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Background: CSF and PET biomarkers of amyloid β and tau accurately detect Alzheimer's disease pathology, but the invasiveness, high cost, and poor availability of these detection methods restrict their widespread use as clinical diagnostic tools. CSF tau phosphorylated at threonine 181 (p-tau181) is a highly specific biomarker for Alzheimer's disease pathology. We aimed to assess whether blood p-t
Abstrakt. Ett etablerat MP2RAGE-protokoll för semikvantitativ strukturell hjärn-MRI överfördes frånen 7T MR-skanner till en annan leverantör med jämförbar hårdvara, men motsatt polaritet. På det härsystemet, kan skanningstiden reduceras från 11 till 8 minuter genom elliptisk k-space-sampling. Tre konfigurationerav radiofrekvens (RF) överföring jämfördes (enkelkanal med kvadraturen slits, två och åAbstract. An established MP2RAGE protocol for semi-quantitative structural brain MRI was transferred from one 7T MR scanner to that of another vendor featuring comparable hardware, but opposite polarity. On this system, the scan time could be reduced from 11 to 8 minutes by elliptical k-space sampling. Three configurations of radio-frequency (RF) transmission were compared (single channel with qu
Detection of antineutrophil cytoplasmic antibodies (ANCA) has become a useful tool in the diagnosis of Wegener's granulomatosis and microscopic polyangiitis. However, the results obtained with indirect immunofluorescence (IIF) and by ELISA for ANCA demonstration do not always correlate. A possible explanation for this finding could be that proteins are denatured during the process of antigen purif
Abstract. In addition to the pheromone components (Z)‐5‐decenyl, (Z)‐7‐dodecenyl and (Z)‐9‐tetradecenyl acetate (Z5‐10:OAc, Z7‐12:OAc and Z9‐14:OAc), it has previously been shown that the sex pheromone gland of the turnip moth, Agrotis segetum (Lepidoptera: Noctuidae Schiff) contains 10:OAc, 12:OAc, Z5‐12:OAc, Z9‐12:OAc, 11–12:OAc, Z5‐14:OAc, Z7‐14:OAc and Z11‐16:OAc. To find out whether any of t
An established MP2RAGE protocol for semi-quantitative structural brain MRI was transferred from one 7T MR scanner to that of another vendor featuring comparable hardware, but opposite polarity. On this system, the scan time could be reduced from 11 to 8 minutes, mainly by elliptical k-space sampling. Three configurations of radio-frequency (RF) transmission were compared (single channel with quadr
The design of the stator insulation system for a traction machine used in electric vehicles is a challenge due to the tight requirements set on compact size, high dynamic stresses and a lack of automotive specific insulation standards. A poorly designed stator insulation can lead to safety issues and stator faults. Approximately, 20-30% of faults in traction machines are stator faults. In order to
Lignin is the most abundant aromatic biopolymer on Earth, and its aromatic structure makes it a promising platform for the production of biobased chemicals and other valuable building blocks. The valorization of lignin into chemicals currently presents a challenge, and its facilitation is key in the development of viable lignocellulosic biorefinery processes. This study presents a conceptual desig
UNLABELLED: The aim of this systemic review and meta-analysis was to examine the differences in caesarean section rates across European regions and at a country level by utilizing the Robson classification system. The study has compared caesarean rates across European regions using the Robson classification to identify the drivers of caesarean section use. This review shows significant variations
The interaction between a low angle grain boundary in front of a crack tip and the emerging plasticity from the tip of a microstructurally short edge crack subjected to fatigue loading has been studied. The modeling rests solely on discrete dislocations, were the geometry is described by dislocation dipole elements in a boundary element approach and the plasticity, restricted to one slip plane, to
This theoretical paper adopts a procedural perspective to identify the challenges associated with the implementation of the full scope of approaches to circular public procurement (CPP). We contend that beyond considering CPP from a substantive standpoint (i.e. the procurement affects outside of the organization), adopting a procedural perspective (i.e. the procurement affects inside an organizati
GTP hydrolysis is a biologically crucial reaction, being involved in regulating almost all cellular processes. As a result, the enzymes that catalyze this reaction are among the most important drug targets. Despite their vital importance and decades of substantial research effort, the fundamental mechanism of enzyme-catalyzed GTP hydrolysis by GTPases remains highly controversial. Specifically, ho
We present the design of the vacuum chamber for the LNLS 2T Hybrid Wiggler. The chamber is a 3m long, 1.2mm thick 316L SS tube, which was mechanically pressed into an elliptical shape from an originally round tube. In order to provide the necessary mechanical tolerances, the rather flexible tube is welded to lateral supports that run the complete length of the chamber. Special care has been given
BACKGROUND: The NextFood Project ( www.nextfood-project.eu) started work in 2018 to identify 'Categories of Skills' that students should be equipped with to address the upcoming global challenges within agrifood and forestry disciplines, and involved concepts such as sustainability, technological adaptation and networking. This study is based on the initial skills and competencies mapping, but tak
Introduction: Rimegepant is an oral small-molecule calcitonin gene-related peptide receptor antagonist approved in several countries for acute treatment of migraine and preventive treatment of episodic migraine in adults. This review summarizes the evidence, published to date, for the use of rimegepant as an acute or preventive treatment of migraine. Areas covered: A brief overview of migraine, th
High-order interactions associated with non-small cell lung cancer (NSCLC) survival may elucidate underlying molecular mechanisms and identify potential therapeutic targets. Our previous work has identified a three-way interaction among pack-year of smoking (the number of packs of cigarettes smoked per day multiplied by the number of years the person has smoked) and two DNA methylation probes (cg0
BACKGROUND AND AIM: Warming temperature promotes bacterial growth while extreme precipitation enhances fecal-oral route of exposures to these pathogens, particularly in resource limited settings, increasing burden of diarrheal diseases. Given climate change related increases in frequency of extreme events, there is a pressing need to develop meaningful early warning system with adequate lead time
Generative AI tools (GenAI) are increasingly used for academic tasks, including qualitative data analysis for the Scholarship of Teaching and Learning (SoTL). In our practice as academic developers, we are frequently asked for advice on whether this use for GenAI is reliable, valid, and ethical. Since this is a new field, we have not been able to answer this confidently based on published literatu
Purpose: To remedy the lack of a measure that jointly assesses the psychological status and impact of migration stressors among forced migrants, we developed and tested the Screening of Refugees Self-Report (ScoRE-SR) Questionnaire.Method: Four institutions with expertise on posttraumatic symptomatology and/or migration stressors developed the ScoRE-SR through an iterative process also involving c
In pursuit of advancing the capabilities of ground testing facilities, a complete road map for broadening operational range of the H3 hypersonic blowdown wind tunnel, operated at the von Karman Institute for Fluid Dynamics (VKI), with the addition of a new Mach 5 contoured nozzle is constructed. The main characteristics of the facility are presented. The supersonic ejector is identified as a criti
