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During recent years a couple of emergencies have affected the city of Malmo and its inhabitants and forced the city management to initiate emergency responses. These emergencies, as well as other incidents, are situations with a great potential for learning emergency response effectiveness. There are several methods available for evaluating responses to emergencies. However, such methods do not al
Popular Abstract in English Climate migration has become an iconic topic in international climate politics and policy. This work, combining political ecology, critical security studies and post-foundational theories, traces the changes of conflicting discourses across time and space, and assesses the different forms of security they interpellate. While initially attracting attention as a securityThis work seeks to de-naturalise climate-induced migration (CM). Combining political ecology and post-foundational theories, I read CM as a construct that reifies a series of phenomena into an issue to be researched and governed. By assessing the narratives, the knowledge, the logics and imaginaries on which conflicting discourses are built, I analyse the strategies of government they envision. I
The purpose of this thesis is to characterize the health status of the population in early Lund. This is pursued by an osteological analysis of 3.305 individuals fron three time periods: c. 990-1100, c. 1100-1300 and c. 1300-1536. The individuals derives from cemeteries connected to four neighbouring churches, where one is the sucessor of the other (Trinitatis). One cemetery (Kattesund) is by and
Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected fro
Popular Abstract in Swedish Vi lever i en tid då klimatförändringar är en fråga som engagerar, men det krävs en djupare förståelse för hur och varför vårt klimat har förändrats för att möjliggöra realistiska förutsägelser om framtiden. Efterhand som olika metoder för att rekonstruera klimatförändringar har förfinats, och nya dateringsmetoder har utvecklats, så har förståelsen för hur klimatet föräDendrochronological analysis was applied to subfossil remains of Scots pine (Pinus sylvestris L.) buried in South Swedish peat deposits. By cross-dating Swedish bog-pine ring-width (RW) chronologies with corresponding material from North-west Germany, three Swedish RW chronologies were assigned absolute ages and yielded continuous, dated chronologies over the periods 5284-3728 BC and 2668-1108 BC.
Background The Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) blocks the Complement fragment C5a receptor (C5aR) and formylated peptide receptor (FPR) and is thereby a potent inhibitor of neutrophil chemotaxis and activation of inflammatory responses. The majority of the healthy human population has antibodies against CHIPS that have been shown to interfere with its function in vit
Aims: Several studies have shown that self-rated health (SRH ) is associated with drug use. The aim of this study was to investigate the possible interaction between SRH and use of analgesics and hypnotics and its ability to predict disability pension. Methods: In 1974-78, complete birth-year cohorts of middle-aged male residents in Malmö, Sweden, were invited to a health screening, and the cohort
Genetic segregation analysis between NOD and C57BL strains have been used to identify loci associated with autoimmune disease. Only two loci (Cia2 and Cia9) had earlier been found to control development of arthritis, whereas none of the previously identified diabetes loci was of significance for arthritis. We have now made a high-powered analysis of a backcross of NOD genes on to the B10.Q strain
The current development debate emphasizes national ownership of the development agenda as a precondition for sustainable development and aid effectiveness. Vietnam is often held up as a good example of strong ownership. Yet, the ownership concept is not clearly defined or understood due to a lack of empirically rooted evidence and analysis. This study examines the key elements of development owne
Objectives: To describe a nationwide system for postmarketing follow up of new antirheumatic drugs in Sweden, and to analyse safety and effectiveness in an etanercept treated patient cohort. Methods: Etanercept became available in Sweden for prescribing on a named patient basis in 1999. All patients treated were included in a follow up of intensified adverse event reporting and recording of clinic
The recently cloned human chemoattractant receptor-like (CMKRL)1, which is expressed in vivo in CD4-positive immune cells, has structural homology with the two chemokine receptors C-C chemokine receptor (CCR)5 and C-X-C chemokine receptor (CXCR)4, which serve as the major coreceptors necessary for fusion of the HIV-1 envelope with target cells. In view of the structural similarity, CMKRL1 was test
The Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) double mutant N45D/N64D was identified during a previous directed evolution study. This mutant enzyme had a decreased activity towards the natural substrates and decreased feedback inhibition with dTTP, whereas the activity with 3'-modified nucleoside analogs like 3'-azidothymidine (AZT) was nearly unchanged. Here, we identify the mut
BACKGROUND Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that has completed phase II clinical trial in patients with castration resistant prostate cancer, showing promising inhibiting effects on the occurrence of metastasis and delayed disease progression. Its mechanism of action is not fully elucidated, but previous studies show anti-angiogenic effects and strong int
Many Helicobacter spp. were isolated from the stomach, intestinal tract, and liver of different animals and humans. The association between Helicobacter spp. and hepatobiliary diseases, including hepatocellular carcinoma, was thoroughly examined, indicating a potential role of the bacteria in the progression toward cancer. In our work, we screened 97 liver biopsies from patients with chronic liver
Stimulation of CD40 on dendritic cells to expand and activate tumor-specific T cells and generate anticancer immunity is an attractive therapeutic approach. Since CD40 agonists exert their effects upstream of checkpoint inhibitors, including PD-1 or PD-L1 antagonists, they are ideal candidates for combination regimens.
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any
In the human gut, millions of bacteria contribute to the microbiota, whose composition is specific for every individual. Although we are just at the very beginning of understanding the microbiota concept, we already know that the composition of the microbiota has a profound impact on human health. A key factor in determining gut microbiota composition is diet. Preliminary evidence suggests that di
A very large majority of the current product development process models put forward in textbooks present a homogenous structure, what Ulrich & Eppinger [1] call the market-pull model, presented as a generic one, while other possible product development process models are merely seen as variants. This paper focuses on the task clarification and derived activities (mainly the systematic search f
The current form-giving activity in industrial design is characterized by explorations that depend on the individual capability to mentally manipulate a solution space from which to select and express the intended result. Designers often rely on artistic experimentation, aesthetic inspiration, or product specifications. These approaches often lead to satisfactory results, but they could be augment
