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The evolution of multiple active site configurations in a designed enzyme

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the many phenomena that have been suggested to contribute to catalysis. In this work, we fo

Shuffling Active Site Substate Populations Affects Catalytic Activity : The Case of Glucose Oxidase

Glucose oxidase has wide applications in the pharmaceutical, chemical, and food industries. Many recent studies have enhanced key properties of this enzyme using directed evolution, yet without being able to reveal why these mutations are actually beneficial. This work presents a synergistic combination of experimental and computational methods, indicating how mutations, even when distant from the

Analysis of particle size distribution changes between three measurement sites in Northern Scandinavia

Measured aerosol size distributions from three measurement stations and modeled air mass trajectory data were combined to study aerosol dynamics in the boreal forest zone in Northern Scandinavia. Three approaches were used: investigation of new particle formation events, analysis of air masses arriving from ocean to continent, and study of changes in the aerosol size distributions when air masses

Optimal Landfill Site Selection for Solid Waste of Three Municipalities Based on Boolean and Fuzzy Methods: A Case Study in Kermanshah Province, Iran

Acoustic mapping of submerged stone age sites—A HALD approach

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

Differential effects of tree species identity on rhizospheric bacterial and fungal community richness and composition across multiple trace element-contaminated sites

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Researchers’ use of social network sites : a scoping review

Adsorption sites in O and CO coadsorption phases on Rh(111) investigated by high-resolution core-level photoemission

On the adsorption sites for CO on the Rh(111) single crystal surface

Dinuclear metal complexes modelling active sites of metallohydrolases

Investigating temporal relationships between rainfall, soil moisture and MODIS-derived NDVI and EVI for six sites in Africa

Completion of registration of risk factor variables during telephone vs on-site follow-up after myocardial infarction : a nationwide observational study in 101 199 patients from contemporary clinical practice in Sweden

Buxus sempervirens and Laurus nobilis leaves from an archaeological site at 7300 cal BP (La Draga, Spain) provide a better understanding of past vegetation and human activities

Release of halide ions from the buried active site of the haloalkane dehalogenase LinB revealed by stopped-flow fluorescence analysis and free energy calculations

Presentation erncip jrc 20160428 v3

PowerPoint Presentation LUND UNIVERSITY | LTH | Division of Risk Management & Societal Safety | Jonas Johansson | 2016-04-28 Society’s Dependence on Resilient Critical Infrastructures – National and Regional Scales JONAS JOHANSSON, LUND UNIVERSITY ERNCIP/IMPROVER WORKSHOP, JRC, ISPRA, ITALY, 20160428 LUND UNIVERSITY | LTH | Division of Risk Management & Societal Safety | Jonas Johansson | 2016-04-

https://www.cencip.lu.se/sites/cencip.lu.se/files/presentation_erncip_jrc_20160428_v3.pdf - 2026-06-06

Construction, Destruction, and Safety: A cross-sectional study of the measurement of and relationship between safety climate, destructive leadership, and risk behavior on construction sites in Sweden

Are Restriction Enzymes Recognition Sites Underrepresented in the Organisms That Host Them?

Exploration of an all-atom thermodynamic model to predict site-specific evolutionary rates in proteins