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Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di
The emerging notion of hematopoietic stem and progenitor cells (HSPCs) as a low-primed cloud without sharply demarcated gene expression programs raises the question on how cellular-fate options emerge and at which stem-like stage lineage priming is initiated. Here, we investigate single-cell chromatin accessibility of Lineage-, cKit+, and Sca1+ (LSK) HSPCs spanning the early differentiation landsc
Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Suc
Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulating the release of small bioactive molecules. In the current study, we aimed to elucidate the identity
A modern diesel engine is a reliable and efficient mean of producing power. A way to reduce harmful exhaust and greenhouse gas (GHG) emissions and secure the sources of energy is to develop technology for an efficient diesel engine operation independent of fossil fuels. Renewable diesel fuels are compatible with diesel engines without any major modifications. Rapeseed oil methyl esters (RME) and o
BACKGROUNDThe accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is divi
Since the 1950s, no other material has been developed and used to the same extent as plastic. We have built up a society that has integrated plastics into virtually every aspect of our lives. With low material prices, cheap manufacturing methods and its versatility, plastic has quickly become a commodity in society that is consumed in an unsustainable way. Plastic pollution causes immense social,
This report is a study in fireworks safety with emphasis on the safety issues considering multiple tube devices. The report was produced in order to facilitate the examination of the risks of firework cakes tipping over during firing, as well as providing support for future studies. The availability of detailed Swedish statistics regarding accidents involving fireworks has proven to be deficient,
Abstract Uppsatsen Fienden Inifrån granskar medierapporteringen kring Anders Breivik – gärningsmannen bakom terrordåden i Oslo den 22 juli 2011 med syftet att nå djupare insikt i hur media konstruerar fienden när denne kommer inifrån det egna samhället, samt vilka konsekvenser denna konstruktion får. Genom att undersöka 16 artiklar publicerade i Dagens Nyheter analyseras mediekonstruktionen av fi
This study explores the political relationship between King Hussein and Margaret Thatcher, during her time as Prime Minister of Great Britain, 1979-1990. Through archival research, I explore data concerning the political situation and the bilateral relations of Jordan and Great Britain. These focus primarily on the political situation in the Middle East, as well as taking economic relations betwee
The European Union (EU) is heading for an increased economic, legal and political integration of its Member States. In spite of all the efforts to bring the people of Europe closer, significant differences in national laws and cultures still exist. Enhanced understanding of such disparities can create opportunities for companies operating on the EU market in several areas, including the way to dea
The present thesis explores perceptions about if and how are the EU norms adopted, adapted, resisted or rejected in the case of Kosovo. Moreover, a comparison between two parts within Kosovo will be conducted: a northern part with Serbian majority and the "rest of Kosovo" with Albanian majority. The objective is to investigate the effect of the EU normative power in different parts of a
