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Mouse anticoagulant protein C (461 residues) shares 69% sequence identity with its human ortholog. Interspecies experiments suggest that there is an incompatibility between mouse and human protein C, such that human protein C does not function efficiently in mouse plasma, nor does mouse protein C function efficiently in human plasma. Previously, we described a series of human activated protein C (
Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in t
Background Family history is a strong risk factor for prostate cancer. The aim of this study was to investigate whether increased diagnostic activity is related to the incidence of prostate cancer among brothers of men with prostate cancer. Methods Data were from the nationwide population-based Prostate Cancer Database Sweden (PCBaSe Sweden), which includes data from the National Prostate Cancer R
Context We have previously shown that high levels of atrial natriuretic peptides (ANP) are associated with decreased risk of future diabetes development; however, the mechanism behind this relationship is not fully understood.
Dietary carbohydrates have been implicated in relation to prostate cancer.
This systematic literature review assesses the current state of knowledge on how increased ICT use affects individual time-use patterns and the associated implications for lifestyle climate implications. While the environmental impacts of ICT have been widely debated in terms of direct energy consumption, there has been limited focus on the indirect time-use effects. The review draws on 101 articl
Constitutional monarchy offers Iran a politically stable and culturally resonant alternative to partisan republicanism. Grounded in both empirical research and philosophical tradition, it combines symbolic authority with institutional continuity, enabling national unity without authoritarianism. Monarchs function as neutral anchors above political conflict, often at lower public cost and with grea
This chapter, authored by Oksana Mont, explores the sharing of idle household goods through tool and toy libraries, contrasting them with traditional book libraries funded by local governments. Unlike book libraries, tool and toy libraries face challenges in developing sustainable business models while maintaining community-focused values. Drawing from the "Urban Sharing: Sustainability and Instit
The paper provides an overview and preliminary results from ongoing research with the aim to evolve cross-laminated timber (CLT) into the next generation of Tailored Laminated Timber (TLT). This is done by exploring innovative concepts that optimize the mechanical performance, while simultaneously ensuring adherence to circular economy principles. The current study aims at investigating the potent
INTRODUCTION: We investigated the natural history of the relationship between PSA at age 60 and lifetime risk of prostate cancer death in an unscreened cohort followed for 40 years, the Malmö Preventive Project. We also investigated whether percent free PSA could risk-stratify men with low PSAs.METHODS: The cohort included 1162 men aged 58-62 at blood draw in 1981-82, with 1151 deaths by December
Dating the bottommost section of an ice core is often complicated by strong layer thinning and possible disturbances in the stratigraphy. The radioactive decay of atmospherically produced 36Cl and 10Be can provide age estimates, where traditional methods can no longer be used. In this study, we investigated ice from the bottom of the Skytrain ice core, which was drilled in West Antarctica next to
Current scholarship on urban transformation emphasizes the importance of learning, but the state of the art of research on learning dynamics in urban transformations is still conceptually and empirically fragmented. To address this deficit, we propose a research agenda and related conceptual apparatus that draws upon previous research in urban transformations and cognate fields. The proposed agend
Globalization and commodification trends in football negatively impact the climate in terms of greenhouse gas emissions from leagues and international tournaments. A significant share of these emissions stem from the flying of teams, staff and fans. Using Norway as a case study, we ask what a national football federation is doing and could be doing to reduce its ecological footprint from air trave
BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is a rare cardiac disorder that predispose to supraventricular arrhythmias. Prognosis is usually benign, yet there is an increased lifetime risk of sudden death. While typically sporadic, familial clustering has been reported. This study aimed to assess the risk of WPW, arrhythmias, and mortality among siblings of individuals with WPW.METHODS: This
Soils are essential for life and civilization. They have a long history of political attention, documented at least since Ancient Greece and the Roman Empire. Soil played a key political role in the founding of the USA but gradually lost its clout in the last hundred years. The recent IPCC Special Report on Climate Change and Land may symbolize a return of soils to the political arena. The renewed
This chapter presents two case analyses, one situated in Sweden and the other in Poland, where attempts have been made to intervene in the existing laws regulating access to abortion. The first case involves the lawsuits filed by midwives in Sweden who claimed to have been discriminated against on the grounds of their religion when they had been turned down for work due to their objection to perfo
Building information modeling (BIM) and building energy modeling (BEM) are two key tools to make the transition to net-zero energy buildings (NZEB). However, a recent literature review indicated that the conversion from BIM to BEM is currently dysfunctional, due to limitations regarding competencies, processes, and technology. In this article, a case study is presented to show how the information
This research explores teacher educators' self-reported preparedness to teach students with special educational needs. Teacher educators are concerned with preparing the next generation of teachers who will, in turn, be addressing the needs of students with special educational needs within schools. Being able to address this important task also in their own teaching at the teacher education progra
Between 15 and 27kyrb2k (thousands of years before 2000CE) during the last glacial, Greenland experienced a prolonged cold stadial phase, interrupted by two short-lived warm interstadials. Greenland ice-core calcium data show two periods, preceding the interstadials, of anomalously high atmospheric dust loading, the origin of which is not well understood. At approximately the same time as the Gree
