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This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.RESEARCH DESIGN AND METHODS: A group of experts participated in a conference on 14-16 October 2013 cosponsored by the Endocrine Society and the American Diabetes Association. A writing group prepared t
To provide practical guidelines for the cytopathologic diagnosis of malignant mesothelioma.
Over recent years, several tissue engineering techniques are used for bone regeneration. In this study gelatin-hydroxyapatite (Gelatin-HA) cryogel scaffolds were used with/without bone morphogenetic protein-2 (BMP-2) and transforming growth factor beta-1 (TGF-beta 1) to heal critical sized bone defects. Release of growth factors from the cryogels were performed up to 28 days in vitro. Moreover, in
VOR, the versatile optimal resolution chopper spectrometer, is designed to probe dynamic phenomena that are currently inaccessible for inelastic neutron scattering due to flux limitations. VOR is a short instrument by the standards of the European Spallation Source (ESS), 30.2m moderator to sample, and provides instantaneous access to a broad dynamic range, 1-120 meV within each ESS period. The sh
Vi lever idag i vad som enkelt kan liknas vid ett uppkopplat copycat samhälle. Aldrig förut har saker varit så tillgängliga för oss och aldrig förut har saker blivit kopierade i den takt de blir idag. Ordet copy har blivit ersatt av ordet dupe och kopiorna framstår ha kommit in i finrummet. Fast Fashion företag som Zara, Primark och H&M kopierar de stora modehusen såväl som mindre designers. SToday’s society can easily be described as a connected copy-cat society. Never before have things been as accessible as they are today and never before have things been copied at the pace they are being copied today. The word copy have been replaced by the word dupe and dupes as such appears to have become a widely accepted phenomena within the fashion industry. Fast-fashion companies like Zara, P
In order to transform the fossil fuel dependent transport sector the promotion of biofuels has been crucial in the European Union’s transition towards climate neutrality. To ensure the sustainability of biofuels the European Commission published a Delegated Act on March 13th 2019, proposing the gradual phase-out of high emitting biofuels that may cause indirect land use change (ILUC) – one of them
The Light Dark Matter Experiment (LDMX) is a fixed target experiment that will search for dark matter, but is still in the development phase. An important aspect for the experiment is the discrimination of signal and background events. Here this signal and background discrimination is inspected using a machine learning technique called a Boosted Decision Tree (BDT). This is done using Monte Carlo
Idag har de ensamkommande blivit en enskild grupp i asyldebatten. Samtidigt som antalet asylsökande ökade enormt under de senaste åren har debatten om ensamkommande blivit mycket aktuell i medier och regeringen. Den här uppsatsens syfte är att analysera interpellationsdebatten om den nya gymnasielagen ur ett rättssäkerhetsperspektiv och se hur debattörerna ritar upp en bild om ensamkommande barn.
I takt med att den digitala arbetsmiljön växer måste kraven på användbarhet och tillgänglighet tillgodoses. Detta projekt genomfördes i samarbete med Assa Abloy Entrance Systems som är en global leverantör av automatiska entrélösningar. Projektets syfte var att utvärdera och utveckla användarupplevelsen och användbarheten av ett försäljningsverktyg genom att kartlägga och förstå användarna och derAs the digital work environment is growing, the demands of usability and accessibility must be met with increasingly higher standards. This project was performed in collaboration with Assa Abloy Entrance Systems, a global provider of automatic entrances. The project purpose was to evaluate and develop the user experience and usability of a sales tool by mapping and understanding the users and thei
The foreign exchange (FX) market is today the world’s broadest, most active, financial market. One of many technical analysis techniques amongst professional FX traders, trying to narrow down the best entry and exit points in this market, is to utilize pivot points. The ability of this technique has, as far as we know, never been rigorously evaluated. In collaboration with the Malmö-based hedge fu
The emerging green bond market is a novel research area with only a few studies being published in recent years. The increase in interest from issuers, investors, and academia shows the clear need for further investigation of the pricing dynamics affecting the green bond market. This study finds its theoretical foundation in the capital asset pricing model (CAPM), aiming to establish whether inves
Due to changes in land use, as well as impacts from the climate change, our inland waters are now exposed to problems such as eutrophication and brownification. This complicates management to develop clean drinking water, as well as it leads to anoxic bottoms and reduces primary production. This literature review aims to see if wetlands can work as a natural filter to reduce both nutrients (nitrog
This thesis set out to continue the development of a short-wave infrared (SWIR) optical parametric amplifier (OPA). The system is based on a Yb-ber chirped pulse amplification (CPA) laser delivering 400 fs long pulses, centered around 1030 nm, at 200 kHz repetition rate and 40 W average power. The thesis focuses on pulse characterization, through use of frequency-resolved optical gating (FROG), of
Uppsatsen undersöker hur små aktiebolags intressentrelationer kan påverkas av avskaffandet av revisionsplikten.
Vulnerability to climate change and the capacity to adapt to it are the result of intersecting power structures, system dynamics, and social identity markers otherwise known as intersectionality; and thus, differ greatly between contexts. However, despite the stark contextual differences between small and metropolitan cities, and lower and higher income countries, the policy and study of climate c
Denna uppsats behandlar förutsebarheten i påföljdsfrågan för psykiskt störda lagöverträdare. I Sverige har det i flera decennier funnits diskussioner kring de psykiskt störda lagöverträdarnas ansvar. Den nuvarande svenska regleringen är internationellt sett unik, då den inte innehåller ett krav på tillräknelighet. Syftet med uppsatsen är att utreda den svenska regleringen av psykiskt störda lagövThis paper discusses the predictability in sentencing of mentally disordered offenders. For decades there have been discussions in Sweden about the responsibility of mentally disordered offenders. From an international point of view, the current Swedish legislation is unique, due to the fact that it does not contain a requirement for accountability. The purpose of this paper is to investigate th
Denna forskningsrapport inom ramen för ett MSB uppdrag identifierar och kartlägger relevanta datamängder för att bedöma tvärsektoriella sårbarheter för samhällsviktiga verksamheter och kritiska infrastrukturer på nationell svensk nivå. Totalt identifierades 108 datamängder, varav 49 bedöms vara relevanta för analyser på nationell nivå, 54 på regional nivå och 37 på lokal nivå. Identifierad och samThis commissioned research report identifies and maps out relevant data sets to assess cross-sectoral vulnerabilities of vital societal functions and critical infrastructures at a Swedish national level. In total 108 data sets were identified, of which 49 are deemed to be relevant for analyses at the national level, 54 at the regional level and 37 at the local level. Although of high usefulness fo
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
The most prevailing hypothesis regarding mechanisms behind specific language impairment today is the hypothesis of general limitations of processing capacity. Such an hypothesis can hardly be tested by available language assessment tools, especially not by instruments in use for clinical assessment of the lexical-semantic domain in children. Reduced naming speed is by some researchers considered a
This thesis deals with the vital issue of empowerment in development work and development projects, a multimillion dollar enterprise which engages donors,governmental agencies and governments. More specifically the thesis deals with a development intervention in education as social policy in Uruguay, investigated as a case study. The methodological intention is to present the voices of the subject
