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In the last three decades, extensive research on human immunodeficiency virus (HIV) has highlighted its capability to exploit a variety of strategies to enter and infect immune cells. Although CD4+ T cells are well known as the major HIV target, with infection occurring through the canonical combination of the cluster of differentiation 4 (CD4) receptor and either the C-C chemokine receptor type 5
Popular Abstract in Swedish Förekomsten av fetma ökar lavinartat över hela världen, Sverige inte undantaget, och detta är en stor bidragande orsak till att antalet fall av typ 2 diabetes tilltar på ett liknande sätt. Både fetma och typ 2 diabetes är sjukdomar med ett komplicerat mönster av samverkande genetiska och miljömässiga faktorer. Drabbade individer har en klart ökad risk att drabbas av hjäThe worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. FOXC2 encodes a forkhead transcription factor, which was identified as a key regul
Background/Aims: Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. Methods: 152 mice were investigated with a well-known adhesion model and given different concentrations of t
Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the sing
The cavitation phenomenon has today become a keystone for different areas of science and technology including various industrial processes and medicine. Recently increasing interest and much attention have been paid to study this phenomenon. The last two decades have witnessed the development of numerous devices for different important applications of considerable practical interest, and the rang
In this thesis, liquid-membrane-based methods for the analysis of trace metal species in samples of environmental and biological origin were developed. By incorporating extracting reagents in the membrane liquid, trace metal ions were selectively separated from humic-rich natural waters and urine samples, prior to their determination using various instrumental techniques. The extractions were perf
Knowledge about the nature, processes and patterns of cascading effects, i.e. where infrastruc-ture dependencies lead to impacts propagating from one system to other systems, is essential in order to miti-gate and respond to crises that involve critical infrastructures and societal functions. This paper presents a method for systematic description of cascading effects in past event, to some extent
Diet has a pivotal role in shaping the composition, function and diversity of the gut microbiome, with various diets having a profound impact on the stability, functionality and diversity of the microbial community within our gut. Understanding the profound impact of varied diets on the microbiome is crucial, as it will enable us not only to make well-informed dietary decisions for better metaboli
The number of degrees of freedom is a crucial parameter in many electromagnetic problems. In for example modern communication systems spatial diversity is often employed through multiple beams to enhance capacity and reliability. However, while the degrees of freedom can be computed, their connection to physical quantities is not as easily understood. To address this issue, this paper proposes a s
Business Rules (BR) and Business Processes (BP) are essential pillars in any Business Information System (BIS) and important areas of BIS design (BISD). Historically, BRs have been overlooked as a part of BISD. The Business Rules Approach (BRA) focuses on concepts and methods to remedy the neglected BR design and management. BRs in this perspective are stateless and concerned with the “what” of a
Desalination is an important method for producing drinking water and it has been a freshwater supply alternative for a long time. The water resources in the Gulf Cooperation Council (GCC) countries, are mostly depending on desalination as a major source of (>80 %) drinking water, while the rest comes from groundwater. The largest number of desalination project is located in the Gulf countries (Sau
In economic, scientometric and innovation research, often so-called specialization indices are used. These indices measure comparative strengths or weaknesses as well as specialization profiles of the observation units with respect to certain criteria, such as patenting and publication or trade activities. They allow question like: is Germany specialized in the export of motor vehicles? Or is the
Engaging students in active participation and collaborative learning is an important pedagogical component of teaching and learning in higher education. Teachers use a variety of activities to engage students, such as interactive lectures, presentations, group activities, and projects. A metaphorical understanding of the teaching-learning process may help in the implementation of innovative and gr
Drawing upon literature from both impact assessment of development projects and agricultural research, the aim of this article is to analyse the pilot testing of a new multi-dimensional assessment framework for defining and evaluating the societal impact of agricultural research and corresponding education. The research approach involves an action research effort of pilot testing in three case stu
We present a unique comparative analysis, and evaluation of vision, radio, and audio based localization algorithms. We create the first baseline for the aforementioned sensors using the recently published Lund University Vision, Radio, and Audio (LuViRA) dataset, where all the sensors are synchronized and measured in the same environment. Some of the challenges of using each specific sensor for in
At COP27, Parties agreed to establish a fund for loss and damage. During the COP28 opening plenary, the Loss and Damage Fund was operationalised. Despite this progress, significant questions about access to funding remain unanswered. We engage with a key term in the decision texts–particularly vulnerable. How Parties frame and define the term ‘particularly vulnerable’ will influence funding alloca
