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Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos
Auger CVV spectra of simple metals are generally believed to be well described by one-electron-like theories in the bulk which account for matrix elements and, in some cases, also static core-hole screening effects. We present here detailed calculations on Li, Be, Na, Mg, and Al using self-consistent bulk wave functions and proper matrix elements. The resulting spectra differ markedly from experim
Xylosides are a group of compounds that can induce glycosaminoglycan (GAG) chain synthesis independently of a proteoglycan core protein. We have previously shown that the xyloside 2-(6-hydroxynaphthyl)β-D-xylopyranoside has a tumor-selective growth inhibitory effect both in vitro and in vivo, and that the effect in vitro was correlated to a reduction in histone H3 acetylation. In addition, GAG cha
Investigating the role of mitochondrial damage in a Tuberculosis infection Tuberculosis (TB) is a significant health risk that was responsible for 10.4 million infections and 1.8 million deaths in the year 2015 alone. The causative agent for TB is Mycobacterium tuberculosis (Mtb), which is an intra-cellular bacterium that primarily replicates within the white blood cell called the macrophage. To
The aim of this study is to see how big the estimated number of unrecorded cases in Sweden are when it comes to reporting sexual molestation and to see if the court sees the victim as an ideal victim. If so, it is in our interest to investigate if the ideal victim can be associated with the number of unrecorded cases. The cases from the court in Malmö has been coded, placed into charts and analyse
The BRIDGE project is an initiative by the German Federal ex situ Genebank of Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben which aims to make the information stored in the genebank available in a one stop shop fashion for plant breeders and researchers. IPK hosts the biggest genebank in EU-27 and is undertaking a proof-of-concept study based on genotyping-by-sequen
En liten molekyl med en stor uppgift Alla människor ser olika ut, vi har olika hårfärg, är olika långa och har olika hudfärg. Har du någonsin undrat vad det är som gör dig till dig? Svaret är till stor del dina gener. Vi består av celler och varje cell i din kropp har alla dina gener som behövs för att skapa dig. Man kan likna en gen vid ett recept som cellen använder för att veta hur den ska ti
One fifth of the energy consumed by buildings in Sweden is by those built before 1945, many of them constructed from solid masonry walls. Improving their heating energy consumption is a challenge we must face in light of human’s impact on climate change as well as increasing energy costs. Improving thermal performance can be achieved with many insulating materials however the environmental impact
Mot ett säkrare slutförvar för framtida generationer En förutsättning för att det kommande slutförvaret för använt kärnbränsle ska fylla sin uppgift är att alla barriärer som ska förhindra att radioaktivitet läcker ut till omgivningen fungerar under mycket lång tid. En av de viktigaste barriärerna är bentonitleran som ska omge det inkapslade bränslet. Den viktigaste egenskapen hos leran är att denThis report describes a systematic review regarding validations of calculations by measurements of isotopic compositions, or decay heat, on spent nuclear fuel, SNF. 15 relevant or otherwise interesting studies, were found. Two reports were chosen among the found studies and analyzed. One of the studies described validations made with experimental data from measurements of isotopic compositions on
Många system kan representeras som grafer, alltifrån neurala nätverk och transportnätverk till något så vardagligt som våra umgängeskretsar. Om exempelvis Andrea är vän med Jona- than, så kan vi rita ut Andrea och Jonathan som var sin prick på ett paper och låta deras vän- skap representeras av en linje. På samma sätt kan vi enkelt lägga till fler personer (prickar) och rita fler linjer till alla There are many systems which can be represented as graphs, to say the least the networks in which we communicate with each other. Thorough understanding of graph structures enables better predictions of the dynamics in real life networks, such as the spreading of a disease in a community or failure propagation in a system. This thesis investigates information propagation over connected undirected
The space of open source supply chain attacks is ever evolving and growing. There is extensive previous work identifying and collecting open source supply chain attacks, as well as identifying patterns in these attacks and proving that machine learning models may be able to detect these patterns. The aim of this thesis is to develop such a system and study its efficacy in detecting attacks. To ac
Ferroelectric memories pose as a potential candidate as resistive memory devices that could be used for in-memory computing and artificial synapses. One promising type of ferroelectric memory device is the ferroelectric tunnel junction (FTJ). The basic functionality of a FTJ device is based upon the fact that ferroelectric materials display two distinct polarisation states which could be switched
This study aims to examine how NATO-states overtly responds to cyberattacks committed by the believed Russian government sponsored hacker group Fancy Bear. After the end of the Cold War the regulation and acceptance for different kinds of covert actions changed in turn with the change in global power dynamics. The current digital environment develops new ways in which states can spy, gather inform
Cutting carbon emission from road transports worldwide is a key component in limiting global warming, and electrification is one of the most likely automotive technologies to achieve this goal. Therefore, Elonroad is developing an electric road system that will allow its users to charge while driving. This allows greater range and a reduction in battery sizes. This master thesis is therefore aimin
As information technology has grown and evolved, so has the need of securing the information. It is important to evaluate both the security of systems and the methods which are used for the evaluation. One method for finding security vulnerabilities in a system is penetration testing. The goal of this thesis is to evaluate some tools and methods for penetration testing. The methods were examined
Autenticitet ses av vissa forskare som en central del av välbefinnande. Mot bakgrund av detta ville vi fördjupa förståelsen för upplevelsen av autenticitet hos svenska gymnasieungdomar. Inom ramen för projektet “Välbefinnande och självkänsla på gymnasiet” på Lunds universitet genomförde vi semistrukturerade djupintervjuer med sju ungdomar i årskurs tre på gymnasiet om deras erfarenheter av att må Authenticity is viewed by some researchers as a central aspect of well-being. Considering this, we aimed to deepen the understanding of the experience of authenticity among Swedish high-school youths. As part of the research project ”Well-being and self-esteem in high school” at Lund university, we conducted seven semi-structured in-depth interviews with third year high school students about their
This thesis aims to shed light upon the cathar church and its expression of power and hierarchy in their rituals, such as the consolamentum, in conjunction with their theological view of said power and hierarchy. With a hermeneutic theory and a text analysis I read and aim to examine the cathars' own texts in its own context. Through my reading of their theological and ritual texts. I make the
This is a bachelor thesis containing a thematic text analysis of trial documents from the International Criminal Court (ICC) in the case of The Prosecutor v. Bosco Ntaganda. Mr. Ntaganda is up to the present the only one who has been convicted of rape and sexual slavery in the context of war crimes and crimes against humanity by the ICC. The aim of the thesis is to identify and analyze what the IC
