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Detection of active tuberculosis (TB) before antiretroviral therapy (ART) initiation is important, but optimal diagnostic methods for use in resource-limited settings are lacking. We assessed the prevalence of TB, evaluated the diagnostic yield of Xpert MTB/RIF in comparison with smear microscopy and culture, and the impact of Xpert results on clinical management in HIV-positive adults eligible fo
Soil degradation is one of the most serious environmental problems in the highlands of Ethiopia. The prevalence of traditional agricultural land use and the absence of appropriate resource management often result in the degradation of natural soil fertility. This has important implications for soil productivity, household food security, and poverty. Given the extreme vulnerability of farmers in th
Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 an
Introduction: Reliable, valid, and easy-to-administer instruments to identify possible “caseness” and to provide proxies for clinical diagnoses are needed in epidemiological research on child and adolescent mental health. The Autism–Tics, ADHD and other Comorbidities (A-TAC) inventory was developed to be used as a comprehensive interview to evaluate neurodevelopmental problems (NDPs), e.g. autism
This licentiate thesis focuses on clustered parametric models for estimation of line spectra, when the spectral content of a signal source is assumed to exhibit some form of grouping. Different from previous parametric approaches, which generally require explicit knowledge of the model orders, this thesis exploits sparse modeling, where the orders are implicitly chosen. For line spectra, the non-l
Fractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain.
The NADPH oxidase 2 (NOX2) complex is a professional producer of reactive oxygen species (ROS) and is mainly expressed in phagocytes. While the activity of the NOX2 complex is essential for immunity against pathogens and protection against autoimmunity, its role in the development of malignant tumors remains unclear. We compared wild type and Ncf1 (m1J) mutated mice, which lack functional NOX2 com
The leadership literature is full of stories of heroic self-sacrifice. Sacrificial leadership behaviour, some scholars conclude, is to be recommended. In this article we follow Keith Grint's conceptualization of leadership as necessarily pertaining to the sacred, butdrawing on Giorgio Agamben's notion of profanationwe highlight the need for organization scholars to profane the sacralizations embed
OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein. Efficacy of specific C5a neutralization was tested using the fusion protein as vaccine in three different arthritis mouse models: collagen induced arthritis (CI
Proliferation, either as the main common denominator in genetic profiles, or in the form of single factors such as Ki67, is recommended for clinical use especially in estrogen receptor-positive (ER) patients. However, due to high costs of genetic profiles and lack of reproducibility for Ki67, studies on other proliferation factors are warranted. The aim of the present study was to evaluate the pro
Human monocytes are a heterogeneous cell population classified into three different subsets: Classical CD14++CD16-, intermediate CD14++CD16+, and non-classical CD14+CD16++ monocytes. These subsets are distinguished by their differential expression of CD14 and CD16, and unique gene expression profile. So far, the variation in inter-cellular gene expression within the monocyte subsets is largely unk
Economical grade changes are considered for a Borealis Borstar polyethylene plant model, incorporating two slurry-phase reactors, one gas-phase reactor and a recycle area with three distillation columns. The model is constructed in the Modelica language and the JModelica.org platform is used for opti- mization. The cost function expresses the economical profit during a grade change and is formulat
In this study the influence of a low-molecular hydrophobic solute on the Bur of a hydrophilic regenerated cellulose membrane and hydrophobic polysulphone membranes with different nominal molecular weight cut-off, NMWCO, was investigated. Octanoic acid was used as a model substance because it is considerably smaller than the NMWCO of all the membranes used in the investigation. Octanoic acid was fo
En skillnad i kvinnor och mäns skattning av sig själva i ett personlighetstest jämfört med hur andra som känner dem ser på dem och om kvinnor och män skiljer sig åt i sättet att välja referenspersoner när de söker arbete. 30 kvinnor och 30 män (18-40 år, M = 22.4, SD = 4.1) genomförde ett Big five-test och jämfördes med två bekantas bedömning. De bekanta var av olika kön varav en fick väljas till
A packaging company is currently evaluating their production and searching for development opportunities to make the production more effective. At the facility for packaging materials there is a production line with two machine-groups consisting of two printers and one laminator. In the present situation the two machine-groups are disconnected from each other by the use of an inventory. The purp
Over the years, Human Computer Interaction has gone through remarkable change, starting from mere on/off switches to modern computer interface which is derived from typewriter. Recently, with the increased processing capabilities of handheld devices, a lot of new interaction methods are emerging, among them is Augmented Reality (AR). In this work, we have presented a study in which AR based intera
S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation end-products (RAGE) interacts with both S100A9 and S100A4. Furthermore, we show that S100A9 and S100A4 interact with RAGE and TLR4; interac
Abstract in UndeterminedThe frequency of eating-related problems in young adolescents, and their stability over a one-year period, was studied by the RiBED-8 (Risk Behaviours related to Eating Disorders, 8 items) in a community sample of 13-15 year old adolescents who took part in a prospective study with a 2-wave longitudinal design. The RiBED-8 was found to have good reliability and construct va
