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During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemota
Eunuchs and members of the transgender community are yet to be recognized as an effective human resource and this diversity in the workforce is still invisible. A tiny portion of the transgender community is employed, and they are tagged as purple collar employees. It is generally claimed that coworkers do not accept members of the transgender community in the workplace and are not willing to work
In the twentieth century, national self-determination came to be regarded as a basic human right. This concept served as the ideological foundation for both the establishment of successor states in Central and Eastern Europe after World War I and the decolonization of the Third World after World War II. All the problems were brought into focus by the new wave of ethnic nationalism that began in Ce
Plasmodium parasites are present in a wide range of host species, some of which tend to be more susceptible than others, potentially as an outcome of evolved tolerance or resistance. Common starlings seem to cope with malaria infection while common crossbills are more susceptible to the same infections. That raises the question if the parasites rely on the same molecular mechanisms regardless of h
Despite being rated as some of the world’s most gender equal countries, Sweden and neighboring Nordic nations show high rates of intimate partner violence against women (IPVAW). As the news media contribute to the shaping of public attitudes, this article pursues a two-step discourse analysis of how IPVAW was represented in seven Swedish newspapers during 2018. Although an individualistic discours
In a UN Security Council meeting (UNSC) on the role of regional organisations and sub-regional arrangements held on 9 March 2015, the UN Secretary-General (UNSG) held that the UN is unable to tackle current security threats on its own. The complexity of these threats requires that it work more closely with regional organisations, including the EU, through improved cooperation and partnerships in s
The fatigue deterioration modeling for welded steel structures subjected to high cycle fatigue is presented in the current document. The aim of this paper is to formulate approaches based on actual research results for the phases fatigue crack initiation, fatigue propagation and fatigue failure. The physical characteristics of the approaches are discussed in combination with the associated uncerta
A reliability-based approach to inspection planning for welded steel structures subjected to high cycle fatigue is presented in the current document. Inspections are an effective means to control the progress of fatigue deterioration and the presented approach allows to determine the minimum required inspection effort so that the considered structure complies with the given risk acceptance criteri
The growing attention to the negative side-effects of our use of plastics has led to numerous calls for changing the current plastics system. However, there is lack of coherent and systematic assessments of how and in what direction the plastics system should change to become more sustainable. This discussion brief explores five potential pathways: Bio-based, Biodegradable, Recycled, Fewer types a
Safety evaluations made in the city Helsingborg indicate a decreased risk of being exposed to crime, but an increased feeling of unsafe. Damage in the form of scribbling (graffiti) is one of several indicators contributing to feeling unsafe. In this paper we investigate whether the use of Internet-of-things technology, where a sensor monitors a walking and cycling tunnel, makes it possible to re
According to EU policy documents, "[s]aving lives of people in distress is a primary goal of EU action in relation to managing the EU external borders."The EU preferred strategy to achieve this objective is to take measures against human smuggling - including the establishment of cooperation with third countries - ostensibly so that migrants are contained and their irregular movement is prevented.
Natural habitats are rapidly declining due to urbanisation, with a concomitant decline in biodiversity in highly urbanised areas. Yet thousands of different species have colonised urban environments. These organisms are exposed to novel urban conditions, which are sometimes beneficial, but most often challenging, such as increased ambient temperature, chemicals, noise and light pollution, dietary
A transition to a more sustainable energy system is called for, and to realise such a transition governments around the world have introduced various research programmes and policy instruments. In this paper, we elaborate on how the transition of the energy system could be reinforced through evaluation of research programmes and policy instruments, focusing on energy efficiency in buildings. We ar
Model programs such as the ‘environmental protection model city’ have become an inherent part of China’s urban environmental governance. The role of these incentive schemes for promoting best practice, however, has been neglected so far. In this study, we show that model city programs raise the bar in terms of environmental standards. What is more, model cities have a positive impact on regional e
Background Identification of lifestyle modifiable metabolic pathways related to cardiometabolic disease risk is essential for improvement of primary prevention in susceptible individuals. It was recently shown that plasma dimethylguanidino valerate (DMGV) levels are associated with incident type 2 diabetes mellitus. Our aims were to investigate whether plasma DMGV is related to risk of future coro
The aim of this study was to explore patients’ experiences of using the Integrated Palliative care Outcome Scale (IPOS) during specialized palliative home care. The study adopted a qualitative approach with an interpretive descriptive design. Interviews were performed with 10 patients, of whom a majority were diagnosed with incurable cancer. Our findings suggest that the use of IPOS as a basis for
Precipitation is often the most important input data in hydrological models when simulating streamflow. The Soil and Water Assessment Tool (SWAT), a widely used hydrological model, only makes use of data from one precipitation gauge station that is nearest to the centroid of each subbasin, which is eventually corrected using the elevation band method. This leads in general to inaccurate representa
This study provides a comprehensive evaluation of eight high spatial resolution gridded precipitation products in Adige Basin located in Italy within 45–47.1°N. The Adige Basin is characterized by a complex topography, and independent ground data are available from a network of 101 rain gauges during 2000–2010. The eight products include the Version 7 TRMM (Tropical Rainfall Measuring Mission) Mul
