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Background Signal transduction pathways convey information from the outside of the cell to transcription factors, which in turn regulate gene expression. Our objective is to analyze tumor gene expression data from microarrays in the context of such pathways. Results We use pathways compiled from the TRANSPATH/TRANSFAC databases and the literature, and three publicly available cancer microarray da
Accessibility in public outdoor environments is an important issue for persons with reduced functional capacity, for example older persons, and is also crucial for older pedestrians’ safety. The aim of the paper is to evaluate the importance and satisfaction of accessibility issues in public outdoor environments the year around as perceived by older persons (65 years old and above). Within two bef
Broar över vattendrag utgör viktiga element i många transportsystem. Om broar kollapsar orsakas betydande problem med både direkta och indirekta kostnader för samhällsekonomin. Lokal erosion av botten kring broar är många gånger en huvudorsak till brokollaps, ofta i samband med extrema flödessituationer. Risken för sådan lokal erosion kan bli större i samband med en framtida klimatförBridges are important components in many transportation networks often spanning rivers and other water bodies. The failure of a bridge will cause significant direct and indirect economic losses to society. Scouring of the river bed around bridges is a principal mode of bridge failure typically associated with large floods. The risk of such scour may become higher with the emerging climate chang
Job stress and burnout are highly prevalent in healthcare professionals, and nurses in particular. Given its deleterious consequences not only for professionals’ well-being but also for patients and organizations, it is important to have adequate measures to assess professional quality of life. This study aimed to offer a contribution for the Portuguese validation of the Professional Quality of Li
The use of low-cost immersive virtual reality systems is rapidly expanding. Several studies started to analyse the accuracy of virtual reality tracking systems, but they did not consider in depth the effects of external interferences in the working area. In line with that, this study aimed at exploring the static-positional accuracy and the robustness to occlusions inside the capture volume of the
Temperature is one of the key abiotic factors during the life of plants, especially in the Arctic region which is currently experiencing rapid climate change. We evaluated plant traits and environmental variables determining leaf temperature in tundra shrubs and volatile organic compound (VOC) emissions with field measurements on deciduous tundra shrubs, Salix myrsinites and Betula nana, and everg
Abstract This paper explores the relationship between social engagement and motivation to share knowledge in a hybrid college class using a web infused curriculum. Online social engagement, operationalized through concepts such as connectivity, social presence and social space has been an important topic of research in web based education for more than a decade. An important sub-text of this resea
This work is focused on synthesis, characterization, and determination of main parameters of the multilayer P123 templated TiO2 films. The mesoporous multilayer thin films consist of TiO2 nanoparticles on the F-doped SnO2 (FTO) conductive glass substrates. The films were grown by implementing the protocol of supramolecular templating with the amphiphilic triblock copolymer, Pluronic P123. The temp
The characteristics of the stellar populations in the Galactic bulge info and constrain the Milky Way's foation and evolution. The metal-poor population is particularly important in light of cosmological silations, which predict that some of the oldest stars in the Galaxy now reside in its centre. The metal-poor bulge appears to consist of ltiple stellar populations that require dynamical analyses
PURPOSE: To investigate the: (1) percent of children with spina bifida (SB) complaining of pain, (2) frequency, duration, and cause of pain by sex, level of lesion type of SB, and ambulation status, (3) body sites reported to hurt, by variables in objective 2, and (4) associations between physical and mental/emotional health between caregiver and child.METHODS: Cross-sectional study of 101 caregiv
This study investigated the applicability of mixture experimental design-based modeling approach to analyze insecticidal activity of thyme essential oils, particularly focusing on the synergistic interaction of their major constituents against Musca domestica. Chemical compositions of twelve commercially available thyme oils were analyzed using GC-MS, revealing their major constituents to be α-pin
OBJECTIVES: To investigate utilisation patterns of different types of healthcare in a pre-pandemic and pandemic period, respectively, among children with intellectual disabilities in comparison to their age peers in the general population.STUDY DESIGN: Based on 8 years of register data, we identified 1947 children with intellectual disabilities (ID cohort) and 145 998 children from the general pop
How do expert committees sustain credibility while radically expanding their institutional scope? This question animates contemporary food governance, as dietary guidelines, historically focused on nutritional adequacy, increasingly incorporate environmental sustainability and demands for democratic participation. Yet scholarship has largely neglected the ongoing legitimacy work, the strategic fra
INTRODUCTION: Although there are more women than men working in the healthcare system in Europe, reports of gender-related inequities within the healthcare workforce are still emerging. Our study aimed to gather insights from women, representing different healthcare professions, who work in the field of geriatric medicine and gerontology, to better understand their perspectives and experiences.MET
The term “charisma” is recognized as sociology's most successful export to common speech. While sociologists habitually dismiss popular uses of the word, we address its vernacularity head on as a worthy object of study and as a potential resource for conceptual development. Using machine learning, we locate “charisma” within the wider discursive field out of which it arises (and continues to arise
Germline mutations are the ultimate source of genetic variation and the raw material for organismal evolution. Despite their significance, the frequency and genomic locations of mutations, as well as potential sex bias, are yet to be widely investigated in most species. To address these gaps, we conducted whole-genome sequencing of 12 great reed warblers (Acrocephalus arundinaceus) in a pedigree s
Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the cardiovascular system caused by deranged autonomic control of circulatory homeostasis. CVAD is an important component of post-COVID-19 syndrome, also termed long COVID, and might affect one-third of highly symptomatic patients with COVID-19. The effects of CVAD can be seen at both the whole-body level, with impairment of heart rat
