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Human papillomavirus type 16 (HPV-16) is a major cause of human cancer. Effective prophylactic vaccines are based on type-specific neutralizing antibodies. A major neutralizing epitope has been defined by the monoclonal antibody H16.V5. To investigate the importance of this epitope for overall immunogenicity of HPV-16, HPV-16 virus-like particles devoid of the H16.V5 epitope were engineered by sit
The empirical part of this study is based on a survey of 600 Swedish households and a number of interviews where questions about residential energy behaviour and possible policy instruments for change were raised. The study provides insight into current behavioural patterns and gives a bottom-up perspective on the realistic perspective potentials for change and ways to achieve them. Residential en
The debate about post-2012 global climate governance has been framed largely by proponents and opponents of the policymaking process established by the United Nations Framework Convention on Climate Change (UNFCCC). In light of the proliferation of institutions governing some aspects of climate change, analysts have asked whether a centralized or a polycentric climate governance architecture will
We developed and validated a high-throughput human papillomavirus (HPV) serology method based on Luminex technology, using pseudovirions (PsVs) of eight mucosal HPV types (HPV 6, 11, 16, 18, 31, 45, 52 and 58) and two cutaneous HPV types (HPV 5 and 38) bound to heparin coated beads. Analysis with neutralising type-specific monoclonal antibodies against included HPV types indicated type-specificity
The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these proc
The fight between a human host and a bacterial pathogen is highly complicated; each party tries to outshine the other in the race for survival. In humans, the innate immune system-in particular the complement system-functions as the first line of defence against invading pathogens. During the course of evolution, however, pathogens, in order to survive and perpetuate within a host, developed multi
BACKGROUND: Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and other spondylarthritides (SpA) impose great impact on the individual in addition to the costs on society, which may be reduced by effective pharmacological treatment. Industry independent health economic studies should complement studies sponsored by industry. OBJECTIVE: To study secular trends in baseline health utilities in pa
An increasing body of evidence suggests that a low-glycaemic-index (GI) diet has a therapeutic as well as a preventive potential in relation to the insulin resistance syndrome. The implementation of a low-GI diet, however, will require an extended list of low-GI foods to be available on the market. The tailoring of low-GI bread products offers a particular challenge due to their generally high GI
Narratological studies have quite frequently focused upon linguistic structures, considered to be paradigmatic cases of narrativity, whereas pictorial signs (such as icons and symbols) or indices have received comparably much less attention. In this paper, however, I intend to outline some basic and regularly occurring narrative aspects of pictures and non-pictorial objects. As a point of depart
A primary purpose of traditional systems analysis is seen as ‘capture’ or ‘elicitation’ of user requirements, in order to produce specifications as a basis for information systems design. Such a view presupposes that user requirements are pre-existing and clear, and that the particular ‘users’ concerned know what they are, and can therefore articulate them. We would argue that none of these assump
Popular Abstract in Swedish Avhandlingen syftar till att bidra till förståelsen av hur det kan komma sig att kristendomen i början av det andra århundradet utvecklas till en icke-judisk religion. Att de judendom och kristendom idag uppfattas som två olika religioner är inte så märkligt. Dock, om man betänker att kristendomen ursprungligen var en del av det första århundradets judendom så är det egThis book attempts to answer the question of how it is possible that Christianity in the beginning of the second century C.E. had developed into a non-Jewish, Gentile religion. Since Christianity was originally one of many Jewish factions within the diversified Judaism of the period, and one that even primarily seems to have directed its attention to the people of Israel, the problem of its separa
Background: Patients with alcohol and other drug use disorders (AOD) frequently have multiple social, physical, and mental health treatment needs, yet have difficulty accessing community services, including drug abuse treatment. One strategy for linking patients with AOD with relevant services is case management, where a single case manager is responsible for linking patients with multiple relevan
Dietary supplements, designed to fortify the antioxidant status of human metabolism, are intended to provide nutritional support against the aging process. The strategy is based on the observation that environmental and metabolic sources of oxidatively generated free radicals damage key macromolecules, such as DNA, that in turn alter physiologic processes, and in turn may contribute to aging and a
Popular Abstract in Swedish Inom många olika fält hyllas dialogen. Det finns en stark och utbredd tro, främst i det västerländska samhället, att lyckas man bara upprätta en dialog kan man planera i samförstånd och lösa problem. Människor talar med varandra för att förstå, hjälpa varandra och för att skapa gemensamma värden och målsättningar. I studiet av samtal upptäcker man emellertid snabbt att In the spring of 1997 a group of parents of deaf and hearing-impaired children and representatives of a special school in the south of Sweden began to hold formally arranged meetings in order to start a “dialogue”. This particular form of collaboration became the focus of this study. The meetings lasted two to three hours and I attended seventeen of them. The transcriptions of those meetings form
