Filtyp
As the total cost of renewable electricity falls lower than the price of fossil fuel, not only can electricity be used to replace fossil fuels using batteries in vehicles but it can also be used to produce fuels. This makes it possible to replace fuels in sectors not easily directly electrified. It also provides new ways of balancing the electricity system. When renewable electricity is cheap a lo
Peripheral nerve tumours, most commonly schwannomas and neurofibromas, might present significant challenges by eliciting physical symptoms and emotional distress. We aimed to explore patients’ expectations, perceptions, and experiences regarding their diagnosis and the surgical treatment of a nerve tumour in the upper limb. Fourteen adults (10 women, 4 men; age range 35–85) from two Swedish hand s
Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho
Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address
Background: The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS313 across different European populations which could influence risk estimation has not been performed. Methods: We explored the distribution of PRS313 across European populations using genotype data from 94,072 females without breast cancer
Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN
Background: Collider bias is often considered a potential explanation when the association between obesity and disease diagnosis differs from that with disease outcome, as seen in the “obesity paradox.” For prostate cancer (PCa), in particular localized PCa, an “inverse” obesity paradox has been observed, where body mass index (BMI) is negatively associated with diagnosis (hazard ratio [HR] ~0.9 p
The present work was aimed at developing industrial S. cerevisiae strains with improved tolerance to two types of stressors encountered during the fermentation of lignocellulosic biomass that affect ethanol yield and productivity, namely hydrolysate-derived inhibitors and high temperature, and at understanding the response of yeast and mechanisms of adaptation to such stressors. In one part of the
We consider simple approximations of variances and covariances for order statistics from the standard extreme value distribution. Exact values and simulation results of the variances and covariances for certain sample sizes are used to determine the validity of the suggested approximations.
Spectra of far-infrared conductivity contain useful information on charge transport at nanoscopic length scales. However. decrypting the mechanisms and parameters of charge transport from the measured spectra is a complex task in nanostructured systems in particular, the conductivity is strongly influenced by charge carrier interaction with surfaces or interfaces between constituents of the compos
We present a framework based on object orientation with novel principles for how to store, analyze and integrate electrophysiological data. These principles are: (I) Using a Decorator pattern for storing analysis data in an object model, (II) using a Core Classes data structure for integration through mediation in a service bus architecture, and (III) choosing the single unit as the finest structu
In Swedish higher formal aesthetic education, students from ethnic mi-norities are significantly underrepresented. This also seems to be the case in music education for younger children. Accordingly, the relation-ship between music education and the ethnic diversity of the contem-porary Swedish society, not reflected in the selection of students to the Swedish music and culture schools, is of vita
Background: Ensiling is a common method of preserving energy crops for anaerobic digestion, and many scientific studies report that ensiling increases the methane yield. In this study, the ensiling process and the methane yields before and after ensiling were studied for four crop materials. Results: The changes in wet weight and total solids (TS) during ensiling were small and the loss of energy
BACKGROUND AND PURPOSE: Differences in risk factor profiles between lacunar and other ischemic stroke subtypes may provide evidence for a distinct lacunar arteriopathy, but existing studies have limitations. We overcame these by pooling individual data on 2875 patients with first-ever ischemic stroke from 5 collaborating prospective stroke registers that used similar, unbiased methods to define ri
Genetic and non-genetic factors probably act together to initiate and accelerate development of type 1 diabetes [T1D]. One suggested risk factor contributing to development of T1D is air pollution.
Context: The diagnosis of and reporting parameters for prostate cancer (PCa) have evolved over time, yet they remain key components in predicting clinical outcomes. Objective: Update pathology reporting standards for PCa. Evidence acquisition: A thorough literature review was performed for articles discussing PCa handling, grading, staging, and reporting published as of September 15, 2011. Electro
