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The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiothe

Human monocytes are a heterogeneous cell population classified into three different subsets: Classical CD14++CD16-, intermediate CD14++CD16+, and non-classical CD14+CD16++ monocytes. These subsets are distinguished by their differential expression of CD14 and CD16, and unique gene expression profile. So far, the variation in inter-cellular gene expression within the monocyte subsets is largely unk

In this study, we partly characterize major histocompatibility complex (MHC) class II B in the blue tit (Cyanistes caeruleus). A total of 22 individuals from three different European locations: Spain, The Netherlands, and Sweden were screened for MHC allelic diversity. The MHC genes were investigated using both PCR-based methods and unamplified genomic DNA with restriction fragment length polymorp

Electron beam optics (particle betatron motion) and trajectory (centroid secular motion) in the FERMI@Elettra free electron laser (FEL) are modeled and experimentally controlled by means of the ELEGANT particle tracking code. This powerful tool, well known to the accelerator community, is here for the first time fully integrated into the Tango-server based high level software of an FEL facility, t

Our study had three objectives: to extend the plasmid-based transformation protocol to a clinical isolate of C. trachomatis belonging to the trachoma biovar, to provide "proof of principle'' that it is possible to "knock out'' selected plasmid genes (retaining a replication competent plasmid) and to investigate the plasticity of the plasmid. A recently developed, plasmid-based transformation proto

The closely related dioecious herbs Silene latifolia and Silene dioica are widespread and predominantly sympatric in Europe. The species are interfertile, but morphologically and ecologically distinct. A study of large-scale patterns of plastid DNA (polymerase chain reaction-restriction fragment length polymorphism) haplotypes in a sample of 198 populations from most of the European ranges of both

It has been suggested that speakers with an L1 with lexical tones may have an advantage when it comes to perceptually discriminating between different tones in another tone language (Kaan, Wayland, Bao & Barkley, 2007). Other studies in L2-learning show that this is not entirely the case (van Dommelen & Husby 2009, So & Best 2010). A model of typological pitch prominence (Schaefer &

Great Spotted and Syrian Woodpeckers (Dendrocopos major and D. syriacus) are known to hybridize in nature; however, the extent of this phenomenon is not known due to difficulties in hybrid detection based on plumage analyses. Here, we tested five markers (one mitochondrial and four nuclear) and a set of six microsatellite loci for the identification of these two Woodpeckers and their hybrids. Sequ

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated wi

Background: Autism spectrum disorders (ASD) are a group of severe childhood neurodevelopmental disorders with still unknown etiology. One of the most frequently reported associations is the presence of recurrent de novo or inherited microdeletions and microduplications on chromosome 16p11.2. The analysis of rare variations of 8 candidate genes among the 27 genes located in this region suggested SE

Det råder i svensk rätt en grundläggande uppfattning om att unga lagöverträdare bör särbehandlas i påföljdssystemet på grund av bland annat deras bristande mognad och relativt stora sanktionskänslighet. Denna uppfattning kommer till uttryck såväl genom reglerna om ungdomsreduktion i 29 kap. 7 § BrB som genom de särskilda ungdomspåföljderna som utgörs av ungdomstjänst, ungdomsvård och sluten ungdomSwedish law embraces the fundamental understanding that juvenile delinquents should be treated differently from adults in the criminal penal system based in part on their undeveloped maturity and particular receptiveness to sanctions. This notion takes its expression in both the rules on youth reduction of sentences under chapter 29 § 7 BrB as well as the specific juvenile sanctions which consists

During reconnaissance field work in the westernmost part of Vestranden, Nord-Trøndelag, Norway, some eclogitic rocks were found (by Leif Johansson and Charlotte Möller). They are of interest, because until now, eclogites have not been found in this northern part of the Western Gneiss Region. It is important to consider these rocks in the evolutionary context of the entire Western Gneiss Region. Th

Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumor stage are loss of heterozygosity in the distal region of chromosome 1p and ampl

The quantitative information in SPECT images is distorted by photon attenuation and contribution of photons scattered in the object. It is, therefore, important to know the distribution of different attenuating tissues in order to be able to perform a proper attenuation correction. A correction method, based on correcting one pixel at a time by using density maps and build-up functions, has been d

Until recently, the testing of ODE/DAE software has been limited to simple comparisons and benchmarking. The process of developing software from a mathematically specified method is complex: it entails constructing control structures and objectives, selecting iterative methods and termination criteria, choosing norms and many more decisions. Most software constructors have taken a heuristic approa

The authors performed a retrospective study of 50 patients with endoscopically diagnosed duodenitis who had undergone double-contrast upper gastrointestinal (GI) examinations. Duodenitis was diagnosed on the original radiographic reports in six of 37 patients (16%) with mild-to-moderate duodenitis, five of 13 patients (38%) with severe duodenitis, and 11 of 50 patients (22%) with all grades of duo

Kommunmedborgare kan agera för att påverka förutsättningarna för den kommunala vardagen och därmed sitt liv. Syftet med denna uppsats är att beskriva de verktyg som är tillgängliga för kommunmedborgare i kommunallagen. Kommunmedborgare fungerar i fem olika aktörsroller; uppdragsgivare, initiativtagare, beredare, brukare och bevakare. Kommunmedborgare ger uppdraget till valda representanter att beLocal Citizens can act to influence the bases of the local everyday life and hence their own life. The objective of this essay is to describe the tools accessible to local citizens in kommunallagen. Local Citizens are in this essay described as five different types of participants. They are assigner, initiator, preparer, user and guarder. Local Citizens gives every fourth year in local elections

Ground construction has to a large extent been dominated by traditional meth-ods during the last 50 years. Although the construction has been changed meanwhile innovations are not accepted. In collaboration with NCC Ltd Region South, I have examined a modern con-struction methodology that has been developed by NCC for future large pro-jects. The method is divided into two central phases. Phase 1 i

A major challenge in evolutionary biology is to understand how complex traits of multiple functions have diversified and codiversified across interacting lineages and geographic ranges. We evaluate intra- and interspecific variation in floral scent, which is a complex trait of documented importance for mutualistic and antagonistic interactions between plants, pollinators, and herbivores. We perfor