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A rapid and simple approach of lactose analysis is proposed based on 3rd generation amperometric biosensors employing cellobiose dehydrogenase (CDH) from Trametes villosa or Phanerochaete sordida immobilised on screen-printed carbon electrodes (SPCEs). After optimisation of the working conditions of the biosensors - pH of the carrier buffer, flow rate and applied potential - the sensors were able
BACKGROUND: Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer.METHODS: In this double-blind, placebo-contro
Many items of culture which are conveyed from one culture to another may take verbal form, and then constitute what Jakobson called "translation proper." If such diffusions involve a co-occurrent change of semiotic systems, they are of such a different nature, that we better reserve another term for it: transposition. Whether or not accompanied by transpositions, such as pictures, translational ev
Evaporation is an important component of the water and energy balance of lakes and reservoirs. The energy balance combination method for estimating evaporation requires the heat storage changes (Qt) to be known. The lack of data on water temperature profiles and water depth fluctuations hinders routine computations of Qt. Following successful estimation of the soil heat flux density of land surfac
Air traffic control activities demand a high level of safety performance. Methods for identifying and monitoring work and situational factors to enable safety performance improvements are rare. This paper reports on the development of such a questionnaire-based tool for the Swedish air navigation services provider. Results from interviews specified eight aspects to be assessed by the questionnaire
Objectives: The aim of this study was to explore the prevalence of eating difficulties and malnutrition among persons in hospital care and in special accommodations. Design: The cross-sectional observational study was performed in Nov. 2005. Setting: Hospitals and special accommodations. Participants: Out of 2945 persons, 2600 (88%) agreed to participate (1726 from special accommodations and 874 f
Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. Previous work showed that glucose activates the transcription factor Nuclear Factor of Activated T cells (NFAT) in arteries ex vivo. NF
The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e. g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and prog
Normal glucose homeostasis is characterized by appropriate insulin secretion and low HbA1c. Gene expression signatures associated with these two phenotypes could be essential for islet function and patho-physiology of type 2 diabetes (T2D). Herein, we employed a novel approach to identify candidate genes involved in T2D by correlating islet microarray gene expression data (78 donors) with insulin
Objective: The aim of this article is to present the Swedish and Norwegian Testicular Cancer Group (SWENOTECA), with an emphasis on the history of SWENOTECA, organization, results and current status. Materials and methods: SWENOTECA was founded in 1981 as a binational organization open to hospitals in Sweden and Norway treating testicular cancer. It has since published treatment protocols for test
Background: During their evolution in the Late Cretaceous, mosasauroids attained a worldwide distribution, accompanied by a marked increase in body size and open ocean adaptations. This transition from land-dwellers to highly marine-adapted forms is readily apparent not only at the gross anatomic level but also in their inner bone architecture, which underwent profound modifications. Methodology/P
A capture-mark-recapture study on the threatened saproxylic beetle Lucanus cervus was carried out in a chestnut (Castanea sativa) woodland located in northern Italy, using visual encounter surveys (VES) as well as aerial flight interception traps and pitfall traps (PT), both of which were baited with different odour lures. In total, 111 males and 25 females were captured, and VES was by far the mo
Background Few authors have investigated function and pain after surgical treatment of patients with bone metastases. In 1999 the Scandinavian Sarcoma Group (SSG) initiated the Skeletal Metastasis Registry as a multi-centric, prospective study to provide a scientific basis for recommendations of treatment. Patients and methods We have analyzed function and pain in 530 patients (mean age 65 yr) ope
Background and Objectives The aim of this study was to evaluate the pharmacokinetics, efficacy and safety of a newly developed 10% liquid immunoglobulin preparation in patients with primary immunodeficiency diseases. This new preparation for intravenous use includes three dedicated virus clearance steps in its manufacturing process to ensure a high margin of viral safety. Materials and Methods Thi
We previously identified matrilin-2 (MATN2), the largest member of the novel family of matrilins. These filament-forming adapter proteins expressed in a distinct, but partially overlapping, pattern in all tissues were implicated in the organization of the extracellular matrix. Matrilin-2 functions in a great variety of tissues. Here, we present the genomic organization of the highly conserved mous
Popular Abstract in Swedish Livstidsprevalensen för läkemedelsberoende hos alkoholberoende patienter varierar mellan 20% och 45%. I normalbefolkningen är livstidsprevalensen av läkemedelsberoende cirka 2%; livstidsprevalensen för beroende av bensodiazepiner (BZD) respektive legala opioider (metadon exkluderat) är 0.3-0.9% respektive 0.8%. Förskrivningen av BZD har de senaste åren legat konstant elThe thesis contains 4 papers, two clinical studies and two meta-analyses. In the BZD taper study (Paper I) 21 BZD dependent (DSM-IV) patients were included for a 10-day inpatient detoxification. The average defined daily dose (DDD) was 4.7 doses. Withdrawal symptoms were not more pronounced compared to more extended detoxification procedures reported in literature. Five patients, all with concomi
Two patients who developed frank arterial bleeding after combined microwave-induced hyperthermia and radiotherapy are described. One patient received re-irradiation and hyperthermia for recurrent metastatic neck nodes of a mesopharyngeal carcinoma. Full course radiotherapy had been given 6 years previously and a right-sided radical neck node dissection had been performed 4 months earlier because o
M proteins and other members of the M protein family, expressed on the surface of Streptococcus pyogenes, bind host proteins such as immunoglobulins, albumin, and fibrinogen. Protein H and the M1 protein are expressed by adjacent genes and both belong to the M protein family. In this work, the structure and stability of these two proteins have been investigated. As judged from sequence analysis an
Syntheses in the Al-Sb-V-O system, which is a candidate catalyst system for propane ammoxidation to acrylonitrile, were characterised by X-ray powder diffraction, electron diffraction, energy dispersive X-ray microanalysis, high-resolution electron microscopy, infrared spectroscopy, and catalytic measurements. The objective was to study phase formation as well as to identify the phase, or phases,
