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We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 dia
Net primary production (NPP) is the difference in gross photosynthetic assimilation of carbon and carbon loss due to autotrophic respiration, and is an important ecosystem variable that facilitates understanding of climate change impacts on terrestrial ecosystem productivity and ecosystem services. The aim of this study is to rapidly estimate the NPP of European potential natural vegetation for cu
Atmospheric aerosol particles have substantial influence on climate and air quality. However, the anthropogenic influence on the atmospheric aerosol is still poorly known. This limits the understanding of past and future climate changes. Additionally, both epidemiological and toxicological studies indicate adverse health effects of inhaled aerosol particles. In order to study the effect of atmosph
This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.RESEARCH DESIGN AND METHODS: A group of experts participated in a conference on 14-16 October 2013 cosponsored by the Endocrine Society and the American Diabetes Association. A writing group prepared t
BACKGROUND: Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially. APPROACH: An expert committee compiled evidence-based recommendations for the use of laboratory testing for patients with diabetes. A new system was developed to grade the overall quality of the evidenc
This study evaluated a technique to allow the long-term monitoring of individual fishes of known sex in the wild using sex confirmation in close proximity to the reproductive period combined with individual tagging. Hundreds of partially migratory roach Rutilus rutilus were tagged with passive integrated transponders (PIT) following sex determination in spring and various performance measures were
As new technologies emerge such as wearables, it opens up for new challenges, especially related to security and privacy. One such recent technology is smart glasses. The use of glasses introduces security and privacy concerns for the general public but also for the user itself. In this paper we present ongoing theoretical work which focus on privacy of the user during authentication. We propose a
Objective. To follow patients with fibromyalgia six and 24 months after they finished a six-month treatment programme. The programme comprised pool exercise therapy, adjusted to the patients' limitations, and education based on their health problems. Methods. Twenty-six patients were examined six and 24 months after the completion of the treatment programme with the Fibromyalgia Impact Questionnai
In the microelectronics industry, gold electrodes on silicon dioxide are produced using an adhesive layer of chromium or titanium. This method is applicable whenever a dry environment is present. However, when such an electrode is exposed to an electrolyte a galvanic cell is formed and the less noble metal will dissolve and eventually destroy the electrode. We describe here how a monolayer of merc
This article proceeds from the argument that various forces of globalization have resulted in increased dislocation and uncertainty for many people in the world. Religion and nationalism, compared to most other identity constructions, are viewed as particularly relevant organizing principles at a time when modern society is making increasing demands on individuals. In comparison to much constructi
In order to allow different software applications, in constant evolution, to interact and exchange data, flexible file formats are needed. A file format specification for different types of content has been elaborated to allow communication of data for the software developed within the European Network of Excellence "NANOQUANTA", focusing on first-principles calculations of materials and nanosyste
Popular Abstract in Swedish Adenovirus från människa (Ad) används ofta vid genterapi mot cancer, vaccinutveckling och genöverföring. Modifierade Ad5 och Ad2 virus har framgångsrikt använts som cancercelldödande (onkolytiska) agens i experimentella studier som dock inte kunnat överföras till kliniskt bruk av flera skäl, inklusive bristande spridning av virusinfektionen inom tumörvävnaden. De onkolyHuman adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is
This article presents the methodological requirements for clinical examination and patient-reported outcomes measurements. The assessment of any measurement for clinical research in hand surgery is difficult. A method of measuring a criterion could be 100% reliable but 100% invalid. Bias may be present in our assessment if we do not take into account the methodological requirements related to reli
Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework f
