. Understanding the mechanism throug