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To compare clonal evolution in tumors arising through different mechanisms, we selected three types of sarcoma—amplicon-driven well-differentiated liposarcoma (WDLS), gene fusion-driven myxoid liposarcoma (MLS), and sarcomas with complex genomes (CXS)—and assessed the dynamics of chromosome and nucleotide level mutations by cytogenetics, SNP array analysis and whole-exome sequencing. Here we show
The present study investigates the significance of potential slip in the bracings of simply supported slender timber members. Three bracing configurations are considered. The first case is that of a timber beam braced at one point at mid-span, the second one braced at two points and the third one braced at three points. Possible slip in the bracing members can for example be due to joint deformati
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing mu
Background: Treatment of patients with knee osteoarthritis is challenging. Unloader braces have been developed with various success. Unloader One® Knee Brace is light, easily-fitted and shown to be effective by the unloading of the affected compartment. The aim of the study was to assess the clinical outcome of the brace vs. a placebo on patients with knee osteoarthritis. Methods: Initially 150 pa
The concept of teamwork has been associated with improved patient safety, more effective care and a better work environment. However, the academic literature on teamwork is pluralistic, and there are reports on discrepancies between theory and practice. Furthermore, healthcare professionals’ direct conceptualizations of teamwork are sometimes missing in the research.In this study, we examine docto
This study analyses the implementation and sustainability of evidence-based community mental health services in the form of publicly financed Individual Placement and Support programs. Critical implementation components and program fidelity were assessed after one year. After two years, program fidelity was assessed once again. After three years, the programs’ sustainability was assessed and semi-
Background. Arterial spin labeling is an MR imaging technique that measures cerebral blood flow (CBF) noninvasively. The aim of the study is to assess the diagnostic performance of arterial spin labeling (ASL) MR imaging for differentiation between high-grade glioma and low-grade glioma. Methods. Cochrane Library, Embase, Medline, and Web of Science Core Collection were searched. Study selection e
The global CO2 emissions in 2010 from fossil energy use grew at the fastest rate since 1969. The year 2010 also witnessed that the global oil production did not match the rapid growth in consumption [1]. These recent data further intensify worldwide concerns about greenhouse gas emissions and energy security for a sustained economic development. For a reduced dependence on oil from fossil reserves
The calls for evidence-based public policy making have increased dramatically in the last decades, and so has the interest in evidence-based sustainability studies. But questions remain about what “evidence” actually means in different contexts and if the concept travels well between different domains of application. Some of the most relevant questions asked by sustainability studies are not, and
The orientation towards grand societal challenges can be seen as a new wave or paradigm for innovation policy. Such policy aims at system-wide transformation and is often referred to as system innovation policy. While insights from transition studies have provided novel and useful rationales for innovation policy targeting system-wide transformation, it remains unclear how to design, implement and
The high negative exploration rate in patients with suspected acute appendicitis is the main compelling reason to improve the accuracy in managing patients with acute abdominal pain. In this article, data from a prospective study on a group of patients undergoing acute appendectomy were used to devise a scoring system for the purpose of differentiating between the patients with an acute appendicit
Today's IT organizations must ensure that IT services are aligned to business needs and actively support ongoing business processes. This means that internal IT service management processes are under constant improvement. However, to be able to know if the IT service provision develops in the right direction, there is a need to perform some kind of self-assessment of IT process maturity. In this p
Public procurement for innovation (PPI) is a powerful, underutilized demand-side innovation policy instrument. How this instrument can contribute to meeting societal challenges, which require goaloriented transformation of socio-technical systems, remains unclear and is explored in this article. This article draws on the transitions and PPI literature to propose transformative processes to which P
A baseflow separation methodology combining the outcomes of the flow–duration curve and the digital filtering algorithms to cope with the restrictions of traditional procedures has been assessed. Using this methodology as well as the monitored and simulated hydro-climatological data, the baseflow annual variations due to climate change and human-induced activities were determined. The outcomes sho
In the present study, the effect of carbon nanotubes (CNTs) either single walled (SWCNT) or multi walled (MWCNT) on sugar oxidation by Corynascus thermophilus cellobiose dehydrogenase (CtCDH) is investigated. The current observed for the direct electron transfer (DET) communication between the enzyme and the electrode is compared to that of the mediated electron transfer (MET) obtained from CtCDH/
Blood biomarkers have emerged as accurate tools for detecting Alzheimer’s disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis. Yet, the logistics surrounding venipuncture for blood collection, although considerably simpler than the acquisition of imaging and CSF, require precise processing and st
Europe’s Beating Cancer Plan is a substantial European Union (EU) investment into cancer prevention and treatment. Integration of genetic services towards personalised cancer prevention and care is a flagship of this plan. Genetic counselling is critical to this integration, facilitating informed patient decision making and improved clinical management. However, growing demands for genetic testing
