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Effect of Pramipexole on Nucleus Accumbens Resting State Functional Connectivity in Anhedonia – an fMRI Study

Anhedoni, minskad motivation att uppleva lust, är associerad med förändringar i belöningssystemet. Belägen i ventrala striatum utgör den bilaterala nucleus accumbens (NAcc) den centrala noden i detta nätverk, där dopamin agerar som huvudsaklig excitatorisk neurotransmitter. Studier med funktionell magnetresonanstomografi (fMRI) har visat att aktiviteten i ventrala striatum minskar under belöningsbAnhedonia, reduced motivation to experience pleasure, is associated with alterations in the circuitry of the reward system. Located in the ventral striatum, the bilateral nucleus accumbens (NAcc) is the central hub of this network where dopamine acts as the main excitatory neurotransmitter. Studies using functional magnetic resonance imaging (fMRI) found that activity in the ventral striatum is de

Quality-policy-for-lund-university

Lägg till titel Page 1 of 1 REGULATORY DOCUMENT COVER PAGE Quality Policy for Lund University Type of regulatory document: Policy Definition of the type of regulatory document: Policies express the management’s overall intended direction or values that are to be taken into account within the area covered by the policy, set frameworks for a specific course of action and constitute a strong recommen

https://www.staff.lu.se/sites/staff.lu.se/files/2025-02/quality-policy-for-lund-university.pdf - 2026-06-20

Intraventricular Infusion of TrkB-Fc Fusion Protein Promotes Ischemia-Induced Neurogenesis in Adult Rat Dentate Gyrus.

Background and Purpose-We have previously shown that delivery of brain-derived neurotrophic factor (BDNF) through direct intrahippocampal gene transduction with a viral vector suppresses the formation of new dentate granule cells triggered by global forebrain ischemia. Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus. Methods-Rat

Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation

Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd)