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Popular Abstract in English Organic synthesis has been defined as the “intentional construction of molecules by chemical means”1 and is often regarded to have commenced with Wöhler’s preparation of urea in 1828.2 Today, the influence of organic synthesis reaches far beyond the domain of chemistry, touching upon fields such as biology, nanotechnology, material science, and medicine. It has thus supThis thesis deals with the development of new reaction methodology for stereoselective synthesis, as well as total synthesis of natural products and investigations of the stereochemical outcome in the Mukaiyama aldol reaction. Chapter 2 describes efforts made towards the total synthesis of the oxindole natural products perophoramidine and the communesin. The first part of this chapter aims to de

Popular Abstract in Swedish Arbetare i gummiindustrin utsätts för ett stort antal kemikalier med hög giftighet. Tidigare forskning har visat att kemikalierna innebär en fara för hälsan. Gummiarbetarna har tidigare haft en ökad risk att drabbas av olika sjukdomar, t.ex. cancer, hjärtkärlsjukdomar och luftvägsbesvär, jämfört med allmänbefolkningen. Däremot vet man inte exakt vilka ämnen som är farliWorkers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. The general aim of this thesis was to find exposure-response relationships usable for risk assessments in the rubber industry. U

Recent magnetic-resonance work on Y-Z suggests that this species exhibits considerable motional flexibility in its functional site and that its phenol oxygen is not involved in a well-ordered hydrogen-bond interaction (Tang et al., submitted; Tommos et al., in press). Both of these observations are inconsistent with a simple electron-transfer function for this radical in photosynthetic water oxida

Popular Abstract in Swedish Bröstcancer är i dag den vanligaste cancerformen hos kvinnor i västvärlden. I Sverige insjuknar varje år drygt 6 600 kvinnor, och detta innebär att en av tio kvinnor kommer någon gång under sin livstid att utveckla bröstcancer. Antalet nydiagnostiserade fall av bröstcancer i Sverige har under de senare åren ökat, vilket bl.a. tros bero på den ökade medelåldern i befolknIn recent time breast cancer has become the most common form of female cancer in the western world. It has been estimated that the lifetime risk of women falling ill from the disease is 10%. The number of patients diagnosed each year has been increasing steadily since the 1970s. In 2002 the number of Swedish women diagnosed with breast cancer was 6,600, constituting every third female cancer diagn

Popular Abstract in Swedish Populärvetenskaplig sammanfattning (Summary in Swedish) Syftet med de studier som ligger till grund för denna avhandling är att klarlägga den genetiska och metabola bakgrunden till typ 2 diabetes (åldersdiabetes) och dess komplikationer. Typ 2 diabetes ökar mycket snabbt i Sverige och i världen och många forskare talar om en världsomfattande diabetesepidemi. Detta är aAbstract The present study evaluated genetic and metabolic factors influencing the risk for type 2 diabetes and cardiovascular disease (CVD) with special reference to increased concentrations of free fatty acids (FFA) in 1174 Swedish diabetic and nondiabetic subjects. Common polymorphisms in the fatty acid binding protein 2 (FABP2), the B2-adrenergic receptor (B2-AR), the B3 -adrenergic receptor

This study aims to deduce what Japanese native speakers think of the Japanese writing systems, and in particular what native speakers’ opinions are concerning Kanji, the logographic writing system which consists of Chinese characters. The Japanese written language has something that most languages do not; namely​ a total of three writing systems. First, there is the Kana writing system, which cons

Factor VIII (FVIII)-bypassing agents have complex modes of action but all control bleeding in inhibitor patients by triggering the generation of thrombin. No routine test is available for monitoring this therapy in patients with inhibitors against FVIII. We present an assay that records FEIBA- or FVIIa- mediated changes in thrombin generation (TG) in FVIII inhibitor plasma samples. In plasma sampl

PURPOSE: The purpose of this study was to identify genetic aberrations contributing to clinical aggressiveness of malignant peripheral nerve sheath tumors (MPNSTs). PATIENTS AND METHODS: Samples from 48 MPNSTs and 10 neurofibromas were collected from 51 patients with (n = 31) or without (n = 20) neurofibromatosis type 1 (NF1). Genome-wide DNA copy number changes were assessed by chromosomal and ar

OBJECTIVES: Untreated primary hyperarathyroidism (pHPT) is accompanied by an excessive morbidity in circulatory disorders, associated with blood pressure and diabetes. The aim of the present study was to further penetrate the impact of pHPT on glucose, urate, lipid and lipoprotein concentrations, known to be interrelated metabolic cardiovascular risk factors.DESIGN: Longitudinal study of patients

This dissertation consists of three empirical essays concerning social norms and their effect on economic outcomes. Each essays discusses a seperate subject. The first paper, Breaking the Glass Ceiling: Gender Norms and Women Executives in the United States studies social norms as a distal cause of differences between genders in corporate executive recruitment strategies. Using census-level panel This dissertation consists of three empirical essays concerning social norms and their effect on economic outcomes. Each essays discusses a seperate subject. The first paper, Breaking the Glass Ceiling: Gender Norms and Women Executives in the United States studies social norms as a distal cause of differences between genders in corporate executive recruitment strategies. Using census-level panel

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GR

Background: Recombinant factor VIIa (rFVIIa) is used to treat bleeds in hemophilia patients with inhibitors. A subcutaneous formulation could potentially improve its half-life and make it suitable for prophylactic treatment. Objectives: A study was conducted to determine the safety of subcutaneously administered rFVIIa in patients with hemophilia and the pharmacokinetic profile (including bioavail

BACKGROUND: The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of func

Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was su

Morphological studies have indicated that proximal nerve ends of transected rat sciatic nerves regenerating into preformed mesothelial chambers show a different organization as compared to neuromas developed in contact with a muscle fascia. We have studied the physiological properties of nerve fibres arising from these types of preparations with reference to ongoing activity, response to mechanica

Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWASs with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases an

The purpose of this essay is to describe the way the prepositions from and från work, both semantically and syntactically. However, the focus is on the translation from from into Swedish. The question this essay aims at answering is: “is there any mutual correspondence between English and Swedish use of their respective prepositions”? The question is relevant since a large amount of the literature

I denna uppsats undersöker jag hur nationell identitet, fiendebilder och historiskt minne konstrueras i den grekiska författarinnan Pinelopi Deltas (1874-1941) roman "Sta mystika tou Valtou". Romanen, utgiven 1937, har motiv från striderna mellan grekiska och bulgariska nationalister om herraväldet över Makedonien i början av förra seklet och har blivit en klassiker inom grekisk ungdomsl