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Introduktion: Flera studier har påpekat att det kan finnas ett samband mellan förändringar i nivån av kvinnligt könshormon och förvärrad tandlossning. Hur östrogen påverkar tandfästet är inte kartlagt. Det finns två östrogenreceptorer (ER), ERα och ERβ och betydelsen av de båda receptorerna är inte kartlagda. Målet med denna avhandling har varit att undersöka uttrycket av ER i bindvävsceller i rotAbstract INTRODUCTION: Several studies have addressed the association between changes in levels of the female sex hormone, estrogen, and changes in the parameters of periodontitis, but the mechanism behind estrogenic effects in the periodontium is poorly understood. There are two subtypes of estrogen receptors (ER), ERalpha and ERbeta. The objectives of the present studies were to map periodontal

It has been previously suggested that leukotriene-induced Ca2+ signalling is mediated through a Rho-dependent process, but neither direct activation of Rho nor a mechanism underlying such signalling has been reported. Accordingly, we used the Rhotekin binding assay to assess RhoA activation in intestinal epithelial cells and observed that RhoA was activated by leukotriene D4 (LTD4). We also found

OBJECTIVE: Periodontal ligament (PDL) cells express oestrogen receptor beta (ERbeta) protein, but cellular functions regulated by ERbeta in these cells have not been identified. In this study we determine if ERbeta is localised to mitochondria and if oestrogen regulates mitochondrial function in human PDL cells obtained from teeth extracted for orthodontic reasons. DESIGN: Subcellular distribution

Announcement postdoc scholarship V 2026/2825 Sida 1 av 4 Department of Experimental Medical Science Linda Eliasson Scholarship coordinator ANNOUNCEMENT Reference number V 2026/2825 Date 25 September 2026 The Department of Experimental Medical Science, Virus Biophysics Group hereby announces a postdoc scholarship Lund University was founded in 1666 and repeatedly ranks among the world’s top 100 uni

https://www.intramed.lu.se/sites/intramed.lu.se/files/2026-09/2026-2825%20Postdoc_Research_Project_BioAFM_Virus_Host_and_Cancer_Cell_Mechanics.pdf - 2026-10-06

Amyloid β peptide (Aβ) is the crucial protein component of extracellular plaques in Alzheimer’s disease. The plaques also contain gangliosides lipids, which are abundant in membranes of neuronal cells and in cell-derived vesicles and exosomes. When present at concentrations above its critical micelle concentration (cmc), gangliosides can occur as mixed micelles. Here, we study the coassembly of th

Transfer of melanin-containing melanosomes from melanocytes to neighboring keratinocytes results in skin pigmentation. To provide a more practical method of visualizing melanosomes in melanocytes as well as in keratinocytes, we attempted to use murine cell lines instead of human primary cells. We generated various fluorescent fusion proteins of tyrosinase, a melanin synthesis enzyme located in the

Dye affinity chromatography is one of the chromatography techniques which uses dye as a ligand for protein purification. In this study, single-layer poly(acrylamide-allyl glycidyl ether) cryogel was prepared, which contains free epoxy groups at sub-zero temperature. The double-layer was prepared inside a primary single-layer cryogel to form a secondary network inside the gel. Cibacron Blue F3GA wa

Poly(d,l-lactide-co-glycolide) (PLG) is the most frequently used biodegradable polymer in the controlled release of an encapsulated drug. The purpose of this work was to explain the surprisingly slow diffusion through this polymer, and locate the major source of mass transport resistance. Diffusion of human growth hormone (hGH) and glucose through PLG films was undetectable (using a diffusion cell

Antibodies to double-stranded (dsDNA) are associated with systemic lupus erythematosus (SLE) and directly involved in human lupus nephritis. Information about their glomerular target antigens is inconsistent, and whether availability of target antigens, antibody specificity or avidity are nephritogenic parameters, is not determined. In this study, we analyzed renal tissue from anti-dsDNA antibody-

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacterial colonization and infection. In the present study, bacterial biofilm was visualized by electron microscopy at the surface of AD skin. Correspondingly, Staphylococcus aureus (S. aureus) isolates from lesion

Cooperative binding is a key feature of metabolic pathways, signaling, and transport processes. It provides tight regulation over a narrow concentration interval of a ligand, thus enabling switching to be triggered by small concentration variations. The data presented in this work reveal strong positive cooperativity of α-synuclein binding to phospholipid membranes. Fluorescence cross-correlation

Lipid nanoparticles (LNPs) have emerged as an efficient platform for mRNA delivery, in which ionisable lipids play a central role in intracellular uptake and endosomal escape. In this study, the influence of different ionisable lipids on cellular uptake, endosomal damages and mRNA release kinetics was investigated to identify promising LNP compositions for effective mRNA delivery. Dose-dependent L

250224 Name of PI Malin Parmar Faculty/Department Faculty of medicine/Experimental medical science (EMV) E-mail malin.parmar@med.lu.se Telephone +46 46 222 06 20 Cost center 314062 Responsible researcher Edoardo Sozzi E-mail to researcher edoardo.sozzi@med.lu.se Project title Fabrication of microfluidic devices for connectoid formation Aim of project (max 1100 characters) The aim of this first exp

https://www.bme.lth.se/sites/bme.lth.se/files/2025-10/12_MalinParmar_250224.pdf - 2026-10-06

Experiments were conducted to investigate the "paired" arbuscules characteristic of Arum-type mycorrhizal colonization in Linum usitatissimum L. The development and senescence of arbuscular structures were followed in a time course study. Roots were freeze-sectioned longitudinally and mycorrhizal structures visualized using nitroblue tetrazolium, a vital stain to indicate metabolically active arbu