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Human antibodies directed towards functionally associated tumor antigens have great potentials as adjuvant treatment in cancer therapy. Here we describe an efficient subtractive approach to select single chain Fv (scFv) antibodies, specifically binding to unknown rapidly internalizing tumor-associated antigens (TAA) on human breast and pancreatic carcinoma cell lines. After re-engineering the scFv
Biological membranes and human interfaces are maintained under non-equilibrium conditions, where they are constantly exposed to different stimuli. The aim of this work is to advance our knowledge of human interfaces and evaluate how they respond to stimuli they naturally encounter, such as fluctuations in external humidity conditions, temperature, or UVB irradiation. In the first part of this thes
Här hittar ni de "Prova på aktiviteter" och workshops som ni har möjlighet att anmäla er till under UniStem-eftermiddagen. Populärvetenskapliga bilder av stamceller Ansvarig: Kristofer Hansson, Ellen Suneson (Institutionen för kulturvetenskaper) Antal studenter: ca 15 Beskrivning: Genom TV, tidningar och internet möter allmänheten de biomedicinska forskarnas framsteg inom dagens stamcellsforskning
https://www.stemcellcenter.lu.se/research-school/program-overview/public-engagement/unistem2015/workshops - 2026-10-05
Senior lecturer Contact details Email: andrea [dot] scotti [at] chem [dot] lu [dot] seOrganisation Physical Chemistry Service point: 1 Research InterestsThe main subject of my research is experimental soft matter, with particular focus on the relationship between microscopic architecture of soft building blocks, e.g. microgels, and the macroscopic response of a soft material, both in three and two
https://www.physchem.lu.se/andrea-scotti - 2026-10-05
Due to their unique optical properties, III-V nanowires are promising candidates for the development of efficient solar cells, LEDs and nanoscaled lasers. The interaction of nanowires with fluorescent molecules is also of interest, as these nanostructures can act as nanoscaled optical fibers. The light emitted by a fluorophore close to a nanowire surface can in fact couple into the supported waveg
https://www.admire.lu.se/links/ - 2026-10-05
WCMM Fellow | Molecular Skeletal Biology Research focus Bone is a complex organ providing structural and mechanical support to our body, but also consisting in our principal hematopoietic centre. The formation of our bones is tightly and timely orchestrated, involving stages of cartilage, vasculature, bone and bone marrow establishment. Bourgine lab aims at compiling human-specific knowledge on ho
https://www.wcmm.lu.se/paul-bourgine - 2026-10-05
Boronate-containing thin polyacrylamide gels (B-Gel), polymer brushes (B-Brush) and chemisorbed organosilane layers (B-COSL) were prepared on the surface of glass slides and studied as substrates for carbohydrate-mediated cell adhesion. B-COSL- and B-Brush-modified glass samples exhibited multiple submicron structures densely and irregularly distributed on the glass surface, as found by scanning e
Pancreatic islet hormones regulate blood glucose homeostasis. Changes in blood glucose induce oscillations of cytosolic calcium in pancreatic islet cells that trigger secretion of three main hormones: insulin (from β-cells), glucagon (α-cells) and somatostatin (δ-cells). β-Cells, which make up the majority of islet cells and are electrically coupled to each other, respond to the glucose stimulus a
This is the first study on freeze-dried foams prepared from glutenin- and gliadin-rich fractions of wheat gluten and blends thereof. It was found that the foam density and stiffness could be controlled by a suitable choice of the glutenin/gliadin ratio. The glutenin-rich samples had the highest foam densities and the density decreased with increasing gliadin content. The compression modulus also d
Ionic microgels are intriguing soft and deformable colloids with an effective pair potential that crosses over from Yukawa-like at large distances to a much softer repulsive interaction at short distances. Here we report the effect of adding an anisotropic dipolar contribution to colloids with such "ultra-soft" interactions. We use an alternating electric field to induce a tunable dipolar contribu
Thermoresponsive microgels find widespread use as colloidal model systems, because their temperature-dependent size allows facile tuning of their volume fraction in situ. However, an interaction potential unifying their behavior across the entire phase diagram is sorely lacking. Here we investigate microgel suspensions in the fluid regime at different volume fractions and temperatures, and in the
The Caenorhabditis elegans (C. elegans) germline is used to study several biologically important processes including stem cell development, apoptosis, and chromosome dynamics. While the germline is an excellent model, the analysis is often two dimensional due to the time and labor required for three-dimensional analysis. Major readouts in such studies are the number/position of nuclei and protein
There is a need to develop innovative cheese processes to meet consumer demands and improve production efficiency. In this study, rennet skimmed milk curds (SMC), and butter were emulsified using a thermo-mechanical process at temperatures between 70 and 90 °C. The composition, rheological properties, and microstructure of the emulsion gels were analysed up to 2 weeks of storage. Confocal laser sc
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 (Gpc-1) is generated in endosomes by an endogenously or ascorbate induced SNO-catalyzed reaction. Processing of the amyloid precursor protein (APP) and APP-like protein 2 (APLP2) by β- and γ-secretases into amyloid beta (Aβ) and Aβ-like peptides also takes place in these compartments. Moreover, anMan-co
