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Objective: Psychosocial stress increases the risk for subsequent episodes of alcohol use disorder (AUD) and drug use disorder (DUD), with most studies assessing stress exposure by questionnaire or interview methods. We developed an environmental risk score (ERS) using multiple classes of stressful life events (SLEs) obtained from national Swedish registries. Method: We assessed, in the entire adul

Gal-3 appears clinically useful for ruling out short-term mortality in patients with acute dyspnea and could have role as a negative prognostic marker in the emergency department.

Background and purpose — Ankle arthrodesis (AA) and total ankle replacement are the 2 main surgical treatment options for advanced ankle arthritis but information is scarce on satisfaction and patient-reported outcome measures (PROMs) after surgery. We aimed to evaluate postoperative satisfaction, changes in PROMs from before to 2 years after AA, and factors associated with the outcome.Methods — T

Background: Ambulatory oxygen therapy can be used to treat exertional hypoxaemia during daily life activities in people with fibrotic interstitial lung disease (ILD). However, evidence for its efficacy is scarce. This trial aimed to compare the effects of ambulatory oxygen with ambulatory air on physical activity in daily life over 6 months in people with fibrotic ILD and isolated exertional hypox

Background: Evidence on the association between systemic glucocorticoid use and colorectal cancer (CRC) risk is limited. This study aimed to determine whether systemic glucocorticoid use is associated with an increased risk of overall CRC (diagnosed at any age) and early-onset CRC (EOCRC; diagnosed before 50 years of age). Methods: A nationwide cohort study (follow-up: 2005–2018) was conducted usi

Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from families of multiple affected members and association of familial risk with metastatic disease and survival. Methods: Familial relative risk of PC was estimated using standardized inc

INTRODUCTION: People with longstanding hip and groin pain (LHGP) are often referred to orthopaedic care. Physical therapist-led interventions are recommended in consensus statements as the first line of treatment, but it is unknown if structured interventions are more effective than usual care. The aim of this trial is to evaluate the effectiveness of a structured physical therapist-led treatment

BACKGROUND AND OBJECTIVE: Although the effects of 5-α-reductase inhibitors (5-ARIs) on prostate-specific antigen (PSA) have been well-studied, the effects on other kallikrein markers have not been firmly established. Accordingly, a statistical model based on blood measurements of four kallikreins-known commercially as the "4Kscore"-cannot be used for men taking 5-ARIs. We investigated how finaster

The growing passion for indoor optical wireless networks reflects their immense capability to deliver consistent high-quality data connectivity across diverse indoor environments. This study examines how polarization can be engineered to enhance near-field beam focusing in optical wireless indoor networks using a modular clustered optical phased array aperture. The aperture follows a ceiling-mount

This paper adds to the growing body of literature on digitally mediated preaching by using actor–network theory (ANT) in conjunction with Amanda Lagerkvist’s work on digital media as theoretical lenses to describe and discuss what we term “the paradox of (im)perfection”. This paradox refers to the tension between an ideal of perfection and an ideal of imperfection (or vulnerability) as experiencedThis paper adds to the growing body of literature on digitally mediated preaching by using actor–network theory (ANT) in conjunction with Amanda Lagerkvist’s work on digital media as theoretical lenses to describe and discuss what we term “the paradox of (im)perfection”. This paradox refers to the tension between an ideal of perfection and an ideal of imperfection (or vulnerability) as experienced

This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, Web of Science, Cumulative Index to Nursing and Allied Health (CINAHL), and The NHS Economic Evaluation Database (NHS EED). Publications were dually screened and

BACKGROUND: Alterations in ribosomal DNA copy number (rDNA-CN) and global DNA methylation have been associated with genomic instability and various diseases. However, their relevance in myocardial infarction (MI) has not been fully investigated.METHODS: We measured rDNA-CN and global DNA methylation in blood samples from MI patients ( n = 100) and healthy controls ( n = 109) using Droplet Digital

Background: Sport-related concussion (SRC) is a common and complex injury in athletic populations. Linear head acceleration (LHA) and rotational head acceleration (RHA) are key biomechanical factors believed to contribute to SRC, each through distinct mechanisms. Evaluating head impact magnitudes across different sports, athlete populations, and measurement methods is essential for advancing SRC i

A commonly used method in remediation projects is to excavate the contaminated soil and treat it in another location or put it in a landfill. The remediation site is then refilled with crushed stones. When the original soil and its initial organisms are removed and replaced with only crushed stones, the environmental properties are changed. This can affect both primary production and the flora and

From a managerial perspective, organizational effectiveness, whether internal or external, is of extreme importance. Therefore, management studies should investigate which phenomena need to be emphasized and safeguarded to utilize organizational effectiveness. Intra-organizational trust and job satisfaction are both defined as phenomena that are of influence on organizational effectiveness. This s