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Natural autoantibodies (NAAbs) are immunoglobulins generated in the absence of antigen provocation, with no inherent pathogenic effect, but instead involved in maintaining immune homeostasis. We aimed to evaluate the implication of immunoglobulin G (IgG) antibodies against heat shock protein 90α (HSP90α) in systemic lupus erythematosus (SLE) patients, focusing on how those NAAbs may interfere with

Controlling the surface morphology and chemical interaction is necessary for the development of advanced quantummaterials, particularly in low-dimensional systems. As the research increasingly focuses on miniature and nanoscaletechnologies, a fundamental understanding of localized or interface states becomes essential for successful integrationinto functional devices. This thesis investigates atom

Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was

The study aimed to investigate the unique lipid composition of Mycobacterium bovis BCG and its potential to enhance antimicrobial efficacy of lipid-coated mesoporous silica particles (MSPs). The bacterial lipids (BL) were extracted with petroleum ether and analyzed via LC-MS, revealing a complex mixture of phospholipids, including cardiolipin, phosphatidylcholine, phosphatidylethanolamine, and tri

Additives such as binders and hydrophobic agents are commonly introduced into the fibrous Gas Diffusion Layer (GDL) of proton exchange membrane fuel cells to enhance mechanical strength and facilitate water management. However, the effect of additive/fiber content and surface wettability on water removal, oxygen diffusion, and heat conduction remains insufficiently understood. In this work, we dev

Background: Microscopic colitis (MC) is characterized by non-bloody, watery diarrhea predominantly in elderly women. Known risk factors are smoking, medication with NSAIDs, PPIs or SSRIs, while data on hormonal factors is sparse. The aim of the present study was to investigate whether hormonal factors that disrupt the sex hormonal balance could have an impact on the disease course in MC. Methods:

Background: Evidence is limited on whether alterations in diabetes-related health parameters are detectable before clinical diagnosis in novel diabetes subtypes. We investigated trajectories of diabetes-related health parameters in individuals with recently diagnosed type 2 diabetes (T2D). Methods: Using data from the Stockholm Diabetes Prevention Programme cohort (SDPP) participants (n = 215) wit

Brake particle emissions present significant risks to human health, particularly when they contain metallic fine particles, which can induce oxidative stress, disrupt cellular structures, and cause genetic damage. In this study, an alumina coating was deposited on cast iron discs and a non-asbestos organic (NAO) pad and a low-metallic (LM) pad (as reference) were used as counterparts of the brake

Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposure of PM2.5, PM10 and NO2 on maternal and child proteomic profiles and the risk of daily diary-registered com

Epitaxial shell is vital for enhancing the optoelectronic performance of semiconductor quantum dots (QDs), especially for the wide bandgap blue QDs, yet the shell crystal structure's impact on thermal stability and photophysical behavior remains unexplored. It is reported that the ligand-directed synthesis of ZnS shells with zinc blende (ZB) or wurtzite (WZ) structure on blue WZ CdZnS cores, where

BackgroundWorkplace sexual harassment remains a persistent issue in Sweden. Research about organisational antecedents has been criticised for being limited in scope, possibly overlooking contextual factors relevant for the occurrence of sexual harassment. This study examined two factors capturing aspects of organisational climate, perceived relational justice and authoritarian treatment, and their

Background: Autoantibodies against β-cell components in the pancreatic islets of Langerhans are characteristic of type 1 diabetes (T1D). The genetic and autoimmune determinants of type 1 diabetes (T1D) in Ethiopians are not yet thoroughly characterized, with studies indicating a lower occurrence of autoantibodies related to T1D compared to Caucasians. The study aimed to determine the occurrence of

Policy on greening freight constitutes a recent addition to the discourse on sustainability in the EU. To stimulate economic growth, the EU also plans for freight transport activity to grow significantly over the coming decades. In this paper, drawing on critical discourse analysis and Marxian geographical thought, I show how the argument for implementing sustainable freight is constructed in EU f

REM sleep behavior disorder (RBD), is a prodromal synucleinopathy affecting a subset of Parkinson’s disease (PD) patients and associated with neuropsychiatric symptoms. This study compared the genetic profiles of 13,020 PD patients with probable RBD (PD + RBD) and 5403 without (PD-RBD) using genome-wide association study (GWAS). RBD was assessed by questionnaires or self-reporting. Potential genet

Background: The association between socioeconomic status (SES) and environmental burden is context-dependent. Those with low SES may be more likely to live near major roads and industries where environmental exposures are high but may also be more likely to live further away from city centers. The aim of this study was to investigate the association between SES and environmental burden in Sweden.

Background: Streptococcus pneumoniae is the primary cause of hospitalized community-acquired pneumonia (CAP). Mycoplasma pneumoniae, though typically causing mild respiratory disease, can lead to pneumonia requiring hospitalization in adults. This study compared patients hospitalized with CAP caused by M. pneumoniae or S. pneumoniae aiming at increasing the understanding of when to sample for and

Metastable nonradiative centers (supertraps) are significant energy loss channels in perovskite optoelectronic devices. In their active state, supertraps induce substantial energy loss through nonradiative recombination of free charge carriers. Transitions between active (energy loss) and passive (no energy loss) states result in photoluminescence (PL) blinking on timescales from milliseconds to s